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A kind of photocuring resin and hydrophilic lubricating coating and preparation method

A light-curing resin and lubricating coating technology, applied in coatings, organic chemistry, pharmaceutical formulations, etc., can solve problems affecting biological safety, long curing time, low production efficiency, etc., and achieve excellent biological safety and compatibility properties, shorten curing time, and reduce the coefficient of friction

Active Publication Date: 2017-11-03
清远市美佳乐环保新材股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Domestic patent CN104558658A discloses a method for preparing a hydrophilic lubricating coating on the surface of an interventional catheter. First, the surface of the interventional catheter is modified by grafting acrylic acid, and then coated with polyurethane, aziridine derivatives and polyether-modified polysilicon A primer composed of oxane and a top coat composed of polymethyl vinyl ether-maleic anhydride, acrylic acid, hydroxyethyl acrylate and acrylate derivatives, the hydrophilic lubricating coating prepared by this method has good lubricating properties Good performance and fastness, but the preparation process is complicated, and the grafting time and heat curing time are too long, which makes the production efficiency low
U.S. Patent US2015051556 discloses a method for preparing a hydrophilic coating for medical devices. Under the crosslinking action of acrylic monomers, photosensitive reactive dyes such as acridine orange, rose bengal, and riboflavin are used as photoinitiators. agent to cure water shield polysaccharide mucus onto the surface of the substrate to form a hydrophilic coating. The coating has excellent lubricity, but the use of small molecule dyes as photoinitiators will have problems such as residue, volatilization, migration, etc., and its biological safety in the human body not good enough
[0006] The traditional curing method takes a long time to cure, and the production efficiency is low. However, general photocuring may have problems such as residue, volatilization and migration of small molecule photoinitiators in the human body, which will affect biological safety. Therefore, it is necessary to develop a photopolymerizable Initiator-initiated light curing method not only makes the catheter coating have excellent lubricity and adhesion, but also has good biological safety and can improve production efficiency

Method used

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  • A kind of photocuring resin and hydrophilic lubricating coating and preparation method
  • A kind of photocuring resin and hydrophilic lubricating coating and preparation method
  • A kind of photocuring resin and hydrophilic lubricating coating and preparation method

Examples

Experimental program
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Effect test

Embodiment 1

[0037] 1. Preparation of polymerizable photoinitiators

[0038] Weigh 12.70g (0.05mol) of 4-(2,3-epoxypropoxy)benzophenone into a three-necked flask, raise the temperature to 85°C, and add dropwise 5.10g (0.05mol) of methanophenone while stirring. The mixture of imide, 0.04g p-hydroxyanisole, and 0.06g tetrabutylammonium bromide was dropped within 60 minutes. After the drop was completed, the temperature was raised to 105°C, and the reaction was continued for 2 hours. The product was dissolved with ether, and 2 % sodium hydroxide aqueous solution and deionized water were washed twice, dried over anhydrous magnesium sulfate, filtered, and rotary evaporated by a rotary evaporator to obtain 13.15 g of light yellow viscous liquid.

[0039] 2. Preparation of photocurable resin

[0040] Weigh 11.11g (0.1mol) of vinylpyrrolidone, 0.18g (0.51mmol) of the above-mentioned polymerizable photoinitiator and 0.01g (0.1mmol) of N, N-methylenebisacrylamide and place it in a three-necked flas...

Embodiment 2

[0045] 1. Preparation of polymerizable photoinitiators

[0046] Weigh 15.24g (0.06mol) of 4-(2,3-epoxypropoxy)benzophenone into a three-necked flask, raise the temperature to 85°C, and add 6.78g (0.06mol) of N- The mixture of hydroxymaleimide, 0.05g p-hydroxyanisole, and 0.08g tetrabutylammonium bromide was dropped within 60 minutes. After the drop was completed, the temperature was raised to 105°C, and the reaction was continued for 2 hours, and the product was dissolved with ether. Washed twice with 2% aqueous sodium hydroxide solution and deionized water respectively, dried over anhydrous magnesium sulfate, filtered, and evaporated with a rotary evaporator to obtain 16.33 g of light yellow viscous liquid.

