Application of supported catalyst in continuous preparation of penicillin sulfoxide ester

Abstract

The invention belongs to the technical field of chemistry and chemical engineering. The invention specifically relates to an application of a supported catalyst in continuous preparation of penicillin sulfoxide ester. A carrier of the supported catalyst is an ordered mesoporous material SBA-15, an active component of the supported catalyst is a metal salt, and the mass of the active component metal salt is 1-10% of the mass of the ordered mesoporous material SBA-15. Under the action of a supported catalyst, hydrogen peroxide and penicillin G potassium ester are subjected to a continuous flow oxidation reaction, an oxidation reaction solution is subjected to a continuous flow quenching reaction with a sodium hydrogen sulfite aqueous solution, and a quenching reaction solution is subjected to post-treatment to obtain the penicillin sulfoxide ester. The catalyst provided by the invention has the advantages of simple preparation, high catalytic efficiency, high selectivity and the like, and can be recycled after simple activation. By adopting the supported catalyst disclosed by the invention, the reaction conversion rate of penicillin sulfoxide ester preparation can reach 99.5%, the selectivity can reach 100%, the separation yield can reach 95.9%, and the content can reach 99.3%.

Description

technical field [0001] The invention belongs to the technical field of chemistry and chemical engineering. Specifically, it is the application of a supported catalyst in the continuous preparation of penicillin sulfoxide ester. Background technique [0002] Cephalosporin antibiotics have the advantages of strong selectivity to bacteria, low toxicity to human body, broad-spectrum antibacterial, strong antibacterial effect, and less allergic reactions than penicillins, and are widely used. As an important intermediate in the synthesis of cephalosporin antibiotics, penicillin sulfoxide (GESO) has a wide range of applications and broad market prospects. There are currently four methods for the synthesis of penicillin sulfoxide (GESO) reported in the literature: m-chloroperoxybenzoic acid oxidation, peracetic acid oxidation, oxygen catalytic oxidation, and hydrogen peroxide oxidation. In 1963, Eli Lilly and Company of the United States converted penicillin skeleton to cephalosp...

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Problems solved by technology

[0003] In the prior art, there are mainly two methods for synthesizing penicillin sulfoxide ester with penicillin G potassium as a raw material. The first method uses about 15% peracetic acid as an oxidizing agent to oxidize. In the post-treatment process of this method, a large amount of alkali needs to be used to neutralize a large amount of Acetic acid, a large amount of sodium bisulfite quenches excess peracetic acid, so a large amount of industrial wastewater and waste salt are produced, which is not conducive to environmental protection and increases production costs

The second method uses vanadium pentoxide or sodium tungstate catalyst and hydrogen peroxide as the oxidant to oxidize. The catalyst metabolites are not easy to remove, which affects product quality. At the same time, these metal catalysts cannot be recycled, resulting in waste of resources.

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