An eyelid opening device convenient to adjust and used for ophthalmology nursing comprises a fixing plate, a contact plate is arranged in front of the fixing plate in a matched mode, threaded rods are movably installed on the two sides of the rear end of the contact plate respectively, two first screw holes are formed in the front face of the fixing plate, each threaded rod penetrates through the corresponding first screw hole, and two moving blocks are arranged in a frame in a matched mode. Contact blocks are installed at the rear ends of the opposite ends of the two moving blocks respectively, a control mechanism is arranged in the frame in a matched mode, and the control mechanism controls the two moving plates to move in the opposite direction or the opposite direction. According to the eyelid opening device, medical staff do not need to open eyelids with hands, physical labor of the medical staff is reduced, the situation that the medical staff pulls the eyelids all the time, and the eyelids are closed due to fatigue and hand looseness is avoided, adjustment can be conducted according to head shapes and eye positions of different patients, the frame can be independently taken down, and the operation is convenient. Disinfection treatment can be carried out, and the cleaning process is convenient.