The invention discloses an Internet of Things communication system, gateway equipment and method based on a star topology. The system comprises a cloud server used for communicating with the gateway equipment, informing the gateway equipment of unique identifier information corresponding to each label which needs to be managed by the gateway equipment, and receiving label data of each label collected by the gateway equipment; the gateway equipment used for carrying out communication handshake with each label after obtaining an unique identifier of each label, using a time-division multiplexing mechanism to collect the label data of each label, and transmitting the collected label data to the cloud server; and a plurality of labels, which carry out data transmission with the gateway equipment according to the time-division multiplexing mechanism. The Internet of Things communication system based on the star topology provided by the invention can achieve a simple star Internet of Things topology with fewer resources, and ensure that the data transmission between the gateway equipment and each label is fast and stable.