Gene regulatory peptides

a technology of gene regulation and peptides, applied in the field of biotechnology, can solve the problems of slow progress in determining exactly how to achieve nuclear transcriptional activation of a specific and limited set of genes, and it is difficult to use peptides in experiments
US20050214943A1Inactive Publication Date: 2005-09-29BIOTEMPT
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Patent Information

Authority / Receiving Office
US · United States
Current Assignee / Owner
BIOTEMPT
Publication Date
2005-09-29
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to the modulation of gene expression in a cell, also called gene control, in particular in relation to the treatment of a variety of diseases. The invention provides a method for modulating expression of a gene in a cell comprising providing the cell with a signaling molecule comprising a peptide or functional analogue thereof. Furthermore, the invention provides a method for identifying or obtaining a signaling molecule comprising a peptide or functional derivative or analogue thereof capable of modulating expression of a gene in a cell comprising providing the cell with a peptide or derivative or analogue thereof and determining the activity and / or nuclear translocation of a gene transcription factor.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of PCT International Application Number PCT / NL02 / 00639, filed Oct. 4, 2002, and published in English as International Publication Number WO 03 / 029292 A2 on Apr. 10, 2003, which claimed continuation-in-part status from U.S. patent application Ser. No. 10 / 028,075, filed Dec. 21, 2001, the contents of all of which are incorporated herein by this reference.BACKGROUND OF THE INVENTION

[0002] This invention relates generally to biotechnology, and more particularly to gene regulatory peptides and methods of their use.

[0003] Gene control is generally thought to occur at four levels: 1) transcription (either initiation or termination), 2) processing of primary transcripts, 3) stabilization or destabilization of mRNAs, and 4) mRNA translation. The primary function of gene control in cells is to adjust the enzymatic machinery of the cell to its nutritional, chemical and physical environment.

[0004] It is general...

Claims

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