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Conductive polyaniline with bioactivity, preparation thereof and use thereof

A conductive polyaniline and biologically active technology, applied in the direction of material analysis, instruments, and measuring devices through electromagnetic means, can solve the problem that free radical polymerization cannot control the molecular weight and macromolecular structure well

Inactive Publication Date: 2012-01-25
WUXI ZHONGMEI YIXIN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the existence of chain transfer and chain termination reactions, traditional free radical polymerization cannot control the molecular weight and macromolecular structure well

Method used

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  • Conductive polyaniline with bioactivity, preparation thereof and use thereof
  • Conductive polyaniline with bioactivity, preparation thereof and use thereof
  • Conductive polyaniline with bioactivity, preparation thereof and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1: Preparation of aniline derivative monomers with biologically active units

[0034] Dissolving biotin glycol phosphoramidite in anhydrous acetonitrile, then adding anhydrous acetonitrile solution of aniline-o-methanol, wherein: the molar ratio of biotin glycol phosphoramidite to aniline-o-methanol is 10:1~1:10 Add an appropriate amount of 5-ethylthiotetrazolium (ETT) activator, so that the concentration of the formed activator anhydrous acetonitrile solution is 0.25mol / L; after stirring at room temperature for 30 minutes, carry out vacuum distillation to powder Add excess oxidation solution, the oxidation solution is dissolved in tetrahydrofuran by elemental iodine: water: triethylamine = 8: 1: 1 mixed solvent to form, the mass percent concentration of the solution is 4%; after stirring at room temperature for 10 minutes , reduced to neutral with sodium thiosulfate, then evaporated tetrahydrofuran under reduced pressure, extracted with chloroform, dried the or...

Embodiment 2

[0037] Example 2: Preparation of bioactive conductive polyaniline

[0038] Mix the prepared aniline monomer with a biotin substituent with 1 to 10 times the molar amount of aniline and an appropriate amount of potassium chloride as an electrolyte, with a pulse of 10 milliseconds on and 10 milliseconds off, at 1.0 volts, 30 Copolymerization is carried out on the electrode by means of in-situ synthesis and electrochemical deposition in less than 1 second to obtain bioactive conductive polyaniline.

[0039] The electrode used in the embodiment is platinum metal, which can be made of iridium or other metals (for example: palladium, gold, silver, copper, mercury, nickel, zinc, titanium, tungsten, aluminum) or stainless steel, metal alloys, carbon nanotubes, glassy carbon , Reticular glassy carbon, graphite, doped oxide, indium tin oxide, silicon oxide, gallium arsenide semiconductor, metal-doped polymer or ceramic material.

Embodiment 3

[0040] Embodiment 3: Preparation of functionalized microelectrode array

[0041] Build microelectrode arrays on individually addressable logic circuit chips (see figure 1 As shown), each electrode on this circuit is connected by a switch of a CMOS (complementary metal oxide semiconductor) transistor, by sending an electronic address signal to the common node circuit and then to the SRAM (static random access) associated with each electrode memory) to turn on the switch; the microelectrode array is placed in a specially designed fluid reactor, and the reaction liquid in the reactor is 1 to 10 times the molar amount of the prepared aniline monomer with biotin substituent The computer digitally instructs the microelectrode array to respond to digital commands to assemble the conductive polymer; once the electrode is called, the conductive polymer immediately under the control of the logic circuit under the electrode Generated rapidly in situ, rinsed with deionized water and drie...

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Abstract

The invention discloses an in-situ electrochemical combinatorial synthesis method, which is adopted to copolymerize a phenylamine derivative monomer with bioactive units and phenylamine in solution in a manner of active radical polymerization on an electrode to form conductive polyaniline with bioactivity in situ on the electrode directly by one step, a microelectrode array technique adopting independent addressing and technique for preparing functional microelectrode arrays by using the conductive polyaniline with bioactivity. The method and the techniques solve the long-existing problem of the academic circles that the bioactive unit can be actively and permanently combined with a metal while bioactive molecules can be grafted with a conductive polymer in place by one step, lay a function for unmarked analysis methods, make biosensors develop toward microminiaturization and integration, make the automatic production of protein chips on an operable level possible, promote the development of things Internet industrial chain and have a profound social significance and high market value.

Description

technical field [0001] The present invention relates to a kind of conductive polyaniline with biological activity and its preparation method and application, specifically, it relates to a method of in-situ electrochemical combination synthesis (combinatorial synthesis) to make aniline derivatives with biologically active units The body is copolymerized with aniline in the solution on the electrode by living radical polymerization, and the conductive polyaniline with biological activity is directly generated in situ on the electrode in one step, and the independently addressable microelectrode array technology is used to apply the described bioactive polyaniline. Preparation of functionalized microelectrode arrays with active conductive polyaniline. Background technique [0002] Due to their special structure and excellent physical and chemical properties, conductive polymers have broad application prospects in the fields of optics, electromagnetism and chemistry. In recent ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G73/02G01N27/327
Inventor 王巍
Owner WUXI ZHONGMEI YIXIN BIOTECH
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