Protein antimicrobial catheter and manufacturing method thereof

A urinary catheter and protein technology, applied in catheters, coatings and other directions, can solve the problems of complex surface coating treatment process, weak persistence of antibiotics, affecting bacteriostatic and antibacterial efficacy, etc. The effect of reducing treatment time and reducing physical pain

Active Publication Date: 2014-05-07
SUZHOU RYAN NANOMEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the price of this type of catheter is lower than that of metal ion / alloy coated catheter, it still has the following disadvantages: the sustained release of antibiotics has weaker potency, and long-term use may lead to the emergence of antibiotic-resistant bacteria and affect its antibacterial, Antibacterial efficacy
However, these bacteriostatic and antibacterial coated urinary catheters still have the disadvantages of complex surface coating treatment process, which may bring in toxic substances and affect human health.

Method used

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  • Protein antimicrobial catheter and manufacturing method thereof
  • Protein antimicrobial catheter and manufacturing method thereof
  • Protein antimicrobial catheter and manufacturing method thereof

Examples

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preparation example Construction

[0039] Further in the preparation method of the above-mentioned protein antibacterial catheter, the natural protein is serum albumin, silk fibroin, whey protein, collagen, walbumin, ovalbumin, soybean albumin, lysozyme One or more; the solvent is an aqueous solution of water or ethanol, ethylene glycol, glycerin, mannitol, sodium chloride, calcium chloride, sodium bicarbonate; the non-protein natural substance is chitin, chitosan Sugar or its derivatives are added in an amount of 1% to 5% of the total weight of the initial glue; the cross-linking agent is one or more of carbodiimide, N-hydroxysuccinimide or genipin Combination, its addition is 0.5%~1.5% of the initial glue total weight; The thickener is one or more combinations of sodium carboxymethyl cellulose, xanthan gum or sodium alginate, and its addition is 0.5% to 1.5% of the total weight of the initial glue; the dispersant is one or more combinations of sodium tripolyphosphate, polyethylene glycol 400 or Tween 60, and ...

Embodiment 1

[0042] Protein antibacterial catheter, the preparation process is as follows:

[0043] Catheter pretreatment: Take a complete silicone rubber catheter raw material, wash it repeatedly with distilled water 5 to 6 times, and then completely immerse it in Piranha lotion (98% concentrated sulfuric acid and 30% hydrogen peroxide solution 3:1 (v / v) mixed solution) in a water bath at 60°C for 30 min.

[0044] Preparation of protein glue: mix soluble powders of whey protein, wheat albumin, lysozyme, and carboxymethyl chitosan in a certain mass ratio, such as 1.5:5:3:0.5, and add them into distilled water to obtain the total mass fraction 2wt% to 20wt% of the initial glue, then according to the volume of the protein glue, add 5mg / ml polyethylene glycol 400 aqueous solution in a ratio of 50:1 (v / v) as a dispersant, and use a magnetic stirrer for the solution Stir for 1 hour to obtain a secondary glue, and finally filter and centrifuge the secondary glue successively to remove air bubbl...

Embodiment 2

[0048] Protein antibacterial catheter, the preparation process is as follows:

[0049] Pretreatment of urinary catheter: Take a complete latex urinary catheter, wash it repeatedly with 80% (v / v) ethanol aqueous solution for 5 to 6 times, let the catheter dry naturally, and then use ethylene oxide to dry it. It was sterilized at 50° C. for 10 minutes, and then placed in a continuous radio frequency low-temperature plasma apparatus to treat the surface of the catheter. The plasma discharge power and time were 200 W and 5 minutes, respectively.

[0050] Protein glue preparation: mix the soluble powders of silk fibroin, whey protein, wheat albumin and ovalbumin according to a certain mass ratio, such as 1:4:3:2, and add 20% (v / v) Ethylene glycol solution is used as a solvent to obtain an initial glue solution with a total mass fraction of 5wt% to 20wt%, and then 0.01mol / L sodium tripolyphosphate solution is added in a ratio of 50:1 (v / v) according to the volume of the protein glue...

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Abstract

The invention discloses a protein antimicrobial catheter. A non-diffusivity nanoscale smooth coating is arranged on the surface of the material of the catheter body, the main ingredient of the coating is natural protein harmless to the human body, the thickness of the coating is 10 nm to 500 nm, and the RMS roughness of the coating is not larger than 100 nm. The invention further discloses a manufacturing method of the protein antimicrobial catheter. The method includes the main steps that the material of the catheter body is pre-processed, protein glue solution is prepared, the surface of the material of the catheter body is coated with the protein glue solution one time or multiple times, and finally the protein glue solution adhering to the surface of the material of the catheter body is cured with the method of natural curing or microwave curing or hot curing or ultraviolet curing or cross-linking curing or the like. The catheter manufactured with the method is excellent in bacteria resistance and antibacterial effects, economical burdens and body pains caused when a catheter is frequently replaced for a patient can be reduced, the catheter is good in stability and low in virulence in body, some discomfort symptoms will not be caused to the patient, and the catheter is safe in clinical use.

Description

technical field [0001] The invention relates to a medical antibacterial urinary catheter and a preparation method of the catheter, specifically refers to the use of antibacterial protein glue to form a protein nano-coating and adhere to the surface of the urinary catheter to obtain an antibacterial Bacteria catheter, thereby effectively inhibiting the adhesion and growth of various bacteria and molds during the use of the catheter in the body. Background technique [0002] Medical catheters are one of the most commonly used medical devices in clinical practice. Although they are widely used, the related infections caused by indwelling catheters are common and difficult problems in clinical treatment, especially long-term catheters, which account for about 10% of the total. Indwelling catheters are more prone to the above problems, and 75% to 80% of urinary tract infections are caused by catheters. The traditional methods to deal with infection caused by urinary catheters in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/00A61L29/08
Inventor 赵鹏文学军李寅莹刘静
Owner SUZHOU RYAN NANOMEDICINE
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