Rare earth-hydroxyapatite composite biologically active film and preparation method thereof

A technology of hydroxyapatite and biological activity, which is applied in medical science and prostheses, etc., can solve the problems that the overall content of the film is difficult to control, affects the performance of the matrix material, and weakens the biological activity of the material, so as to achieve faster postoperative healing and good biological The effect of activity and easy promotion and application

Inactive Publication Date: 2007-03-14
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, the plasma spraying method uses hydroxyapatite powder, which is melted by high-temperature plasma to make the particles adhere to the substrate. Since the particles are easily volatilized after being heated at high temperature, the composition of the formed film is difficult to control.
The ion beam sputtering method is to prepare hydroxyapatite by ion beam sputtering, and the overall content of the film is difficult to control
Although the sol-gel method is easy to control the chemical composition and microstructure of the film, it requires post-treatment of high temperature annealing, which affects the properties of the matrix material
The micro-arc oxidation composite process generally has unfavorable factors such as increasing the complexity of the process and weakening the adhesion of the film layer; for example, micro-arc oxidation combined with hydrothermal treatment can transform and precipitate HA, but the bonding strength of the film layer is reduced by 40%; electrophoretic deposition uses electric field The effect makes HA deposited on the metal surface, but due to the loose combination, subsequent sintering treatment is required, which not only reduces the adhesion of the film layer, but also weakens the biological activity of the material during the sintering process

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Use distilled water to prepare a solution containing 0.01 mol / L of sodium hexametaphosphate, 0.01 mol / L of sodium phosphate, 0.3 mol / L of calcium acetate, and 0.001 mol / L of lanthanum acetate. With titanium as the anode and stainless steel or titanium as the cathode, DC power is used for micro-arc oxidation. The voltage is 300-500V; keep the electrolyte temperature not higher than 50°C. The micro-arc oxidation was 5 min, and a porous layer with a thickness of about 23 μm was formed on the titanium surface; X-ray diffraction analysis showed that the film layer was mainly composed of hydroxyapatite, and EDX showed that the La content in the film layer was 0.4%, and the bonding strength of the film layer was 43MPa, with good biological activity.

Embodiment 2

[0025] Use distilled water to prepare a solution containing 0.15 mol / L of sodium β-glycerophosphate, 0.2 mol / L of calcium chloride, and 0.003 mol / L of cerium acetate. Use titanium alloy sheet as anode, stainless steel or titanium as cathode, and use DC power supply for micro-arc oxidation. The voltage is 200-400V; keep the electrolyte temperature not higher than 50°C. The micro-arc oxidation was 30min, and a porous layer with a thickness of about 29 μm was formed on the surface of the titanium alloy; X-ray diffraction analysis showed that the film was mainly composed of hydroxyapatite, and EDX showed that the Ce content in the film was 0.9%, and the bonding strength of the film was It is 43MPa and has good biological activity.

Embodiment 3

[0027] Use distilled water to prepare a solution containing 0.02 mol / L of sodium dihydrogen phosphate, 0.2 mol / L of calcium nitrate, and 0.01 mol / L of lanthanum nitrate. The titanium alloy sheet is used as the anode, and the stainless steel or titanium is used as the cathode, and a DC pulse power supply is used for micro-arc oxidation. The voltage is 250-450V, the frequency is 300Hz, and the duty ratio is 55%; the electrolyte temperature is kept at 30-50°C. The oxidation deposition time is 60 minutes; a porous layer with a thickness of about 26 μm is formed on the surface of the titanium alloy; X-ray diffraction analysis shows that the film layer is mainly composed of hydroxyapatite, and EDX shows that the rare earth La content in the film layer is 1.7%. The strength is 36MPa and has good biological activity.

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Abstract

The invention relates to the means of active biological film on the surface of metal materials, especially the titanium radicel rare earth hydroxyapatite complex active biological film and the process for the manufacture. The differential arc oxidation technology is used in the method, the complex active biological film is generated in the surface of titanium and titanium alloy, a electrolyte solution with phosphate radical ion, calcium ion and rare earth ion is supplied; the titanium and titanium alloy is the anode and the rustless steel or the titanium is the cathode, the direct current power supply or the direct current impulsing power source is applied to differential arc oxygenize the titanium and titanium alloy; the oxidate deposit time is 3-60min; the temperature of electrolyte is not above 50DEG C. The film produced by the method which has perfect bioactivity, high conjugation, and stable chemical property can be the alternate material of several parts with heavy load to accelerate the postoperative healing, such as femur, hip joint and teeth root.

Description

technical field [0001] The invention relates to a method for preparing a bioactive film layer on the surface of a medical metal material, in particular to a titanium-based rare earth-hydroxyapatite composite bioactive film layer used for femurs, hip joints and tooth roots and a preparation method thereof. Background technique [0002] In recent years, the development and application of various biomedical materials have developed rapidly, among which metal materials were the first to be used. Metal biomaterials generally have high strength and toughness, and are suitable for hard tissue repair and fixation. Commonly used metallic biomaterials include cobalt injection. However, due to the surface hardness of titanium and titanium alloys, low-base alloys, tantalum, titanium and titanium alloys, etc., among them, titanium and its alloys have excellent corrosion resistance, high specific strength, good biocompatibility and are suitable for implantation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/54A61L27/56A61L27/58
Inventor 王迎军宁成云黄勇南开辉
Owner SOUTH CHINA UNIV OF TECH
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