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Nanoporous network fibers prepared by high-voltage electrospinning and their applications

A high-voltage electrospinning and nanofiber technology, which is applied in fiber processing, rayon manufacturing, fiber chemical characteristics, etc., can solve the problems of unfavorable mass industrial production, increase of specific surface area of ​​fiber support, unfavorable calcium salt deposition, etc., and achieve good Biodegradability, good biocompatibility, effect of increasing specific surface area

Active Publication Date: 2017-02-01
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the uneven dispersion of β-TCP in the fiber, the mechanical properties of the nanofibers decrease with the increase of the content of β-TCP, and at the same time, the surface of the obtained fiber also forms more knots due to a large number of β-TCP clusters.
The reduction of mechanical properties and poor surface morphology both affect the application of this fiber
[0006] The electrospun fibers mentioned above and most other electrospun fibers have a smooth surface and no nanopores, which not only limits the further increase of the specific surface area of ​​the fibrous scaffold, but also is not conducive to calcium absorption when used as a scaffold for articular cartilage repair. salt deposition
[0007] Can form so-called nanometer " hole " method (Silke Megelski, Jean S.Stephens, D.Bruce Chase, and JohnF.Rabolt. on Electrospun PolymerFibers.Macromolecules, 2002, 35, 8456-8466.), on the one hand, there are only some nanometer-sized "blind holes" closed at one end formed on the surface of nanofibers; Poor repeatability, not conducive to mass industrial production
[0008] For example, in 2007, CN2921043Y introduced "a fiber with nanopores prepared by electrospinning". Although the patent also mentioned that the surface of the resulting fiber had nanopores, the patent did not give a specific preparation method. , and no information such as the shape detection of nanopores on the surface of the fiber is given, so this technology has no feasibility and practical value

Method used

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  • Nanoporous network fibers prepared by high-voltage electrospinning and their applications
  • Nanoporous network fibers prepared by high-voltage electrospinning and their applications
  • Nanoporous network fibers prepared by high-voltage electrospinning and their applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] First add TTCP to 40ml of toluene and ultrasonically treat it until it is fully dispersed, then add L-lactide (L-lactide) and at the same time add 0.2% Sn(Oct) based on the total mass of L-lactide and TTCP 2 , heated up to 110°C for 2 hours, the mass ratio of L-lactide to TTCP was 97.5:2.5, the resulting product was precipitated in petroleum ether at -20°C, filtered by suction, and dried in vacuum; the dried product was placed in a cable Extract with dichloromethane in an extractor until no characteristic peak of the PLLA molecular group can be detected in the extract by nuclear magnetic resonance analysis, and the obtained L-polylactic acid-tetracalcium phosphate is dried in a vacuum oven for later use.

[0043] The viscosity-average molecular weight after vacuum drying in a mass ratio of 40:40:20 is 5×10 4 Polypropylene carbonate with a viscosity average molecular weight of 5×10 4 The polycaprolactone pellets are mixed with L-polylactic acid-tetracalcium phosphate, a...

Embodiment 2

[0045] First add TTCP to 40ml of toluene and ultrasonically treat it until it is fully dispersed, then add L-lactide, and at the same time add 0.3% Sn(Oct) based on the total mass of L-lactide and TTCP 2 , the temperature was raised to 135° C. for 9 hours, and the mass ratio of L-lactide to TTCP was 92.5:7.5. The post-treatment of the obtained product was the same as that in Example 1, and was omitted here.

[0046] The viscosity-average molecular weight after vacuum drying with a mass ratio of 77:15:8 is 6×10 4 Polypropylene carbonate, viscosity average molecular weight is 6×10 4 The polycaprolactone pellets are mixed with L-polylactic acid-tetracalcium phosphate, and 0.15% titanium tetrachloride and 0.15% lithium bromide based on the total mass of the previous three materials, and then added chloroform: ethyl acetate: DMSO is 80: A mixed solution with a concentration of 14% was prepared in a mixed solvent of 3:17; the prepared mixed solution was placed in an electrospinning...

Embodiment 3

[0048] First add TTCP to 50ml of toluene and ultrasonically treat it until it is fully dispersed, then add L-lactide, and at the same time add 0.3% Sn(Oct) based on the total mass of L-lactide and TTCP 2 , the temperature was raised to 120° C. for 7 hours, and the mass ratio of L-lactide to TTCP was 95:5. The post-treatment of the obtained product was the same as in Example 1, and was omitted here.

[0049] The viscosity-average molecular weight after vacuum drying with a mass ratio of 70:20:10 is 6×10 4 Polypropylene carbonate with a viscosity average molecular weight of 1×10 5 The polycaprolactone pellets were mixed with L-polylactic acid-tetracalcium phosphate, and 0.5% titanium tetrachloride based on the total mass of the previous three materials, and then added chloroform: ethyl acetate: DMF with a ratio of 88: 2: 10 A mixed solution with a concentration of 10% is prepared in a mixed solvent; the prepared mixed solution is placed in an electrospinning device connected to...

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Abstract

The invention discloses a fibre containing nanopore network prepared from high voltage electrostatic spinning. The fibre containing nanopore network is prepared from the following steps: blending the polypropylene carbonate, polycaprolactone and L-polylactide-tetracalcium phosphate at a mass ratio of (40-98):(1-40):(1-20) and a conductive metal salt which accounts for 0.2-0.5% of the total mass of the three materials, and preparing from a high voltage electrostatic spinning method; the electron microscopy image shows that the fibre is formed by a plurality of mutually connected nanopore networks, and the specific surface area is 115.76-180.45 m<2> / g. The invention further discloses application of the nanopore network fibre in the cartilage tissue engineering. The mutually connected nanopore networks can be formed at the surface and interior of the fibre, so that the specific surface area is increased; because of the good biocompatibility and biodegradability, the cartilage growth capability in the cartilage tissue engineering can be well guided. The fibre containing nanopore network is simple in preparation method, controllable and convenient for mass industrial production.

Description

technical field [0001] The invention belongs to the technical field of preparation and application of high-voltage electrospinning fibers, and in particular relates to a nanopore network fiber prepared by high-voltage electrospinning and its application in cartilage tissue engineering. Background technique [0002] Mature cartilage is a kind of avascular tissue, and adult cartilage widely exists in the articular surface of bone, costal cartilage, trachea, auricle, intervertebral disc, etc. Articular cartilage is composed of 1% chondrocytes and 99% extrachondral matrix, which is composed of collagen, proteoglycan and water. Since articular cartilage has no blood vessels and lymphatic vessels to provide nutrients, and chondrocytes have limited self-proliferation ability, when the joint is traumatized or degenerated, the composition and metabolism of chondrocytes and matrix will change accordingly. Among them, the metabolic changes are manifested by the reduction of chondrocyt...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/26A61L27/50D01D5/00D04H1/728D01F6/92D01F1/10
Inventor 郭刚陈海峰王跃龙邓佼姣周良学仝爱平魏于全
Owner SICHUAN UNIV
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