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Vaginal nutrient solution used for improving sperm fertilizing ability and further improving natural fertilization rate and preparation method of vaginal nutrient solution

A technology of fertilization ability and nutrient solution, applied in biochemical equipment and methods, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve rare problems such as increasing the number, improving athletic ability and capacitation, The effect of cheap and easy-to-obtain raw materials

Inactive Publication Date: 2017-11-03
冯浩
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Although various researches and attempts as mentioned above have been made in the prior art to improve the natural conception rate, what the schemes and methods provided in the prior art can do is to change the conception posture or improve the human body There are few studies on how to directly improve the activity of sperm in vitro, and improve the pregnancy rate by promoting sperm movement.

Method used

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  • Vaginal nutrient solution used for improving sperm fertilizing ability and further improving natural fertilization rate and preparation method of vaginal nutrient solution
  • Vaginal nutrient solution used for improving sperm fertilizing ability and further improving natural fertilization rate and preparation method of vaginal nutrient solution
  • Vaginal nutrient solution used for improving sperm fertilizing ability and further improving natural fertilization rate and preparation method of vaginal nutrient solution

Examples

Experimental program
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Effect test

preparation example Construction

[0060] The steps of the preparation method of the vaginal nutrient solution provided by the present invention can be specifically referred to as follows: potassium chloride, sodium dihydrogen phosphate, sodium lactate, 4-hydroxyethylpiperazine ethanesulfonic acid and / or 4-hydroxyethylpiperazine Sodium ethanesulfonate, sodium pyruvate, sorbitol, sodium bicarbonate, tetrasodium EDTA and / or phenol red, magnesium chloride, calcium chloride, fructose, vitamin E, zinc sulfate, in most solvents ( The solvent is a normal temperature solvent, and the temperature is 20-25° C.) to dissolve to obtain the first solution; then, the temperature of the remaining solution is heated (to 30-45° C.) to dissolve the polyvinyl alcohol to obtain the second solution, and then the first solution and the second solution are mixed. The two solutions are mixed to obtain a mixed system, and the volume is fixed;

[0061] Alternatively, heat the used solution to a moderate temperature (30-45°C), and dissolv...

Embodiment 1

[0075] 1. Prepare the solution:

[0076] Weigh the following components in turn with an analytical balance: 0.2386g KCl, 0.0408g NaH 2 PO 4 , 1.4ml sodium lactate, 2.3830g 4-hydroxyethylpiperazineethanesulfonic acid, 0.0220g sodium pyruvate, 2.1864g sorbitol, 0.1680g NaHCO 3 , 0.0380g EDTA tetrasodium salt dihydrate (EDTA 4Na 2H 2 O), 0.1017g MgCl 2 ·6H 2 O, 0.2940gCaCL 2 ·2H 2 O, 0.5000g fructose, 0.3000g vitamin E, 0.1619g ZnSO 4 ·7H 2 O;

[0077] Add 850ml of distilled water at room temperature (about 25°C) into a 1L beaker, place it on a magnetic stirrer, put the rotor into the beaker, start the magnetic stirrer to stir the liquid, add the components weighed above, mix and dissolve, to obtain the first solution;

[0078] Under stirring conditions, gently pour 0.1 g of polyvinyl alcohol (PVA) into 100 ml of distilled water at 30 to 45 °C, and mix thoroughly to obtain a second solution;

[0079] Mix the first solution and the second solution to obtain a mixed syst...

Embodiment 2

[0090] 1. Prepare the solution:

[0091] Weigh the following components in turn with an analytical balance: 0.2370g KCl, 0.0408g NaH 2 PO 4 , 1.868ml sodium lactate, 2.3830g 4-hydroxyethylpiperazine ethanesulfonic acid sodium salt, 0.0220g sodium pyruvate, 2.1864g sorbitol, 0.1680g NaHCO 3 , 0.010g phenol red, 0.102g MgCl 2 ·6H 2 O, 0.2940g CaCl 2 ·2H 2 O, 0.5000g fructose, 0.3000g vitamin E, 0.1619g ZnSO 4 ·7H 2 O, 0.2g povidone-iodine (PVP-I), 0.5000g glucose, 0.1000g ATP, 0.1000g L-carnitine; 0.1000g vitamin C, and 1×10 4 IU Bromelain 10IU / ml;

[0092] Add 950ml of double-distilled water at a temperature of 30 to 45°C into the beaker, then under stirring conditions, add the above raw materials, and stir, mix and dissolve to obtain a mixed system, and set the volume to 1L;

[0093] 2. Osmotic pressure adjustment:

[0094] Add 4.7014g NaCl to the mixed system after constant volume, and adjust the osmotic pressure of the system to 295-310mOsm;

[0095] 3. pH value a...

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Abstract

The invention provides a vaginal nutrient solution used for improving sperm fertilizing ability and further improving a natural fertilization rate and a preparation method of the vaginal nutrient solution. The vaginal nutrient solution disclosed by the invention comprises the following raw material components: fructose, vitamin E, zinc sulfate, sodium chloride, potassium chloride, sodium dihydrogen phosphate, sodium lactate, 4-(2-hydroxyerhyl)piperazine-1-erhaesulfonic acid and / or sodium 4-(2-hydroxyerhyl)piperazine-1-erhaesulfonate, sodium pyruvate, sorbitol, sodium bicarbonate, polyvinyl alcohol, tetrasodium ethylenediamine tetraacetate and / or phenol red, magnesium chloride, calcium chloride and the like. The sperm survival time can be prolonged, the sperm mobility is enhanced, and capacitation of sperms is promoted, so that the quantity and quality of sperms at sites of fertilization are improved, and the pregnancy probability during actual intercourse is increased. The vaginal nutrient solution disclosed by the invention has the advantages of direct action sites, strong action effect and pertinence and the like. Meanwhile, the method disclosed by the invention is simple and convenient to prepare, no large instrument or equipment is needed, and the method is applicable to large-scale industrial production.

Description

technical field [0001] The invention relates to the field of vaginal nutrient solution, in particular, to a vaginal nutrient solution for improving the fertilization ability of sperm and thereby increasing the probability of natural conception and a preparation method thereof. Background technique [0002] In today's society, with the increase of stress and the influence of environmental pollution and other factors, the rate of sexual dysfunction has also increased, which is not only reflected in female infertility, but also caused more and more problems due to the decline of sperm quality. Male infertility. [0003] According to WHO statistics, the global per capita sperm count has dropped from 100 million / ml in 1970 to about 20-40 million / ml. In recent years, the number of patients with oligospermia and asthenospermia in my country has increased significantly, and the sperm count, sperm motility, and sperm survival rate have declined significantly. According to CITIC Xia...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K38/48A61P15/08A61K33/30A61K33/14A61K33/06A61K33/00A61K31/765A61K31/7004A61K31/355A61K31/19A61K31/047A61K31/79A61K31/7076A61K31/205A61K31/375A61K31/495A61K31/198A61K31/39
CPCA61K9/0034A61K31/047A61K31/19A61K31/198A61K31/205A61K31/355A61K31/375A61K31/39A61K31/495A61K31/7004A61K31/7076A61K31/765A61K31/79A61K33/00A61K33/06A61K33/14A61K33/30A61K33/42A61K38/4873C12Y304/22004A61K2300/00
Inventor 李文哲冯浩郝朝亮王向鹏葛龙
Owner 冯浩
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