Pharmaceutical preparation for treating intractable epilepsy

A technology for refractory epilepsy and pharmaceutical preparations, applied in the field of medicine, can solve the problems of inability to complete the consistency of absorption and metabolism time, inability to exert synergistic effects, increasing uncertainty in clinical safety, etc., to achieve nutrition and restoration of clinical manifestations. Effect

Inactive Publication Date: 2021-06-25
黑龙江汉普康制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the application of cannabis active substances in the above-mentioned patents is the combined application of one or two monomeric compounds with certain pharmacological effects isolated and extracted from cannabis, or the active monomers have a clear Drugs with pharmacological therapeutic effects are used in combination, and the chemical structures of the active monomers used in combination are quite different, and they belong to different subtype structures in phytocannabinoids. For example, hypotetrahydrocannabinol belongs to the Δ9-THC structure , cannabidiol belongs to th...

Method used

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  • Pharmaceutical preparation for treating intractable epilepsy
  • Pharmaceutical preparation for treating intractable epilepsy

Examples

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Effect test

Embodiment 1

[0053] A pharmaceutical preparation for the treatment of refractory epilepsy, including 10% of cannabis extract, 5% of Gastrodia elata extract, 0.8% of borneol, 7% of succinylated protein, 20% of sesame oil, and 14% of olive oil in weight percentage %, ethanol 10%, polyethylene glycol 17%, deionized water 16.2%;

[0054] Prepared by the following preparation method, comprising the following steps:

[0055] Step S1, preparing succinylated protein;

[0056] Step S2, taking the formula amount of sesame oil, olive oil, ethanol and polyethylene glycol and mixing evenly, adding the formula amount of cannabis extract, Gastrodia elata extract, succinylated protein and borneol under magnetic stirring conditions to obtain a mixed solution;

[0057] Step S3, adding a formulated amount of deionized water to the mixed solution, performing high-shear treatment to obtain a homogeneous mixed solution;

[0058] In step S4, homogenize the prepared homogeneous mixed solution through a high-pre...

Embodiment 2

[0064] A pharmaceutical preparation for the treatment of intractable epilepsy, including 10% of cannabis extract, 6% of Gastrodia elata extract, 1% of borneol, 13% of succinylated protein, 14% of sesame oil, and 15% of soybean oil in weight percentage %, propylene glycol 14%, glyceride 20%, deionized water 7%;

[0065] Prepared by the following preparation method, comprising the following steps:

[0066] Step S1, preparing succinylated protein;

[0067] Step S2, taking the formula amount of sesame oil, soybean oil, propylene glycol and glyceride and mixing evenly, adding the formula amount of cannabis extract, Gastrodia elata extract, succinylated protein and borneol under magnetic stirring conditions to obtain a mixed solution;

[0068] Step S3, adding a formulated amount of deionized water to the mixed solution, performing high-shear treatment to obtain a homogeneous mixed solution;

[0069] In step S4, homogenize the prepared homogeneous mixed solution through a high-pressu...

Embodiment 3

[0075] A pharmaceutical preparation for treating refractory epilepsy, comprising 5% cannabis extract, 1% Gastrodia elata extract, 0.3% borneol, 4% succinylated protein, 2% castor oil, and coconut oil by weight percentage 2%, corn oil 2%, cottonseed oil 2%, evening primrose oil 2%, cod liver oil 2%, linseed oil 2%, mineral oil 2%, olive oil 2%, peanut oil 2%, soybean oil 2%, Sesame Oil 1%, Pine Nut Oil 1%, Wheat Germ Oil 1%, Squalene 1%, Methyl Caprate 1%, Oleic Acid 1%, Ethyl Oleate 1%, Brucea Brucea Oil 1%, Diethylene Glycol Monoethyl ether 2%, lecithin 2%, deionized water 55.7%;

[0076] Prepared by the following preparation method, comprising the following steps:

[0077] Step S1, preparing succinylated protein;

[0078] Step S2, taking the formula amount of castor oil, coconut oil, corn oil, cottonseed oil, evening primrose oil, cod liver oil, linseed oil, mineral oil, olive oil, peanut oil, soybean oil, sesame oil, pine nut oil, wheat germ oil, Squalene, methyl caprate...

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Abstract

The invention discloses a pharmaceutical preparation for treating intractable epilepsy, the preparation comprises a cannabis sativa extract, a gastrodia elata extract, succinylated protein, borneol and an auxiliary agent, the active ingredient of the cannabis sativa extract is a compound with an alkyl resorcinol structure, and the active ingredient of the gastrodia elata extract is a compound with an alkyl resorcinol structure. As an extraction substance which is extracted from a cannabis sativa plant and has the same biological activity, the pharmaceutical preparation has a great synergistic effect on playing a pharmacological effect on refractory epilepsy, and the pharmacological activity of the pharmaceutical preparation is effectively improved; the gastrodia elata extract can provide effective nutrition and repair nerves in the brain, and the borneol can be used as a channel guiding drug to enhance absorption of other drugs in a blood brain barrier and effectively relieve convulsion, spasm, unconsciousness, wandering and other clinical characteristics accompanied by epilepsy disease attack, the succinylated protein in the preparation can prevent the drug from being damaged in an acid environment, and the nano-emulsion preparation prepared by adding the succinylated protein can effectively improve the bioavailability and stability of the drug.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a drug preparation for treating refractory epilepsy. Background technique [0002] Epilepsy is one of the common chronic brain dysfunction diseases that seriously endanger human health. Studies have confirmed that temporary central nervous system dysfunction caused by abnormal discharge of brain neurons is the main cause of epilepsy. It is usually a syndrome characterized by stereotyped central nervous system dysfunction. The seizures of most epileptic patients can be controlled by drug treatment, but some patients respond poorly to antiepileptic drug treatment and their seizures are difficult to control, so they are called intractable. Intractable epilepsy is also called intractable epilepsy, and the treatment of intractable epilepsy is also known as the difficulty in the treatment of epilepsy. [0003] As a chemically complex plant, cannabis itself contains many natural chemi...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/107A61K47/42A61P25/08A61K31/045
CPCA61K36/60A61K36/8988A61K31/045A61K9/1075A61K47/42A61P25/08A61K2300/00
Inventor 王楠
Owner 黑龙江汉普康制药有限公司
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