Method for preparing oil-soluble hydroxyapatite nanometer particles based on nonaqueous system

Abstract

The invention relates to a method for preparing oil-soluble hydroxyapatite nanometer particles based on a nonaqueous system. Soluble calcium salts are dissolved into glycol to obtain a solution A; soluble alkali is dissolved into glycol to obtain a solution B; the solution A, propylene glycol or propanol, fatty acid and the solution B are added into a three-opening flask to be mixed and stirred; asolution C is obtained; soluble phosphate is dissolved into glycol to obtain a solution D; the solution D is dripped into the solution C; stirring is performed to obtain a mixed solution; the temperature of the mixed solution is raised to 80 to 160 DEG C; reaction is performed for 3 to 24 hours; cooling is performed to reach room temperature to obtain reaction liquid; the reaction liquid is subjected to centrifugal separation to obtain precipitates; absolute ethyl alcohol and cyclohexane are used for alternate centrifugal washing to obtain the oil-soluble hydroxyapatite nanometer particles. The method has the advantages that the raw materials are rich in resource and can be easily obtained; the cost is low; a synthesis process is simple; the process repeatability is high; the product quality is stable; the appearance controllability is good; the dispersivity is good; the method can be widely applied to the fields of biomedical materials, coating materials and the like.

Description

technical field [0001] The invention relates to a method for preparing nanomaterials, in particular to a method for preparing oil-soluble hydroxyapatite nanoparticles based on a non-aqueous system. Background technique [0002] Hydroxyapatite is the main inorganic component of human bones and teeth. It has excellent biological activity and biocompatibility, and the crystal has strong ion substitution, so it has great potential in the fields of biological materials, environmental treatment and optical functional materials. Wide range of applications. Flake hydroxyapatite nanoparticles are the main form of hydroxyapatite in bone, and are also the most ideal basic unit for preparing bone repair and bone replacement polymer-based nanocomposites. [0003] At present, the method of synthesizing oil-soluble hydroxyapatite nanoparticles has been extensively studied. CN106063947A discloses a preparation method of monodisperse selenium-doped nano-hydroxyapatite, the method is to add...

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Problems solved by technology

[0005] (1) The flaky hydroxyapatite nanocrystals prepared by general synthesis methods cannot achieve optimal combination in terms of crystallinity, morphology, uniformity, and nanometer size, which is not conducive to giving full play to the advantages of this type of material

[0006] (2) The prepared flaky hydroxyapatite nanoparticles often exist in the oil phase or monomer solution in the form of large aggregates, rather than forming a complete dispersion state, which causes a large number of defects for subsequent material preparation and affects the quality of materials. performance improvement

[0007] (3) Generally, in order to obtain sufficient lipophilicity on the surface of particles, surface modifiers are often added, but the biocompatibility of surface modifiers is often difficult to meet subsequent applications, and the modifiers adsorbed on the surface of particles cannot interact with polymers. Molecules form a strong covalent bond, and the interface bond strength is not ideal

[0008] (4) The common water-alcohol mixed solvent synthesis system either requires high pressure and high temperature conditions, or requires a long synthesis time to complete the crystallization at a relatively low temperature (the time is calculated in days), which have caused great harm to its industrialization and commercialization. big obstacle

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