The present disclosure relates to identification of previously known genes as being genes upregulated by
interferon-α administration, in particular the human genes corresponding to the cDNA sequence in
GenBank designated g4758303, g5453897, g4505186, g2366751, g33917, g4504962, g3978516, g5924396, g4505656, g1504007, g3702446, g4001802, g292289, g4557226, g4507646 and g4507170. Determination of expression products of these genes is proposed as having utility in predicting responsiveness to treatment with
interferon-α and other interferons which act at the Type 1
interferon receptor.