The invention discloses a device and a method for data cross-system processing on the basis of a natural language industry knowledge base. An industry knowledge base based on natural language is built, and in addition, knowledge items are associated with the natural language word and grammar and the information system function, so that the function operation of each information system is associated to be the industry natural language, in addition, a data query device is used for executing operations of test query and use query on information system data sent by a logic association module, and an integral data processing module records integral data, so a user can conveniently carry out various cross-system operations such as query, data exchange and flow process processing on service data. The device and the method have the advantages that the interface development among the systems can also be avoided, and the problem of data butt joint incapability after the updating of a certain system is also avoided, so the cross-system data processing efficiency is improved.