Method for preparing 5-hydroxymethylfurfural with fructose

Abstract

The invention discloses a method for preparing 5-hydroxymethylfurfural with fructose. The method includes the following steps: taking N, N-dimethyl acetamide as solvent, lithium chloride as additive, fructose as a reaction material, and heteropoly acid loaded by titanium dioxide as a catalyst, reacting at the temperature of 80-150DEG C to generate 5-hydroxymethylfurfural. The method has the characteristics of few by-products, high yield, environment-friendly property, moderate reaction conditions, small corrosion to equipment, recyclability of catalyst, and the like, and has industrial prospect.

Description

technical field [0001] The invention relates to the field of biomass green conversion synthetic compounds, in particular to a method for preparing 5-hydroxymethylfurfural from fructose. Background technique [0002] At present, most of the energy and organic chemical raw materials needed in the world come from petroleum, coal and natural gas. These fossil resources have made great contributions to social development and economic prosperity. However, with the gradual depletion of non-renewable fossil energy and in order to achieve the purpose of sustainable development of human beings, making full use of renewable and degradable resources and making them an important industrial raw material through chemical synthesis is the solution to resource depletion and environmental pollution. effective means. Biomass resources have large reserves, are renewable, and are low in cost. Through chemical synthesis, high value-added pharmaceutical intermediates and monomers for synthetic p...

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Problems solved by technology

[0004] There are some literature reports on the preparation of 5-hydroxymethylfurfural from six-carbon sugar: the Chinese patent application with application number CN200910228921.2 discloses a preparation of isomerase / dilute hydrochloric acid coupling catalyzed glucose to prepare 5-hydroxymethylfurfural The method, the steps of the method are as follows: firstly add sodium borate and immobilized glucose isomerase to the glucose solution to react, then filter, recover the isomerase to obtain a mixed solution of glucose and fructose, add hydrochloric acid, Sodium chloride and n-butanol carry out acid-catalyzed synthesis of 5-hydroxymethylfurfural; the disadvantage of this method: the price of isomerase is relatively expensive, and in the reaction process, the temperature is not easy to control, and the activity of the enzyme is easy to fail

A Chinese patent application with the application number CN 200810011726.X discloses a method for preparing 5-hydroxymethylfurfural. The patent uses a saturated sodium chloride-n-butanol system as a reaction solvent, phosphotungstic acid as a catalyst, and fructose Converted to 5-hydroxymethylfurfural; the disadvantage of this method: the catalyst phosphotungstic acid is not easy to recycle, and the product yield is not very high

The Chinese patent application with the application number CN200710158825.6 discloses a method for preparing 5-hydroxymethylfurfural. The method uses ionic liquid 1-methyl-3-alkylimidazolium bromide as reaction solvent, and acidic ionic liquid (Imidazole hydrogen sulfate, 1-methyl-3-butyl imidazole hydrogen sulfate), inorganic acids (hydrochloric acid, nitric acid, phosphoric acid) and organic acids (formic acid, acetic acid, citric acid) as catalysts to catalyze the dehydration production of six carbon sugars 5-Hydroxymethylfurfural; the disadvantage of this method: the viscosity of the ionic liquid is relatively high, the price is relatively expensive, and inorganic acids such as hydrochloric acid and sulfuric acid are relatively acidic, which is relatively serious for equipment corrosion, and is not easy for industrial production

[0005] The Chinese patent application with the application number CN 200710158826.0 discloses a microwave-promoted method for preparing 5-hydroxymethylfurfural, using ionic liquid 1-ethyl-3-methylimidazolium bromide as a solvent, microwave power 200-2000W , Under the conditions of reaction temperature 50-100°C and reaction time 0.5-30min, biomass monosaccharides are dehydrated to produce 5-hydroxymethylfurfural; the disadvantages of this method: (1) Microwave heating can only be produced in small batches, Large-scale production cannot be realized; (2) The viscosity of ionic liquid is relatively high and the price is relatively expensive, so it can only be limited to laboratory research as a solvent