Medicament microcapsule composite calcium deficiency calcium phosphate bone cement and use, preparation method and application thereof

Abstract

The invention discloses medicament microcapsule composite calcium deficiency calcium phosphate bone cement and the use, the preparation method and the application thereof. The bone cement contains a medicament microcapsule in effective treatment dosage and calcium deficiency calcium phosphate bone cement, wherein the calcium deficiency calcium phosphate bone cement comprises calcium hydrophosphate and tetracalcium phosphate, and a molar ratio of calcium to phosphorus is 1.5. The bone cement is prepared by uniformly mixing the medicament microcapsule and the calcium deficiency calcium phosphate bone cement. When in use, the medicament microcapsule composite calcium deficiency calcium phosphate bone cement is uniformly mixed with curing liquid physiological saline or other saline solutions to be implanted into a body, wherein the liquid-to-solid ratio of the medicament microcapsule composite calcium deficiency calcium phosphate bone cement to the curing liquid is 0.25-2.6g / mL. After the bone cement is implanted into the human body for curing, a medicament is slowly released by a microstructure of curing body and has effects of inflammation elimination and sterilization during bone repair; and a micropore formed after the medicament is slowly released is beneficial to growing new bone tissue, accelerating the degradation of materials and effectively promoting the rapid healing of bones.

Description

technical field

[0001] The invention relates to a drug microcapsule composite calcium-deficiency calcium phosphate bone cement and its use, preparation method and application. Background technique

[0002] Osteomyelitis refers to an inflammatory disease caused by purulent bacteria infecting the bone marrow, bone cortex and periosteum. It may be caused by blood, or caused by trauma or surgical infection, and it may also be caused by furuncle or other lesions into the blood. And up to bone tissue pathogenic. Osteomyelitis can be divided into acute and chronic types according to the development of the disease. Acute osteomyelitis has high fever and local pain at the onset. If the diagnosis is not timely, it will turn into chronic osteomyelitis with ulceration, thick flow, sequestrum or cavity formation. Among them, the two ends of limb bones are most vulnerable, especially the hip joint. Clinically, there are often recurrent cases that have not healed for many years. The tre...