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Fat emulsion, compound amino acid and glucose injection and preparation method thereof

A glucose injection and compound amino acid technology, applied in emulsion delivery, pharmaceutical formula, transportation and packaging, etc., can solve the problems of increasing the economic burden of patients, increasing medical costs, and waste of medical resources, so as to achieve a reasonable proportion and reduce waste , to ensure the effect of stability

Inactive Publication Date: 2020-09-01
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

General hospitals will take the practice of pouring out the remaining liquid medicine directly to prevent many risks that may be caused by overfeeding, including hyperglycemia, changes in liver function, fluid and electrolyte disorders, impaired immune function, increased risk of infection, and poor prognosis. , which not only caused a lot of waste of medical resources, but also increased medical costs and increased the financial burden on patients

Method used

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  • Fat emulsion, compound amino acid and glucose injection and preparation method thereof
  • Fat emulsion, compound amino acid and glucose injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] The total volume of each bag of injection in this embodiment is 900mL, wherein, in each bag of injection, the fat emulsion injection is 159mL, the glucose injection is 553mL, and the compound amino acid injection is 188mL. The fat emulsion, amino acid and The preparation method of glucose injection, comprises the steps:

[0031] Step 1. Bag making

[0032] Take the plastic film for the inner bag, press it on the bag-making hot press and connect the filling port; take the plastic film for the outer bag, press it on the bag-making hot press, and leave one side open.

[0033] Step two, dosing

[0034] Fat emulsion injection, compound amino acid injection and glucose injection were prepared on different preparation equipment.

[0035] (1) Preparation of fat emulsion injection

[0036] Take 31.8 grams of purified soybean oil, 1.91 grams of refined lecithin, 3.50 grams of anhydrous glycerin, an appropriate amount of sodium hydroxide, and 119.25 grams of water for injection...

Embodiment 2

[0052] Step two, dosing

[0053] (2) The compound amino acid injection adopts the following formula: get the following raw materials, L-alanine 3.61g, L-arginine 2.55g, L-aspartic acid 0.77g, L-glutamic acid 1.26g, Glycine 1.78g, L-Histidine 1.53g, L-Isoleucine 1.26g, L-Leucine 1.78g, L-Lysine Hydrochloride 2.55g, L-Methionine 1.26g, L-Benzene Alanine 1.78g, L-proline 1.53g, L-serine 1.02g, L-threonine 1.26g, L-tryptophan 0.43g, L-tyrosine 0.05g, L-valine 1.65 g, calcium chloride dihydrate 0.22g, sodium glycerophosphate anhydrous 1.14g, magnesium sulfate heptahydrate 0.74g, potassium chloride 1.35g, sodium acetate trihydrate 1.84g, an appropriate amount of glacial acetic acid, add the above raw materials Prepare 188mL injection solution in water for injection at 80°C, stir until dissolved under nitrogen protection, and the dissolved oxygen concentration in the solution shall not be higher than 1ppm.

[0054] All the other steps, formula are identical with embodiment one.

Embodiment 3

[0056] Step two, dosing

[0057] (2) The compound amino acid injection adopts the following formula: get the following raw materials, L-alanine 3.01g, L-arginine 2.12g, L-aspartic acid 0.64g, L-glutamic acid 1.05g, Glycine 1.49g, L-Histidine 1.28g, L-Isoleucine 1.05g, L-Leucine 1.49g, L-Lysine Hydrochloride 2.12g, L-Methionine 1.05g, L-Benzene Alanine 1.49g, L-proline 1.28g, L-serine 0.85g, L-threonine 1.05g, L-tryptophan 0.36g, L-tyrosine 0.04g, L-valine 1.37 g, calcium chloride dihydrate 0.18g, sodium glycerophosphate anhydrous 0.95g, magnesium sulfate heptahydrate 0.62g, potassium chloride 1.12g, sodium acetate trihydrate 1.54g, appropriate amount of glacial acetic acid. Add the above-mentioned raw materials into 80°C water for injection that has been deoxygenated in advance to make 188mL injection, and stir until dissolved under the protection of nitrogen. The dissolved oxygen concentration in the liquid should not be higher than 1ppm.

[0058] All the other steps, formu...

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Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a fat emulsion, a compound amino acid and a glucose injection and a preparation method thereof.Three chambers separated by diaphragms are respectively used for containing a fat emulsion injection, a compound amino acid injection and a glucose injection; when in use, three injections can be uniformly mixed and intravenously injected to a human body only by sequentially and forcibly extruding each chamber or tearing the isolation strips between the chambers, and the mixing operation can be carried out under any environmental conditions, so that serious adverse reactions such as transfusion heat source reaction, blood infection and septicemia caused by microbial contamination in the traditional mixing operation are greatly reduced. The total volume of the injection is small, the injection is suitable for providing full parenteral nutrition for patients with extremely low weight and providing supplementary parenteral nutrition for patients with general weight, the formula of the compound amino acid injection is optimized, and the ratio of various amino acids is more reasonable.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a fat emulsion, a compound amino acid and glucose injection and a preparation method thereof. Background technique [0002] Fat, protein and sugar are the three types of basic nutrients that the human body needs the most. When the human gastrointestinal tract is insufficient or cannot absorb enough of the above nutrients, it is provided by intravenous injection of fat emulsion injection, compound amino acid injection and glucose injection, which is called parenteral nutrition. From the perspective of nutrient metabolism mechanism, the utilization of these three nutrients is interdependent. Physiologically speaking, the human body ingests fat, protein and sugar at the same time when ingesting food. Fat emulsion, amino acid and glucose are most in line with the physiological and metabolic needs of the human body, especially when parenteral nutrition...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K9/107A61K31/19A61K31/198A61K31/401A61K31/405A61K31/4172A61K31/7004A61K33/06A61K33/14A61K36/48A61K47/10A61P3/02A61J1/10A61J1/20
CPCA61J1/10A61J1/2096A61K9/0019A61K9/08A61K9/107A61K31/19A61K31/198A61K31/401A61K31/405A61K31/4172A61K31/7004A61K33/06A61K33/14A61K36/48A61K47/10A61P3/02A61K2300/00
Inventor 马志峰李斌刘绿洲于晓蓉
Owner 费森尤斯卡比华瑞制药有限公司
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