The invention provides a diagnostic system and device of an automatic medicine selling machine. First information of a user is acquired, first demand information of the user is acquired according to the first information, wherein the first demand information comprises medicine information and illness state information, a first diagnostic device is determined according to the first demand information, the first diagnosis information is acquired according to auxiliary diagnosis of the first diagnostic device, and a first final medicine is acquired according to the first diagnosis information, the first demand information and the first information. According to the system and device, through acquiring identity information of the user, conventional diagnosis and treatment are conducted on theuser according to the demand of the user, so that the medicine information needed by the user can be diagnosed, the technical problem that an existing automatic medicine selling machine can only simply sell medicine but cannot provide simple diagnosis and recommend medicine for the user can be solved, so that the intelligent service of simply diagnosing the user and recommending the related medicine for the user can be achieved, and the technical effects of improving user experience, convenience and high efficiency are achieved.