Blood coagulation promoting and X ray developed embolism agent, preparation method therefor and application of blood coagulation promoting and X ray developed embolism agent
A technology for promoting coagulation and embolic agents, which is applied in the field of procoagulation and X-ray imaging embolic agents and their preparation, can solve the problems of reflux of embolic materials, false embolization effect, instability, etc., so as to avoid reflux and promote thrombosis. , the effect of high sphericity
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[0069] refer to figure 1 , the present embodiment provides a preparation method for promoting blood coagulation and X-ray imaging embolic agent, comprising:
[0070] adjusting the pH value of the sulfate solution to >7 to obtain an alkaline sulfate solution;
[0071] Under stirring condition, described alkaline sulfate solution is added dropwise in the barium salt solution and reacts, obtains the first reactant:
[0072] After adjusting the pH value of the first reactant to 7-8, aging and centrifugation are performed sequentially to obtain barium sulfate nanoparticles;
[0073] Mixing chitosan and polyvinyl alcohol solution protonated under acidic conditions to obtain a PVA / CS solution;
[0074] Mixing and dispersing the barium sulfate nanoparticles and the PVA / CS solution to obtain a mixed phase substance;
[0075] emulsifying the oil phase to obtain emulsified oil phase substances;
[0076] mixing and stirring the mixed phase material and the emulsified oil phase materia...
Embodiment 1
[0113] Prepare 0.5mol / L barium chloride and 0.5mol / L ammonium sulfate respectively. After adjusting the pH of ammonium sulfate to 10 with ammonia water, slowly add dropwise to the barium chloride solution under rapid stirring, barium sulfate nanoparticles are formed immediately and appear White turbid liquid, adjust the pH to 7-8 after the reaction, and then centrifuge and wash to obtain barium sulfate nanoparticles. The prepared nanoparticles were observed by transmission electron microscope (TEM) and field emission scanning electron microscope (FESEM), and the particle size statistical analysis was carried out. attached by figure 1 As shown in (2), the nanoparticles have good dispersibility, and their average particle diameter is 81.70 nm.
Embodiment 2
[0115] Add the PVA powder into the aqueous solution for heat treatment to prepare a 50 mg / mL PVA aqueous solution, and at the same time dissolve the CS powder in 1% acetic acid solution, mix the CS and PVA according to a mass ratio of 5:95, and obtain a PVA / CS mixed solution as Emulsify the cross-linked water phase, Span80 pre-emulsified n-heptane as the oil phase, add barium sulfate nanoparticles according to the mass percentage of 10%, 20% and 30%, stir vigorously and ultrasonically for 30min, then slowly drop into n-heptane After emulsification for 30 min, 3 mL of ether-saturated glutaraldehyde and 2 mL of 1 mol / L hydrochloric acid were added for chemical crosslinking for 5 h, and the reaction temperature was set at 55 °C. After the reaction, wash three times with petroleum ether, ethanol and deionized respectively, then remove residual glycine with 4% glycine, freeze-dry after washed with deionized water, and finally sieve with standard sieves with 100 and 300 μm aperture t...
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