Polyetheretherketone composite implant as well as preparation method and application thereof

Abstract

The invention discloses a polyetheretherketone composite implant as well as a preparation method and application thereof. The composite implant comprises a polyetheretherketone substrate, a degradable polymer coating wrapping the surface of the polyetheretherketone substrate, and a functional substance loaded and / or grafted by the degradable polymer coating; the functional substance comprises a substance with an immune regulation function and / or a substance with an osteogenesis regulation function. The preparation method comprises the following steps: constructing the degradable polymer coating loaded with the functional substance on the surface of the polyetheretherketone substrate; modifying and activating the surface of the degradable polymer coating loaded with the functional substances, and introducing active groups to the surface of the degradable polymer coating loaded with the functional substances; and then the functional substances are grafted through active groups. The polyetheretherketone composite implant is applied to preparation of a medicine for treating bone defects. According to the polyetheretherketone composite implant prepared by the invention, the excellent mechanical property of the substrate polyetheretherketone is maintained, and the immunocompetence and the osteogenic activity of the surface are also increased.

Description

technical field [0001] The invention belongs to the technical field of biomedical polymer materials, and relates to a polyether ether ketone composite implant with bone immune regulation function and its preparation method and application. Background technique [0002] Bone defect is a common clinical disease, and implanting filling materials is a common way to treat bone defect. The performance requirements for traditional bone implant materials include: excellent physical and chemical properties, such as good corrosion resistance, not easy to wear on the surface, and non-toxic effects of wear debris on the body; mechanical properties that match bone tissue, and good biological properties such as histocompatibility. With the development of implant materials and the further understanding of the interaction between implant materials and the human body, especially the in-depth research on the interaction between implants and the immune system, it has been shown that the early...

AI Technical Summary

Problems solved by technology

Modified by blending with active substances, the change of its mechanical properties often leads to a mismatch with the adjacent bone tissue, which affects the osteogenesis effect; the surface of PEEK is constructed with calcium phosphate or hydroxyapatite coating, which can improve its surface Bioactive, but the prepared coating has limited bond strength to the PEEK surface, peeling off may occur, the hydroxyapatite layer on the substrate is easily broken, and particle wear debris may be generated, which can alter the immune response , secrete inflammatory factors and lead to pathological bone resorption

Grafting BMP-2 by wet chemical method can improve the osteogenic performance, but the reaction generates a series of oxygen-containing groups on the surface, which increases the uncertainty of subsequent experiments, is not conducive to the directional immobilization of proteins, and the reaction is not precise enough and the reaction repeatability is poor. , the experimental results are highly random

Plasma immersion ion implantation builds a titanium dioxide or diamond-like coating on the surface of PEEK, which can increase the surface roughness, chemical modification, and combine with other biologically active particles; after sulfonating the PEEK surface, plasma implants zinc ions to increase the surface roughness degree and osteoconductivity, but the performance of the above-mentioned coatings or factors attached to the surface is single, and the influence of inflammation on osteogenesis after material implantation is not considered, which may lead to inconsistent results in vivo and in vitro, and implantation failure

[0005] In summary, in view of the lack of immune activity and osteogenic activity on the surface of PEEK materials, and poor osseointegration properties, it is of great application value to invent a PEEK composite implant with bone immune regulation function on the existing basis.

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