Traditional Chinese medicine compound dispersible tablet used for preventing and treating cardia-cerebrovascular diseases, and preparation method of traditional Chinese medicine compound dispersible tablet
A technology of dispersible tablets and traditional Chinese medicine, which is applied in the fields of cardiovascular system diseases, biochemical equipment and methods, blood diseases, etc., and can solve problems such as easy rebound after drug withdrawal, organ damage, and high cost
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[0014] The preparation method of the dispersible tablet provided by the present invention comprises two steps: A. Raw material preparation: earlier, hawthorn and ginkgo leaves are extracted, concentrated, and spray-dried to obtain the extract; then earthworm and leech are pulverized and sieved; Obtain nattokinase and monascus powder by solid or liquid culture method; B. Tablet production: mix the prepared raw materials with appropriate amount of pharmaceutical excipients in proportion, moisten, compress into tablets, and dry to make dispersible tablets.
[0015] Preferably, in raw material preparation A, the mass ratio of the raw material extracted from Hawthorn to the extract is 10:1, the mass ratio of Ginkgo biloba to the extract is 25:1, the flavonoid glycoside content in the Ginkgo extract is greater than 24%, ginkgo lactone The content is more than 6%, and the ginkgo folic acid is less than 5mg / kg; nattokinase and monascus are respectively cultured in solid, nattokinase is...
Embodiment 1
[0019] Soak 40 grams of soybeans for 10 hours, steam and cool, disperse 2.5 grams of 20,000 FU unit nattokinase in it and mix well, cultivate at 28°C for about a week, and when the soybeans are picked up with chopsticks, put them in a 45°C drying oven Medium-dried, powdered and passed through a 100-mesh sieve to obtain 40 grams of nattokinase powder;
[0020] Soak 10 grams of japonica rice for about 5 hours, after steaming and cooling, evenly sprinkle 1 gram of Monascus on top, and cultivate it at a humidity of 85%, 30°C, pH 4.0, and a cultivation time of about 7 days. When the rice core turns red, Dry and pulverize through a 100-mesh sieve to obtain 10 grams of Monascus powder;
[0021] 200 grams of dried hawthorn slices are first extracted with 95% ethanol, separated to obtain the extract, then extracted with 5 times pure water, concentrated, the extract obtained by alcohol extraction is added to the water extraction concentrate, and auxiliary materials are added to spray dr...
Embodiment 2
[0026] Adopt the method of embodiment S1 to prepare nattokinase powder, Monascus powder, hawthorn extract, ginkgo leaf extract, earthworm protein powder, leech powder to obtain described dispersible tablet S2, the difference is: the nattokinase powder 40%, Hawthorn Extract 20%, Dilong Protein 10%, Monascus 10%, Ginkgo Biloba Extract 10%, Leech 5%, Carboxymethyl Starch Sodium 5%, after mixing evenly, the dispersion of this example was prepared by tableting Slice S2.
[0027] Adopt embodiment S1, S2 dispersible tablet through animal modeling test, has following function:
[0028] (1) Lipid reduction: There were significant differences in total cholesterol, triglycerides, low-density lipoprotein and apolipoprotein A;
[0029] (2) Dissolving thrombus: After feeding rats with 0.1% dispersible tablets of animal weight for 60 consecutive days, the area of thrombosis plaque in blood vessels was dissolved to more than 70%;
[0030] (3) Anti-aging: After measuring the aging physiolo...
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