A kind of nitration method of aryl phenols or aryl ether derivatives

A technology of derivatives and aryl ethers, applied in the field of organic synthesis, can solve the problems of many by-products, many by-products of amplified reaction, safety risks, etc., and achieve the effects of being beneficial to industrial production, simplifying production processes, and reducing production costs
CN110590557BActive Publication Date: 2022-07-05SHANGHAI NORMAL UNIVERSITY
9 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
SHANGHAI NORMAL UNIVERSITY
Publication Date
2022-07-05

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention relates to a kind of nitration method of aryl phenols or aryl ether derivatives. In the acetonitrile solution, stirring at room temperature, while monitoring the degree of reaction by TLC dot plate, after the substrate is completely consumed, then remove the solvent with a rotary evaporator, and purify the mixture by silica gel column to obtain the nitroalkene derivative . At the same time, by controlling the nitrate equivalent, the substrate-selective mono-nitration or double-nitration can be realized. Compared with the prior art, the nitration method of the present invention avoids the use of strong acid substances, has mild reaction conditions, high yield, and wide application range of substrates, and the reactivity does not appear to be significantly attenuated after the amplification reaction, still obtains excellent yield, and has obvious advantages. industrial application value.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention relates to the field of organic synthesis, in particular to a nitration method of aryl phenols or aryl ether derivatives. Background technique

[0002] Nitro-substituted aromatic compounds are a kind of very important intermediates, which have a wide range of application values ​​in the fields of medical treatment, pesticides, dyes, and explosives. The traditional nitration reaction uses concentrated sulfuric acid and nitric acid mixed acid as the nitration reagent. This method is mature in technology and low in cost, but has low atomic utilization rate, serious environmental pollution, and many by-products, and the reaction is violent, which has a huge potential safety hazard.

[0003] In recent years, many chemists have been working on the optimization of the nitration of aromatic hydrocarbons. In addition to using nitric acid and concentrated sulfuric acid, trifluoromethanesulfonic acid or acetic anhydride as nitrating reagents (Coon,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More