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Drug-loaded polymer/calcium-phosphorus composite coating and preparation of degradable magnesium-based intraosseous implants

A technology of polymer coating and composite coating, which is applied in coating, metal material coating technology, medical science, etc., can solve the problems of ineffective drug loading, delay corrosion and degradation rate, reduce cost, and promote bone the effect of growth

Active Publication Date: 2020-05-22
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problem that the current bioactive calcium-phosphorus coating cannot effectively load drugs, and adds a layer of polymer drug carrier coating between the bioactive calcium-phosphorus coating and the substrate, which can meet the requirements of the outer bioactive calcium-phosphorus coating. The phosphorus coating improves the biocompatibility of the implant, promotes the formation of a direct chemical bond between the implant and the bone tissue, promotes the growth of the bone, and delays the corrosion and degradation rate of the matrix in body fluids. Loading drugs on the surface of magnesium alloys can treat a series of bone lesions, and the drug release rate can be adjusted by changing the thickness of the polymer coating, the drug loading and the thickness of the bioactive calcium-phosphorus coating; the operation process is simple and easy, and the preparation Strong coating and substrate bonding force, thickness controllable

Method used

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  • Drug-loaded polymer/calcium-phosphorus composite coating and preparation of degradable magnesium-based intraosseous implants
  • Drug-loaded polymer/calcium-phosphorus composite coating and preparation of degradable magnesium-based intraosseous implants
  • Drug-loaded polymer/calcium-phosphorus composite coating and preparation of degradable magnesium-based intraosseous implants

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] A degradable polymer carrier for drug loading and a bioactive calcium-phosphorus composite coating were prepared on the surface of pure Mg. figure 1 , including a magnesium substrate 4 , a fluoride film 3 , a biodegradable polymer coating 2 and a bioactive calcium-phosphorus coating 1 . When preparing, first make pure magnesium into The samples were polished with 320-mesh, 1200-mesh and 3000-mesh water sandpaper in turn. Ultrasonic cleaning with absolute ethanol and acetone for 10 min, respectively, and drying. Soak the sample in 40% HF solution at room temperature for 24 hours, wash it with deionized water and absolute ethanol successively, and dry it. Take polytrimethylene carbonate (PTMC) with a weight-average molecular weight of 80000-100000, dissolve it in ethyl acetate solvent at a ratio of 8wt.%, and uniformly coat polytrimethylene carbonate on the fluorinated The surface of pure magnesium was treated, and the pure magnesium coated with polytrimethylene carbo...

Embodiment 2

[0052] A degradable polymer carrier for drug loading and a bioactive calcium-phosphorus composite coating were prepared on the surface of AZ31 (Mg-Al series) alloy. Firstly, the AZ31 magnesium alloy is made into The samples were polished with 320-mesh, 1200-mesh and 3000-mesh water sandpaper in turn. Ultrasonic cleaning with absolute ethanol and acetone for 10 min, respectively, and drying. The sample was soaked in a 40% HF solution in a water bath at a constant temperature (20°C) for 14 hours, washed with deionized water and absolute ethanol successively, and dried. Take racemic polylactic acid (PDLLA) with a weight-average molecular weight of 100000-150000, dissolve it in ethyl acetate solvent at a ratio of 6wt.%, and dissolve paclitaxel at a ratio of 2wt.%. The polylactic acid solution of paclitaxel drug is evenly coated on the surface of the fluorinated magnesium alloy, and the magnesium alloy coated with the paclitaxel-loaded polylactic acid coating is placed in a vacu...

Embodiment 3

[0054] A degradable polymer carrier for drug loading and a bioactive calcium-phosphorus composite coating were prepared on the surface of Mg-Nd-Zn-Zr alloy. Firstly, the Mg-Nd-Zn-Zr magnesium alloy is made into The samples were polished with 320-mesh, 1200-mesh and 3000-mesh water sandpaper in turn. Ultrasonic cleaning with absolute ethanol and acetone for 10 min, respectively, and drying. The sample was soaked in a 20% HF solution in a water bath at a constant temperature (20°C) for 8 hours, washed with deionized water and absolute ethanol successively, and dried. Take polylactic acid-glycolic acid copolymer (PLGA) with a weight average molecular weight of 80000-100000, dissolve it in ethyl acetate solvent at a ratio of 8wt.%, and dissolve paclitaxel at a ratio of 2wt.%. The PLGA solution mixed with paclitaxel is evenly coated on the surface of the fluorinated magnesium alloy, and the magnesium alloy coated with the PLGA coating is placed in a vacuum drying oven at 35°C fo...

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Abstract

The invention discloses a degradable magnesium-based bone implant drug-loaded high molecular / calcium-phosphorus composite coating and a preparation method. From inside to outside, the composite coating comprises a fluorinated film on the surface layer of a bone implant, a biodegradable high molecular coating and a bioactive calcium-phosphorus coating; and the preparation method comprises the following steps: soaking a magnesium or magnesium alloy bone implant in hydrofluoric acid at constant temperature, so as to form a fluorinated protective layer; dissolving a biodegradable high molecular material in an organic solvent, coating the dissolved biodegradable high molecular material on the surface of the fluorinated bone implant by virtue of an extracting method, and conducting vacuum drying so as to obtain a polymer coating; and conducting ultraviolet ozone or plasma surface pre-treatment on the bone implant coated with the polymer coating, and soaking the bone implant in phosphate mixed liquid at constant temperature. According to the composite coating prepared by the invention, the surface bio-activity of magnesium or magnesium alloy which serves as a base is enhanced and the corrosion rate of the base is reduced; meanwhile, a degradable carrier is provided for drug loading of the bone implant material; the preparation method is simple, convenient and easy in operating process; and the prepared coating is strong in bonding force with the base and is controllable in thickness.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical materials, in particular to a degradable magnesium-based intraosseous plant drug-loading macromolecule / calcium-phosphorus composite coating and its preparation. Background technique [0002] In the field of orthopedic implants, magnesium and magnesium alloy implant materials are expected to replace orthopedic implant materials such as stainless steel, titanium and titanium alloys in traditional medicine. Compared with other medical metal materials, magnesium and magnesium alloys have the following advantages: 1) Degradability. Magnesium alloys have a low corrosion potential, and are prone to corrosion in an in vivo environment containing chloride ions, and are completely degraded in the body in a slow corrosion manner, which can realize the degradation and absorption of magnesium in the human body. 2) High biological safety. As an essential nutrient element for the human body, ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/32A61L27/54A61L31/10A61L31/08A61L31/16C23C22/02C23C22/82C23C22/07
Inventor 裴佳张磊袁广银
Owner SHANGHAI JIAO TONG UNIV
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