3D printed magnetic biological ceramic scaffold and preparation method thereof

A bioceramic and 3D printing technology, applied in the direction of additive processing, can solve the problems of lack of magnetism and controllable pore structure, lack of osteogenesis ability and therapeutic function, etc., achieve good biocompatibility and magnetic properties, improve Cracking problem, the effect of reducing internal stress

Pending Publication Date: 2020-11-27
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the existing bioceramic scaffold materials lack magnetism and controllable pore structure, and thus lack efficient osteogenesis and therapeutic functions.

Method used

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  • 3D printed magnetic biological ceramic scaffold and preparation method thereof
  • 3D printed magnetic biological ceramic scaffold and preparation method thereof
  • 3D printed magnetic biological ceramic scaffold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A 3D printing magnetic bioceramic support, its preparation method comprises the following steps:

[0031] 1) Mix 60g of β-tricalcium phosphate (β-TCP) powder, 6g of iron tetroxide (Fe 3 o 4 ) magnetic nanopowder, concentration is 36g sodium alginate gel (20wt%) and concentration is 8g pluronic gel (10wt%), mix, and add in the high-energy planetary ball mill, ball mill 6h, be suitable for free extrusion Formed printing ink;

[0032] 2) Using 3D printing technology, put the obtained printing ink into the printing cylinder, select the three-dimensional support model, start the printing process to extrude the ink layer by layer to form the magnetic support blank; then soak and dry in the liquid desiccant diethylene glycol for 24 hours;

[0033] 3) Place the dried body in a degreasing furnace at a rate of 1°C / min to 500°C / min and keep it warm for 10 hours, cool to room temperature, then place it in a tube furnace, and heat it at a temperature of 5°C under a flowing nitroge...

Embodiment 2

[0037] A 3D printing magnetic bioceramic support, its preparation method comprises the following steps:

[0038] 1) Mix 60g of calcium silicate (CS) powder, 6g of ferric oxide (Fe 3 o 4 ) magnetic nanopowder, 28g sodium alginate gel (20wt%) and 16g pluronic gel (10wt%), mixed, and added in a high-energy planetary ball mill, ball milled for 6h, to obtain a printing ink suitable for free extrusion ;

[0039] 2) Using 3D printing technology, put the obtained printing ink into the printing cylinder, select the three-dimensional support model, start the printing process to extrude the ink layer by layer to form a magnetic support blank; then soak and dry in triethylene glycol for 24 hours;

[0040] 3) Put the dried green body in the degreasing furnace and raise the temperature at a rate of 1°C / min to 400°C / min for 20 hours in a tube furnace, cool to room temperature, and then place it in a tube furnace, in a flowing nitrogen atmosphere The temperature was raised to 1150°C / min at...

Embodiment 3

[0042] A 3D printing magnetic bioceramic support, its preparation method comprises the following steps:

[0043] 1) Mix 60g of β-tricalcium phosphate (β-TCP) powder, 6g of manganese zinc ferrite (Mn x Zn 1-x Fe 2 o 4 ) magnetic nanopowder, 30g xanthan gum (20wt%) and 14g pluronic gel (10wt%), mixed, and added in a high-energy planetary ball mill, ball milled for 6h, to obtain a printing ink suitable for free extrusion molding;

[0044] 2) Using 3D printing technology, put the obtained printing ink into the printing cylinder, select the three-dimensional support model, start the printing process to extrude the ink layer by layer to form the magnetic support body; then place it in diethylene glycol dimethyl ether to dry for 48 hours;

[0045] 3) Place the dried green body in a degreasing furnace at a rate of 2°C / min to 450°C / min and keep warm for 15 hours in a tube furnace, cool to room temperature, and then place it in a tube furnace, in a flowing nitrogen atmosphere The te...

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Abstract

The invention discloses a 3D printed magnetic biological ceramic scaffold which is prepared by taking biological ceramic powder, magnetic nano powder and a printing aid as main raw materials and sequentially carrying out 3D printing and degreasing sintering according to a three-dimensional scaffold model. According to the invention, a 3D printing technology is adopted, a magnetic nano material isfurther introduced into a biological ceramic material system by combining a liquid drying method and a two-step sintering method, so that the3D printed magnetic biological ceramic scaffold is endowedwith a magnetic effect which is not possessed by a traditional biological ceramic scaffold, the shape control and on-demand customization of the biological ceramic scaffold can be realized, and the biological ceramic scaffold is expected to be used for treating bone tumors and repairing bone defects; and the related preparation method is simple, wide in material source and suitable for popularization and application.

Description

technical field [0001] The invention belongs to the technical field of additive manufacturing of medical materials, and in particular relates to a magnetic bioceramic support and a preparation method thereof. Background technique [0002] Tissue engineering scaffold material is a platform for simulating the function of extracellular matrix, providing cell adhesion and proliferation, and is expected to completely repair the bone defect of the patient. Bioceramic materials are widely used as scaffold materials for bone tissue engineering because of their similar mineral composition to human bone tissue, good biocompatibility, osteoconductivity, and osteoinductivity. [0003] Under the action of an external magnetic field, magnetic materials can promote the proliferation and differentiation of osteoblast-related cells, thereby promoting bone regeneration. In addition, magnetic materials can also kill tumor cells through the magnetocaloric effect, and avoid residual tumor cells...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/22C04B35/638C04B35/64B33Y70/10B33Y10/00
CPCC04B35/447C04B35/22C04B35/638C04B35/64B33Y70/10B33Y10/00C04B2235/36C04B2235/3272C04B2235/6562C04B2235/6586
Inventor 戴红莲黄孝龙胡亚凤庄彭真韩颖超赵政
Owner WUHAN UNIV OF TECH
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