Artificial peptidomimetic as well as preparation method and application thereof

An artificial and pharmaceutical preparation technology, applied in the field of biomedicine, can solve problems such as heavy economic burden, and achieve the effects of easy industrialization, simple preparation process, and reasonable selection of raw materials
CN113024643AActive Publication Date: 2021-06-25WUHAN UNIV
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
WUHAN UNIV
Publication Date
2021-06-25

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Abstract

The invention provides an artificial peptidomimetic. The structural formula of the artificial peptidomimetic is as shown in formula 1. The invention also provides a preparation method and application of the artificial peptidomimetic. The preparation method provided by the invention is reasonable in raw material selection, easy to obtain, simple in preparation process and easy to industrialize. The artificial peptidomimetic provided by the invention can be used for preparing medicines for preventing or treating redness and swelling of joints or / and swelling of joints or / and bone erosion of joints or / and joint deformation or / and reduction of joint bone density, and can also be used for preparing medicines for preventing or treating and inhibiting inflammation-related cytokines IL-1beta or / and IL-8 or / and TNF-alpha.
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Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to an artificial peptide and its preparation method and application. Background technique

[0002] Rheumatoid arthritis (rheumatoid arthritis, RA) is a chronic systemic autoimmune disease, mainly causing joint tenderness, swelling and destruction, resulting in disability. The disease is prone to occur in women, and the age is mainly concentrated between 30-50 years old. Worldwide, about 1% of the population suffers from the disease. The lesions of RA are mostly small joints, which have the characteristics of symmetrical distribution. The early clinical symptoms are mainly redness, pain, and limited range of motion. As the disease progresses, the joint mobility gradually decreases, and some patients lose their joint mobility completely. . If the condition is not well controlled, RA may also lead to organ involvement other than joints, such as: keratitis, rheumatoid nodules, pericarditis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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