An antiknock chemical additive for lead-free gasoline comprises the raw materials in parts by weight: 30-40 parts of industrial ethanol, 10-20 parts of industrial methanol, 5-10 parts of ferrocene, 2-10 parts of monomethyl aniline, 5-10 parts of isobutyl acetate, 20-30 parts of methyl tertiary butyl ether, and 10-15 parts of xylene. The addition amount of the antiknock chemical additive in the lead-free gasoline is 0.2-1.0%. The gasoline octane number can be increased by 20-40 units, and the antiknock property and the dynamic property of the gasoline are enhanced. The antiknock chemical additive has the advantages of easily obtained raw materials, low cost, simple process, and easy popularization; the antiknock chemical additive has obvious using effect, significantly increases the octane number, improves oil product chemical properties, has a catalytic combustion function, can allow mixed gas to be fully burnt, improves the oxidation speed, thereby reducing knocking occurrence and having good speed increasing performance; and emissions of CO, hydrocarbons, NOx and solid particles in exhaust gas are greatly reduced, environmental pollution is reduced, moreover, the lead content is extremely low, and economic benefits and social benefits are substantial.