The invention discloses a fatigue driving prevention system. The system comprises a vehicle-mounted computer, a face acquisition camera, an electronic control unit (ECU), a voice module, a wireless module and a customer service terminal, and is characterized in that the face acquisition camera is connected with the vehicle-mounted computer, and the ECU is connected with the vehicle-mounted computer; the voice module is connected with the vehicle-mounted computer, and the vehicle-mounted computer is connected with the customer service terminal through the wireless module. The head and the faceinformation of a driver are recognized and judged, and can be directly confirmed through voice responses, and finally a plurality of reminding modes are set to supervise the driver. Fatigue driving judgment is performed only on the basis of the physiological characteristic, namely the facial expression, of the driver, so that the process is simplified; the state of the driver is judged through integral information of the eyes and the head, and the voice response link is added, so that the accuracy of judging the driving state of the driver is fully guaranteed; a plurality of urging modes are set for the driver to select, so that the supervision efficiency of the driver is improved, and the driving safety of a driver is guaranteed.