The invention relates to a composite bone
repair material, a preparation method and application, the preparation method comprises the following steps: immersing silkworm cocoons in a
soap salt solution for degumming,
drying to prepare degummed silk, dissolving the degummed silk in a
lithium bromide solution, dialyzing for desalting, and concentrating to obtain a regenerated silk
protein solution; mixing the regenerated silk
fibroin solution with a
gelatin solution to obtain a gel solution; mechanically shaking the gel solution, so that the gel solution is uniformly mixed, uniformly distributed bubbles are formed in the gel solution, and a silk
protein /
gelatin gel block is obtained; soaking and cleaning the silk
protein /
gelatin gel block in an
ammonium sulfate solution to obtain silk protein / gelatin cross-linked gel; and freeze-
drying the
fibroin / gelatin cross-linked gel to obtain the
fibroin / gelatin
composite material. The composite bone
repair material has the advantages that the composite bone
repair material has a bionic porous structure, has excellent mechanical properties and also has good
biocompatibility and osteogenic activity. The material can be applied to filling and regeneration repair of
skull defects of the orthopedics department, the
oral cavity, the
plastic surgery (maxillofacial) and the
neurosurgery department, and has high industrial production and clinical application prospects.