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Amino acid hydrogel microsphere and preparation method and application thereof

A technology of hydrogel microspheres and amino acids, applied in chemical instruments and methods, pharmaceutical formulations, other chemical processes, etc., can solve limited problems, chronic poisoning heavy metal removal ability and other problems, achieve high selectivity, avoid adverse reactions, The effect of good biocompatibility

Active Publication Date: 2019-01-15
广州市和一医疗科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is that, aiming at the problem of chronic poisoning caused by heavy metal pollution of people's skin in current life and the problem of limited ability to remove heavy metals from the surface of human skin in the prior art, the present invention provides an amino acid with heavy metal binding function Hydrogel microspheres, the amino acid hydrogel microspheres have the ability to bind heavy metals on the skin surface, such as heavy metals such as Pb, Cd and Hg

Method used

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  • Amino acid hydrogel microsphere and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] (1) Preparation of polyaspartic acid hydrogel microspheres containing disulfide bonds

[0039] Disperse 100g of polyaspartic acid in 1000g of water, then add 500g of methanol, 10g of N,N'-bis(acryloyl)cystamine, 10g of glycidyl methacrylate, 10g of cross-linking agent ethylene glycol dishrinkle Glyceryl ether, 0.3g ammonium persulfate, stir well to obtain the water phase; disperse 10g Tween-20 in 500g cyclohexane, stir at room temperature for 1h to obtain the oil phase; add 100ml water phase to 150ml oil phase , stirring to control the particle size, reacting at 90°C for 2 hours, cooling down, and purifying to obtain polyaspartic acid hydrogel microspheres containing disulfide bonds;

[0040] (2) Preparation of amino acid hydrogel microspheres

[0041] Mix 100 g of polyaspartic acid hydrogel microspheres containing disulfide bonds obtained in step (1) with 5000 g of PBS buffer solution containing 100 g of dithiothreitol, adjust the pH to 9, stir for 10 h, and purify to...

Embodiment 2

[0043] (1) Preparation of polyaspartic acid hydrogel microspheres containing disulfide bonds

[0044] Disperse 100g polyaspartic acid in 8000g water, then add 5000g ethanol, 50g N,N'-bis(acryloyl)cystamine, 0.1g glycidyl methacrylate, 50g crosslinking agent diethylene glycol (Diethylene glycol) diglycidyl ether, 0.1g potassium persulfate, stir well to obtain the water phase; disperse 10g Tween-60 in 200g n-heptane, stir at room temperature for 5h to obtain the oil phase; Add phase to 100ml oil phase, stir to control the particle size, react at 20°C for 10h, cool down, purify, and obtain polyaspartic acid hydrogel microspheres containing disulfide bonds;

[0045] (2) Preparation of amino acid hydrogel microspheres

[0046] Mix 100g of disulfide bond-containing polyaspartic acid hydrogel microspheres obtained in step (1) with 3000g of PBS buffer solution containing 50g of vitamin C, adjust the pH to 7.5, stir for 5h, and purify to obtain a particle size of 0.05mm Amino acid hy...

Embodiment 3

[0048] (1) Preparation of polyaspartic acid hydrogel microspheres containing disulfide bonds

[0049] Disperse 100g of polyaspartic acid in 2000g of water, then add 0.1g of acetonitrile, 10g of N,N'-bis(acryloyl)cystamine, 20g of glycidyl methacrylate, and 10g of crosslinking agent trimethylol Propane triglycidyl ether, 1g sodium persulfate, stir well to get water phase; disperse 10g Tween-80 in 1000g pentane, stir at room temperature for 2h to get oil phase; add 100ml water phase to 1000ml oil phase , stir to control the particle size, react at 60°C for 8 hours, cool down, and purify to obtain polyaspartic acid hydrogel microspheres containing disulfide bonds;

[0050] (2) Preparation of amino acid hydrogel microspheres

[0051] Mix 100 g of disulfide bond-containing polyaspartic acid hydrogel microspheres obtained in step (1) with 2000 g of PBS buffer solution containing 100 g of hydrogen peroxide, adjust the pH to 8, stir for 8 hours, and purify to obtain a particle size o...

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Abstract

The invention discloses an amino acid hydrogel microsphere, which is a cross-linking polyaspartic acid hydrogel microsphere containing sulfhydryl groups. The sulfhydryl groups are combined with polyaspartic acid hydrogel microspheres, the synergistic removal effect of the sulfhydryl groups and polyaspartic acid on heavy metals can be fully played, and the amino acid hydrogel microsphere with a heavy metal binding function can be obtained. At the same time, the amino acid hydrogel microsphere with the heavy metal binding function is used in a cosmetic or a drug for bonding toxic heavy metals onskin surface, can effectively and selectively bind and remove the toxic heavy metals on the skin surface, has high selectivity, large adsorption capacityand high adsorption rate, and can avoid adverse reactions caused by oral detoxification drugs.

Description

technical field [0001] The invention relates to an amino acid hydrogel microsphere and its preparation method and application, in particular to a cross-linked polyaspartic acid hydrogel microsphere containing a sulfhydryl functional group, its preparation method and its application in medicine. or cosmetic application. Background technique [0002] With the rapid development of industrialization, heavy metal pollution has become a social concern. Generally speaking, heavy metal pollution refers to the pollution of heavy metal ions such as lead, mercury, cadmium, and arsenic. Due to the random discharge of industrial wastewater, waste gas, and waste residues, as well as the abuse of agricultural pesticides and fertilizers, a large number of toxic heavy metal ions pollute through water, air, soil, and biological chains to animal and plant products and water sources that human beings rely on for survival. cause potential harm. In addition, in daily life, some daily necessiti...

Claims

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Application Information

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IPC IPC(8): B01J20/22B01J20/28B01J20/30A61K8/02A61K8/88A61K9/16A61K31/795A61P39/02A61Q19/00
CPCA61K8/025A61K8/88A61K9/16A61K31/795A61Q19/00A61P39/02B01J20/22B01J20/28019B01J20/28047
Inventor 彭新艳刘云鸿刘云晖
Owner 广州市和一医疗科技有限公司
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