Calcium sulfate reinforced in-situ curing pore-forming tissue engineering polyester composite scaffold material as well as preparation method and application thereof

A technology of polyester composite materials and polyester materials, applied in the field of bone repair materials, can solve problems such as excessive particle size and inconformity, and achieve the effect of promoting bone repair and improving biological activity

Pending Publication Date: 2022-05-06
FOSHAN HOSPITAL OF TCM +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the diameter of the flaky α-calcium sulfate hemihydrate crystals is 35-42 μm, which is too large and does not meet the requirements of medical implant bone repair materials.

Method used

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  • Calcium sulfate reinforced in-situ curing pore-forming tissue engineering polyester composite scaffold material as well as preparation method and application thereof
  • Calcium sulfate reinforced in-situ curing pore-forming tissue engineering polyester composite scaffold material as well as preparation method and application thereof
  • Calcium sulfate reinforced in-situ curing pore-forming tissue engineering polyester composite scaffold material as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0072] The invention provides a kind of preparation method of calcium sulfate hemihydrate material, comprises the following steps:

[0073] a) After mixing calcium chloride, amino acid and water, a mixed solution is obtained;

[0074]b) After mixing the mixed solution obtained in the above steps, the Ca salt solution and the S salt solution again, the reaction is carried out to obtain a calcium sulfate hemihydrate material having a needle-like crystal structure.

[0075] In the present invention, calcium chloride, amino acid and water are firstly mixed to obtain a mixed liquid.

[0076] In the present invention, the content of calcium chloride in the mixed solution is preferably 0.001-5 mol / L, more preferably 0.01-4 mol / L, more preferably 0.1-3 mol / L, more preferably 1-2 mol / L.

[0077] In the present invention, the mass content of the amino acid in the mixed liquid is preferably 0.01-5%, more preferably 0.1-4%, more preferably 1-3%.

[0078] The present invention mixes the ...

Embodiment 1

[0127] The present embodiment prepares amino acid modified calcium sulfate whisker:

[0128] Prepare 2 parts of 100 mL of CaCl 2 solution, where CaCl 2 The content is 3.5Mol / L, the content of aspartic acid is 2mg / mL, weigh 0.1mol Ca(NO 3 ) 2 4H 2 O and 0.1mol(NH 4 ) 2 SO 4 Add Ca salt solution and S salt solution to the above solutions respectively, then mix the above Ca salt solution and S salt solution, react at 105°C for 4 hours, filter with suction, wash the filter cake with hot water for 4 times, and soak the filter cake with absolute ethanol 3min to terminate the reaction, after suction filtration of absolute ethanol, the filter cake is placed in an 80°C blast drying oven to dry, and the product obtained is the calcium sulfate whisker (Arg 2 -CSH).

Embodiment 2

[0133] Preparation of amino acid modified calcium sulfate whisker reinforced polyester matrix composite scaffold:

[0134] Weigh 2.25 g of the obtained Arg-CSH and add it into 10 mL of N-methylpyrrolidone (NMP), and ultrasonically disperse for 2 hours until the dispersion is uniform. Weigh 1.5g PLGA into the above solution, stir overnight until the PLGA dissolves evenly to obtain a composite material slurry, pour the mixed solution into a self-made cylindrical polytetrafluoroethylene mold, and place it in a -80°C refrigerator for 1 hour. The slurry is solid, then quickly put it into deionized water for replacement, and change the water every 4 hours. After the solvent replacement is complete (4 days), a scaffold composite material Arg-CSH / PLGA with an Arg-CSH content of 60% is obtained for subsequent experiments. detection and characterization.

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Abstract

The invention provides a calcium sulfate hemihydrate material. The calcium sulfate hemihydrate material comprises alpha-calcium sulfate hemihydrate whiskers, the alpha-calcium sulfate hemihydrate crystal whisker has a needle-shaped crystal structure. The alpha-calcium sulfate hemihydrate whisker reinforced degradable polyester composite scaffold is prepared by adopting the alpha-calcium sulfate hemihydrate whisker regulated and controlled by amino acid and adopting a phase conversion method, calcium sulfate is cured in the phase conversion process, and the mechanical property of the scaffold is improved; after the material is implanted, calcium sulfate is degraded to release calcium ions to promote bone tissue repair; meanwhile, calcium sulfate is degraded for in-situ pore forming, cell and tissue ingrowth is promoted, and the osseointegration performance is enhanced; the polyester material matrix delays the degradation rate of calcium sulfate, and the bone repair implant material with proper mechanical properties and the degradation rate matched with the new osteogenesis rate can be obtained by adjusting the ratio of the components. Medical instruments, such as bone grafting materials, injectable bone cement, bone tissue engineering scaffolds and the like, prepared from the novel material are expected to have wide application value.

Description

technical field [0001] The invention belongs to the technical field of bone repair materials, and relates to a calcium sulfate hemihydrate material and a preparation method thereof, a polyester composite material and a preparation method and application thereof, in particular to a calcium sulfate hemihydrate material and a preparation method thereof, a sulfuric acid Calcium-enhanced in-situ solidified tissue engineering polyester composite scaffold material and its preparation method and application. Background technique [0002] With the sharp increase of trauma, tumors, deformities and aging in today's society, the demand for surgical reconstruction materials is also increasing day by day. The clinical effect of autologous transplantation is good, which guarantees the success of clinical treatment of bone defects, nonunions, and spinal fusion. It is known as the gold standard for bone defect repair. However, the limited source of autologous bone and the creation of new de...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C30B29/46C30B29/62C30B7/14A61L27/18A61L27/02A61L27/50A61L27/56A61L27/58
CPCC30B29/46C30B29/62C30B7/14A61L27/18A61L27/025A61L27/50A61L27/56A61L27/58A61L2430/02C08L67/04
Inventor 朱永展章培标郭敏李雪
Owner FOSHAN HOSPITAL OF TCM
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