The present invention relates to a four-element connection number four-based symptom-oriented medicine use evaluation and prediction method and system. The method includes the following steps that: S1, symptom items are established through observation, listening, interrogation and pulse-taking in traditional Chinese traditional Chinese medicine; S2, curative effect evaluation is performed on the symptom items in the S1; step S3, the curative effect four-element connection number mu(gt) of the items of observation, listening, interrogation and pulse-taking is obtained, wherein the mu(gt) can becalculated according to an equation that mu(gt)=at+bti+ctj+dtk, wherein t is equal to 1, 2, ..., 16; S4, the third-order all-partial-connection numbers of the curative effect four-element connectionnumber mu(gt) are calculated, wherein the third-order all-partial-connection numbers can be calculated according to an equation described in the descriptions of the invention, and the third-order all-partial-connection numbers are sequenced according to a large-to-small order; S5, the ratio Eta of the numbers of people, which can be calculated according to an equation that Eta=the total number ofeffectively cured people/the number of invalidly cured people is sequenced according to a large-to-small order; and S6, the sequential number of the value of Eta of the same item is contrasted with the from-large-to-small sequential numbers of the third-order all-partial-connection numbers of the item. With the method and system adopted, medicines can be increased and decreased correctly accordingto symptoms, and the improvement of the curative effect of the traditional Chinese medicine can be facilitated; and the set pair analysis-based four-element connection number can be used for quantitative research of relationships between symptom-oriented medicine increase and decrease and curative effects and can play a role of evaluation and prediction.