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PH/zinc ion and redox quadruple stimuli responsive nanocontainer and preparation method thereof

A stimuli-responsive, nano-container technology, which can be used in pharmaceutical formulations, inactive medical preparations, inorganic inactive ingredients, etc., can solve problems such as weak coordination, and achieve the effects of low toxicity, convenient preparation, and extended service life.

Inactive Publication Date: 2017-09-15
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In brain extracellular fluid, free zinc is about 500×10 -9 mol / L concentration; however, in synaptic vesicles called "zinc-containing" neurons, more than 1 × 10 -3 mol / L concentration, and only weakly coordinate with any endogenous ligand

Method used

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  • PH/zinc ion and redox quadruple stimuli responsive nanocontainer and preparation method thereof
  • PH/zinc ion and redox quadruple stimuli responsive nanocontainer and preparation method thereof
  • PH/zinc ion and redox quadruple stimuli responsive nanocontainer and preparation method thereof

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preparation example Construction

[0037] References for the preparation method of mesoporous silica nanospheres of the present invention [C D Ding; Y Liu; M DWang; T Wang; J J Fu; Superhydrophobic Coating Based on Mechanized Silica Nanoparticles for Reliable Protection of Magnesium Alloy[J].J. Am.Chem.Soc.,2016,4(21):8041-8052], the specific steps are as follows:

[0038] With 0.5g cetyltrimethylammonium bromide (CTAB), 1.75mL 2mol / L sodium hydroxide solution, 240mLH 2 O was added to a 500mL three-necked flask, heated to 80°C under vigorous stirring, and kept for 30 minutes to activate CTAB, and then 2.5mL tetraethyl orthosilicate (TEOS) was added dropwise. Under vigorous stirring, white precipitates gradually appeared in the reaction vessel. generate. React at 80°C for 2 hours, filter while hot, wash the solid with water and methanol several times, and dry it in vacuum. After drying, ultrasonically disperse the solid in a mixture of 100mL methanol and 5mL concentrated hydrochloric acid, stir the reaction so...

Embodiment 1

[0040] 1. Preparation of guest molecules

[0041] Phenol (5.00g, 53.19mmol), 1,4-dibromobutane (13.77g, 63.75mmol) and K 2 CO 3 (16g, 116mmol) the mixture in 30.0mL anhydrous acetonitrile in N 2 Reflux under atmosphere for 10h. Then the crude product was purified by a silica gel column, and the eluent was petroleum ether-dichloromethane (3:1, v / v) to obtain a white crystal product (4-bromobutoxy)benzene.

[0042] Cystamine dihydrochloride (6.75 g, 30 mmol) was dissolved in 300 ml of methanol; di-tert-butyl dicarbonate (6.54 g, 30 mmol) and triethylamine (12.60 mL, 3 equivalents) in 45 mL of methanol were dissolved, Add the above solution dropwise to the methanol solution containing cystamine dihydrochloride at a rate of 0.64 mL / min. After the addition was complete, the reaction mixture was stirred for another 90 min. The solvent was then removed by rotary evaporation and 1M NaH was added 2 PO 4 (75 mL); the aqueous solution was washed three times with ether (90 mL) to r...

Embodiment 2

[0058] 1. Preparation of guest molecules

[0059] Phenol (0.473g, 5mmol), 1,4-dibromobutane (1.32g, 6mmol) and K 2 CO 3 (1.53g, 11mmol) the mixture in 35.0mL anhydrous acetonitrile in N 2 Reflux under atmosphere for 24h. Then the crude product was purified by a silica gel column, and the eluent was petroleum ether-dichloromethane (3:1, v / v) to obtain a white crystal product (4-bromobutoxy)benzene.

[0060] Cystamine dihydrochloride (2.25 g, 10 mmol) was dissolved in 100 ml of methanol; di-tert-butyl dicarbonate (2.18 g, 10 mmol) and triethylamine (4.20 mL, 3 eq) in 15 mL of methanol were dissolved, Add the above solution dropwise to the methanol solution containing cystamine dihydrochloride at a rate of 0.64 mL / min. After the addition was complete, the reaction mixture was stirred for another 30 min. The solvent was then removed by rotary evaporation and 1M NaH was added 2 PO 4 (25 mL); the aqueous solution was washed three times with ether (30 mL) to remove the double-...

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Abstract

The invention discloses a pH / zinc ion and redox quadruple stimuli responsive nanocontainer and a preparation method thereof. The nanocontainer adopts silica nanoparticles as the skeleton, then a host-guest compound can be formed based on a host molecule pillar[5]arene and a guest molecule chain 2-[(2-aminoethyl)dithio]-N-phenoxybutane-ethylamine, the microsphere surface is modified with a supramolecular valve, and the microsphere is internally loaded with rhodamine B. PH / Zn<2+> can stimulate the movement of the macrocyclic molecule pillar[5]arene in the nanocontainer, when a reducing substance cuts off a disulfide bond, combination between the macrocyclic molecule and guest molecule can fail, thus realizing controlled release of RhB. The intelligent nanocontainer provided by the invention can realize the function of response to a variety of external stimuli, and can achieve response to pH / Zn<2+> and redox quadruple stimuli, thus having broad application prospects in drug delivery, intelligent anticorrosive coatings and other fields.

Description

technical field [0001] The present invention relates to a pH / Zn 2+ A redox-quadruple stimulus-responsive nano container and a preparation method thereof belong to the technical field of nano materials. Background technique [0002] The precise design of stimuli-responsive nanocontainers is developing rapidly but remains a challenge to adapt to complex environments. Based on their design concept, advanced stimuli-responsive nanocontainers combine "nanovalve" and "storage pool". Once the nanovalve captures the stimulus, they quickly open the door of the storage pool to release the entrained cargo, thereby accomplishing the intended task. Therefore, the cargo must be completely sealed to avoid unnecessary leakage. So far, stimuli such as pH, enzymes, redox, and light have been introduced into stimuli-responsive nanocontainers and the resulting controlled-release systems have been designed and operated. However, with the continuous expansion of application fields, traditional...

Claims

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Application Information

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IPC IPC(8): A61K47/02A61K47/06A61K47/20C23F11/00
CPCA61K9/0002A61K47/02A61K47/06A61K47/20C23F11/00
Inventor 傅佳骏仝玲丁晨迪杜娟王明东周文
Owner NANJING UNIV OF SCI & TECH
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