The invention discloses a high-yield cultivation method of annual Angelica sinensis. The method comprises the steps of seedbed settling, sowing and seedling raising, seedling raising management, temporary planting seedling discharging, field transplanting, field management and harvesting and processing. When the cultivation method is used for planting Angelica sinensis, planting cost is low, investment risks are small, after transplanting, survival rate is high, the growth vigor of plants is strong, a planting cycle is short, technology practicability is high, the method is suitable for large-area promotion planting, meanwhile, compared with the prior art, under the situation that quality and pesticide effect are not changed, yield and quality are obviously improved, the occurring rate of plant diseases and insect pests is low, pesticide residual quantity is small, pollution is small, a good foundation is laid for improving manual large-scale planting of Angelica sinensis and enhancing the product competitiveness of Angelica sinensis, and great economic benefit, social benefit and ecological benefit are achieved.