Titanium-based bone repair material

Abstract

The invention relates to the technical field of medical biomaterial preparation, and in particular to a preparation method of a titanium-based bone repair material. The preparation method comprises the following steps: preparing a nanowire matrix from titanium sheets, preparing a graphene oxide solid from graphite powder and sodium nitrate, preparing a suspension from the graphene oxide solid, adding sodium hydroxide and chloroacetic acid to obtain a carboxylated graphene oxide colloid, doping tris (hydroxymethyl) aminomethane and 1,3-propylenediamine to obtain a graphene nanosheet suspension,and carrying out electrophoretic deposition on the nanowire matrix with the graphene nanosheet suspension and coating liquid as deposition liquid in sequence, so as to obtain the titanium-based bonerepair material. The nanowire matrix can deposit and modify graphene oxide on the surface, thereby improving the biocompatibility and bioactivity of the bone repair material; the titanium-based nanowire matrix is modified by electrophoretic deposition, so as to improve the mechanical strength of the material; calcium and phosphorus elements-containing in casein provide sufficient nutrients for theproliferation of bone cells in the early period; and thus the titanium-based bone repair material has broad application prospects.

Description

technical field [0001] The invention relates to the technical field of preparation of medical biological materials, in particular to a preparation method of a titanium-based bone repair material. Background technique [0002] With the rapid development of the economy, bone defects caused by traffic accidents, industrial injuries, various diseases and trauma are becoming more and more frequent, and bone tissue damage has become a major problem facing human health. At present, autologous bone or allogeneic bone is mainly used for bone repair clinically. However, the source of autologous bone and natural bone is limited. At the same time, there are also problems such as rejection of allogeneic bone, complications in the repair area, and long repair and fusion time. Therefore, There is an urgent need for a new type of artificial bone repair material to solve the above problems. [0003] The ideal bone repair material should first have the following characteristics: [0004] (1...

AI Technical Summary

Problems solved by technology

[0010] The technical problem mainly solved by the present invention is that natural biological materials mainly include collagen, gelatin, fibrin, chitosan, silk protein, decellularized matrix, etc. in current bone repair materials. Natural biological materials are relatively safe and easy to obtain, but The biggest disadvantage is that the degradation is too fast, and the new tissue often cannot achieve a good shape. However, artificial synthetic bone has poor bone induction ability and less bone formation. It provides a preparation method for titanium-based bone repair materials.

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