[0047] 2. Preparation of photocurable resin

[0048]Weigh 16.67g (0.15mol) of vinylpyrrolidone, 1.70g (4.64mmol) of the above-mentioned polymerizable photoinitiator and 0.18g (1.2mmol) of N,N-methylenebisacrylamide and place it in a three-necked flask under nitrogen Un...

Embodiment 3

[0053] 1. Preparation of polymerizable photoinitiators

[0054] Weigh 17.78g (0.07mol) of 4-(2,3-epoxypropoxy)benzophenone into a three-necked flask, raise the temperature to 85°C, and add 13.24g (0.07mol) of N- The mixture of phenol-based maleimide, 0.06g p-hydroxyanisole, and 0.09g tetrabutylammonium bromide was dropped within 60 minutes. After the drop was completed, the temperature was raised to 105°C, and the reaction was continued for 2 hours, and the product was dissolved with ether , washed twice with 2% aqueous sodium hydroxide solution and deionized water, dried over anhydrous magnesium sulfate, filtered, and rotary evaporated with a rotary evaporator to obtain 24.22 g of light yellow viscous liquid.

[0055] 2. Preparation of photocurable resin

[0056] Weigh 22.23g (0.2mol) of vinylpyrrolidone, 4.65g (0.01mol) of the above-mentioned polymerizable photoinitiator and 0.54g (5.3mmol) of N-methylolacrylamide and place it in a three-necked flask. Raise the temperature...

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Abstract

The invention discloses a photo-cured resin, a hydrophilic lubricating coating and a preparation method of the photo-cured resin. The photo-cured resin can be prepared by adopting a method of carrying out crosslinking copolymerization on polymerizable diphenyl ketone photo-initiator and a vinyl pyrrolidone monomer under the action of an acrylamide cross-linking agent; a photo-cured hydrophilic lubricating coating can be obtained through compounding the resin. The photo-cured resin is capable of overcoming the disadvantages of residue, volatilization and migration of micro-molecular photo-initiators in coatings, has excellent biological safety and compatibility, and is suitable for the medical field. The hydrophilic lubricating coating has a cross-linking structure, so that the hydrophilic lubricating coating not only has good adhesive force on the surfaces of medical catheters, but also has excellent lubricity when wet, thereby reducing the friction coefficients of the surfaces of the medical catheters, decreasing the harm to the human tissues, and decreasing the adhesion of the macro-molecules in the blood. The hydrophilic lubricating coating is applied to medical catheters in a photo-curing manner; compared with the traditional curing manner, the photo-curing manner has the advantage of greatly shortening the curing time so as to greatly improve the production efficiency.

Description

technical field [0001] The invention relates to a photocurable resin, a hydrophilic lubricating coating based on the photocurable resin, and a method for using the hydrophilic lubricating coating on medical catheters. Background technique [0002] In the medical field, interventional diagnosis and treatment are becoming more and more common. It is a sterile interventional treatment technology guided by imaging equipment such as X-ray angiography, CT, ultrasound, and magnetic resonance. It uses interventional devices such as intravascular contrast catheters. Intravascular catheters such as balloon dilatation catheters, central venous catheters, and trocar peripheral catheters can directly reach the lesion of the human body for minimally invasive treatment. [0003] In clinical application, although this type of medical catheter has a great effect, the catheter itself still has the problem of insufficient surface smoothness. It encounters frictional resistance inside the human...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F2/48C08F226/10C08F234/00C08F222/38C08F220/58C08J7/04C09D139/06C08L75/04C07D207/452C07D207/46A61L29/08A61L29/14
CPCA61L29/085A61L29/14A61L2400/10C07D207/452C07D207/46C08F2/48C08F226/10C08J7/0427C08J2375/04C08J2439/06C09D139/06C08F234/00C08F222/385C08F220/58C08L39/06
Inventor 王小妹封亮廷伍雪芬吴文慧
Owner 清远市美佳乐环保新材股份有限公司