The invention discloses a pressure coefficient prediction method and system of a marine mud shale formation. The pressure coefficient prediction method of a marine mud shale formation includes the steps: preparing the drilling data, the logging data and the seismic data; for an overpressure shale formation, selecting a sensitive logging curve, and acquiring the longitudinal wave speed and the transverse wave speed; based on the drilling data, analyzing the relation between drilling density and the longitudinal wave speed, acquiring a Gardner formula, optimizing a Fillippone formula, obtainingan optimized Fillippone formula, and performing fitting on the coefficients in the optimized Fillippone formula; based on the transverse wave speed, performing re-optimization on the optimized Fillippone formula, obtaining a re-optimized Fillippone formula, and performing fitting on the coefficients in the re-optimized Fillippone formula; and based on the re-optimized Fillippone formula, predicting the formation pressure coefficient. The pressure coefficient prediction method of a marine mud shale formation performs quantitative evaluation research on the shale gas preservation conditions, cancomplete and deepen the shale gas dessert prediction technique sequence, and can realize optimization of the shale gas high-yield enrichment region.