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A kind of biomimetic matrix hydrogel mask and preparation method thereof

A hydrogel mask and matrix technology, applied in the biological field, can solve the problems of loss of biological activity, long reaction time, body damage, etc.

Active Publication Date: 2021-09-21
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there are many reports on the development of collagen hydrogels as cosmetic products, but in the gel preparation process, it is inevitable to use different cross-linking agents such as glutaraldehyde, EDAC (carbodiimide) as cross-linking agents Gel formation, these cross-linking agents have limitations in their use
The active aldehyde group of glutaraldehyde will combine with organic molecules such as proteins in the body to make the latter lose their biological activity and cause damage to the body. When used in facial mask products, it is more likely to cause damage to relatively loose eye tissues
Although the literature reports that EDAC is non-toxic or less toxic, animal experiments have confirmed that the gel method is more toxic, because the by-products and residual EDAC in the cross-linking process cannot be removed.
In the patent application number 201310520057.X "a hydrogel capable of hydrolyzing and reversing collagen and its preparation method", it is mentioned that the glycosaminoglycans derived from aldylation and hydrazide are reacted with collagen, through The aldehyde group derivatization product and the amino NH2 on the collagen peptide chain are covalently bonded to form an imine, and then the in situ polymerization is realized by adding the glycosaminoglycan hydrazide product to embed the collagen molecule; but in the end, the real meaning must be formed On the collagen hydrogel, one or more cross-linking agents in divinyl sulfone, hydrazide compounds or carbodiimide need to be added, and the reaction time is longer

Method used

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  • A kind of biomimetic matrix hydrogel mask and preparation method thereof
  • A kind of biomimetic matrix hydrogel mask and preparation method thereof
  • A kind of biomimetic matrix hydrogel mask and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Acylated collagen: prepare an aqueous solution of type I collagen with a mass fraction of 5%, pH=7, configuration method: take the calculated collagen hydrochloric acid solution and dilute it with distilled water, adjust the pH value to pH=7 , and then set the volume to 5%. Take a certain amount of neutral 5% type I collagen aqueous solution and put it in a 200ml beaker, place it on a constant temperature magnetic stirrer, calculate according to the mass ratio of collagen: succinic anhydride is 100:10, weigh succinic anhydride, and add it in portions Collagen aqueous solution was added while stirring. During the reaction, the pH value was adjusted with 2moL / L NaOH solution to stabilize it at pH=7; after the addition, the reaction was continued for 3h to terminate, and the pH value was adjusted again to pH=7. Place the succinylated collagen in a dialysis bag in a refrigerator at 4°C for dialysis to remove small molecules and other impurities; stir while dialysis, and...

Embodiment 2

[0033] Test the collagen succinylation in step (1) of Example 1. Considering that the reaction conditions are as simple as possible, the reaction temperature is fixed at room temperature 20-25° C., and an aqueous solution of type I collagen with a mass fraction of 5% is prepared, and the pH value is studied respectively. (5, 7, 9), the amount of succinic anhydride (1%, 5%, 10% calculated according to the percentage of collagen protein mass), and the reaction time (1h, 2h, 3h) respectively affect the collagen succinylation modified collagen acylation degree of influence. The degree of acylation is tested according to the ninhydrin method: prepare a 1% collagen solution by mass fraction, take 1ml and put it into a test tube, and then add 1ml of ninhydrin chromogen to the test tube. Shake well, cover and stopper, heat in a boiling water bath for 16min, take it out, cool in a water bath at 20°C, and add 5ml of KIO to the test tube 3 Dilute the solution, shake it well, and use a 1...

Embodiment 3

[0039] (1) Collagen succinylation: configure a type I collagen aqueous solution with a mass fraction of 5%, pH=6.5, configuration method: take the calculated amount of collagen hydrochloric acid solution and dilute it with distilled water, adjust the pH value to 6.5, Then adjust the volume to 5%. Take a certain amount of neutral 5% type I collagen aqueous solution and put it in a 200ml beaker, place it on a constant temperature magnetic stirrer, calculate according to the mass ratio of collagen: succinic anhydride is 100:5, weigh succinic anhydride, and add in portions The collagen aqueous solution was added while stirring, and the pH value was adjusted to 6.5 with 2moL / L NaOH solution during the reaction process; after the addition, the reaction was continued for 3 hours to terminate, and the pH value was adjusted to 6.5 again. Place the succinylated collagen in a dialysis bag in a refrigerator at 4°C for dialysis to remove small molecules and other impurities; stir while dia...

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PUM

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Abstract

The invention relates to a bionic matrix hydrogel facial mask and a preparation method thereof. The raw materials are composed of the following substances in terms of mass ratio: composite collagen hydrogel, tragacanth gum powder, polysorbate-80, Kudingcha extract, Heather extract, Cistanche deserticola extract, mulberry polysaccharide and water. The biomimetic matrix hydrogel mask prepared by the present invention is safe, non-toxic, simple and convenient; the present invention adopts non-cytotoxicity and high water content, and does not need any additional cross-linking agent composite collagen hydrogel as the matrix, and reasonably added Kuding There are a lot of flavonoids in tea extract and heather extract, which can eliminate free radicals and resist aging due to their good antioxidant activity; Cistanche deserticola extract and mulberry polysaccharide not only have certain anti-aging effects, but also have whitening effects in suitable proportions .

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a biomimetic matrix hydrogel facial mask and a preparation method thereof. Background technique [0002] The mask raises the temperature of the skin by blocking the contact between the skin and the air, inhibiting sebum secretion and sweat evaporation. After the skin temperature rises, it will promote blood circulation, so that the active ingredients in the mask can penetrate into the epidermis or deeper and wider places. Accelerated blood circulation will make the skin rosy and shiny, and after the skin absorbs more water, nutrient essence and various active ingredients, it can effectively improve skin dehydration and dullness, reduce fine lines, delay skin aging, and to a certain extent It has the effect of removing freckles and acne; using the mask can also soften cutin, expand pores, promote sweat gland secretion and remove epidermal cell metabolites to achieve the effect of cleani...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/9789A61K8/73A61K8/65A61K8/04A61Q19/08A61Q19/02A61Q19/00
CPCA61K8/042A61K8/65A61K8/73A61K8/735A61K2800/30A61Q19/00A61Q19/02A61Q19/08A61K8/9789
Inventor 王富友张玲
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV