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Injection composition of fat milk, amino acid and glucose packed with three-cavity bag and preparing method thereof

A technology of glucose injection and fat emulsion, which is applied to the types of packaging items, special packaging items, packaging, etc., which can solve the problems of easy blockage of capillaries, construction of aseptic preparation rooms, high maintenance costs, and contamination of microorganisms, so as to reduce the risk of transfusion Effects of heat source reaction, avoidance of microbial and particulate contamination of products

Active Publication Date: 2007-08-15
费森尤斯卡比华瑞制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, even with aseptic operating conditions, the probability of contaminating microorganisms is more than one in a thousand
In addition, the construction and maintenance costs of aseptic preparation rooms are quite high, which can be afforded by non-small and medium-sized hospitals and economically underdeveloped areas, which largely hinders the promotion of mixed infusion methods
Another disadvantage of this mixing method is that multiple punctures of the rubber plug will inevitably produce a large number of rubber plug particles, which will easily block the capillaries after entering the blood, causing microcirculation embolism

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] Step one, bag making.

[0069] Take the plastic film for the inner bag, press it on the bag making hot press and connect the filling port. Take the plastic film for the outer bag, press it on the bag making heat press, and leave one side open.

[0070] Step two, dosing. Fat emulsion injection, compound amino acid injection and glucose injection were prepared on different preparation equipment.

[0071] 1) Preparation of fat emulsion injection

[0072] Take 200 grams of purified soybean oil, refined lecithin: 12 grams, anhydrous glycerin: 22 grams, sodium hydroxide: appropriate amount, water for injection: 750 grams.

[0073] Heat 200 grams of soybean oil to about 80°C, add 12 grams of refined lecithin under strong stirring, and continue stirring until dissolved, which is the oil phase.

[0074] Add 22 grams of anhydrous glycerin to 750 grams of water for injection, stir to dissolve, and this is the water phase.

[0075] Slowly add the oil phase to the vigorously st...

Embodiment 2

[0089] Take the following raw materials, L-alanine: 3.45g, glycine: 2.42g, L-arginine: 3.80g, L-aspartic acid: 4.72g, L-glutamic acid: 10.35g, L- Histidine: 2.76g, L-Isoleucine: 4.48g, L-Leucine: 6.10g, L-Lysine Hydrochloride: 5.64g, L-Methionine: 2.18g, L-Phenylalanine: 6.32g, L-proline: 9.32g, L-serine: 8.62g, L-threonine: 3.45g, L-tryptophan: 1.15g, L-tyrosine: 0.575g, L-valine Acid: 4.94g, L-cysteine ​​hydrochloride: 0.167g, calcium chloride dihydrate: 0.423g, magnesium sulfate heptahydrate: 0.426g, potassium chloride: 0.431g, potassium hydroxide: 0.966g, sodium hydroxide : 2.30g, sodium metabisulfite: 0.34g, sodium glycerophosphate: 8.40g, add the above-mentioned raw materials one by one to the water for injection at 60-90°C deoxygenated in advance to prepare 1000ml injection, and stir until dissolved under nitrogen protection. The concentration of dissolved oxygen in the liquid medicine shall not be higher than 100ppm.

[0090] All the other steps, formula are identica...

Embodiment 3

[0092] Step 2, dosing; 2) The compound amino acid injection adopts the following median formula, and the rest are the same as in Example 1.

[0093] Take the following raw materials, L-alanine: 3.00g, glycine: 2.105g, L-arginine: 3.30g, L-aspartic acid: 4.10g, L-glutamic acid: 9.00g, L- Histidine: 2.40g, L-Isoleucine: 3.90g, L-Leucine: 5.30g, L-Lysine Hydrochloride: 4.90g, L-Methionine: 1.90g, L-Phenylalanine: 5.50g, L-proline: 8.10g, L-serine: 7.50g, L-threonine: 3.00g, L-tryptophan: 1.00g, L-tyrosine: 0.500g, L-valine Acid: 4.30g, L-cysteine ​​hydrochloride: 0.145g, calcium chloride dihydrate: 0.372g, magnesium sulfate heptahydrate: 0.370g, potassium chloride: 0.375g, potassium hydroxide: 0.840g, sodium hydroxide : 2.00g, sodium metabisulfite: 0.295g, sodium glycerophosphate: 7.305g, add the above raw materials one by one into the water for injection at 60-90°C deoxygenated in advance to make 1000ml injection, stir until dissolved under nitrogen protection. The concentrati...

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PUM

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Abstract

The invention discloses an injection composition packaged in a three-cavity bag. The three cavities separated by diaphragm are respectively filled with fattiness milk injection, compound amino acid injection, and glucose injection. The using method is crimping each cavity in turns, or divulging the isolating bar in each cavity to mix the injections for venoclysis so as to avoid the venture of microorganism and particulates pollution in traditional mix processing. The mix processing can be carried out under any environmental condition which qualifies the small hospital without aseptic preparation condition to use the nutrition, highly reduce the untoward reaction such as transfusion heater response, sanguis infection, and blood poisoning due to traditional mix processing.

Description

technical field [0001] The invention discloses a composition of fat emulsion, amino acid and glucose injection which is independently packaged in a three-cavity bag and a preparation method of the injection composition. Background technique [0002] Fat, protein and sugar are the three types of basic nutrients that the human body needs the most. When the human gastrointestinal tract is incomplete or unable to absorb enough of the above nutrients, it must be provided in the form of intravenous infusion. Therefore, fat emulsion injection, compound amino acid injection and glucose injection are widely used clinically to provide fat, protein and sugar respectively, which is the so-called parenteral nutrition. From the perspective of nutrient metabolism mechanism, the utilization of these three nutrients is interdependent. Physiologically speaking, when the human body takes in food, it takes in fat, protein and sugar at the same time. Therefore, both theory and practice have pr...

Claims

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Application Information

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IPC IPC(8): A61J1/10A61K9/107A61K31/7004A61K31/4172A61K36/48A61P3/02A61K31/198A61K31/405
Inventor 马涛
Owner 费森尤斯卡比华瑞制药有限公司
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