The invention discloses a smoke pesticide spraying machine which comprises a feeding port, a pesticide mixing chamber, a stirring device, a smoke outlet, an oil tank and a back plate. The lower end of the feeding port is connected with the pesticide mixing chamber, the stirring device is installed in the pesticide mixing chamber, the lower end of the stirring device is connected with a vapor-liquid atomizing chamber through a water outlet conduit, an eddy bin is installed in the vapor-liquid atomizing chamber, an air compressor is installed at the right end of the eddy bin, the right end of the air compressor is provided with an air inlet, a control switch is installed on the lower portion of the air inlet, a smoke outlet is arranged at the tail end of the left side of a smoke conduit, the oil tank is installed on the lower portion of the eddy bin, and the back plate is installed on the right side of the oil tank. According to the smoke pesticide spraying machine, air and pesticide solution are mixed and compressed into smoke by utilizing the air compressor, suspension time of the pesticide in air is increased, the pesticide gives full play to its pesticide property to kill pests, so that the pest-killing efficiency of the pesticide is improved, and the pesticide waste rate is reduced.