Antimicrobial preservative compositions for personal care products

a technology of antimicrobial and preservative compositions, which is applied in the direction of biocide, peptide/protein ingredients, hair cosmetics, etc., can solve the problems of difficult to protect personal care products from microbial contamination, high toxicity of chloroxylenol to mammals, and difficult to achieve antimicrobial activity, antibacterial effect, and antibacterial

Inactive Publication Date: 2013-04-25
GALAXY SURFACTANTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0023]There have been some attempts to create synergistic blends avoiding parabens and formaldehyde donors have been reported. For instance, in 2008, Ellen Rozsa et al. reported a synergistic preservative system having an oil-miscible glycol and an enzymatic composition (U.S. Pat. No. 226,568, 2008). The synergistic preservative system of t...

Problems solved by technology

Preservation of personal care products from microbial contamination has become a difficult task since the available approved antimicrobials are very few and those which have good antimicrobial activity are quite toxic.
Chloroxylenol is significantly toxic to mammals and is a skin irritant with quite allergic properties.
However, during 1998 to 2004 a few scientific publications implicated parabens in endocrine disrupting estrogenic activity and some other deleterious effects on reproductive systems in various test methods.
However, this clean chit does not seem to be adequate to mitigate the grave concern about the usage of parabens as preservatives.
Due to the paucity of effective and well-accepted antimicrobials, the industry is forced to continue with the using formaldehyde donors like DMDM hydantoin, imidazolidinyl urea, and diazolidinyl urea.
This is a big disadvantage for sunscreen formulations.
Quaternary ammonium antimicrobials: The third category of the quaternary ammonium compounds (examples are cetyl pyridinium chloride, benzethonium chloride, benzalkonium chloride, polyaminopropyl biguanide), has been of limited use for personal care industry due to specific incompatibilities with other cosmetic ingredients.
It is common knowledge that like phenolic compounds, the halogenated organic molecules exhibit significant levels of toxic effects.
For example, IPBC has risk of thyroid hormonal disturbances due to its iodine content.
But the toxicity of such powerful anti-microbials is extremely high and hence cosmetic formulators do not prefer to use this kind of powerful antimicrobial in the cosmetics that remain on human skin for a long time.
So far there is very little success with the search of a new safe ideal molecule and all the major manufacturers of antimicrobial preservatives for cosmetics continue to manufacture and sell preservative blends with either parabens or with formaldehyde donors.
Preserving personal care products from microbial degradation is quite challenging.
Thus, the requirement for the preservation of the personal care products is indeed quite challenging.
This is further compounde...

Method used

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  • Antimicrobial preservative compositions for personal care products
  • Antimicrobial preservative compositions for personal care products
  • Antimicrobial preservative compositions for personal care products

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0068]Phenoxy ethanol was obtained from Galaxy Surfactants Ltd, Mumbai, India. 2-Ethyl hexyl glycerol (3-(2-ethyl hexyl) oxy 1, 2-propanediol, trade name Sensiva SC-50) was procured from Schulke and Mayr, Germany. Undecylenic acid and octanoic acids were obtained from VVF Ltd, India. All other chemicals were purchased from Aldrich.

[0069]Synthesis of surfactants: N-undecylenoyl monoethanol amide, N-octanoyl glycine, and N-octanoyl monoethanol amide were synthesized in according to the procedures given below.

Preparation of N-Undecylenoyl Monoethanol Amide (MEA Amide of Undecylenic Acid)

[0070]A mixture of undecylenic acid (500 g, 2.71 mol) and monoethanol amine (166 g, 2.71 mol) is stirred under nitrogen blanket in pressure vessel at 140° C. for 4 hr and then the temperature is raised to 165° C. for additional one hour. At this stage, acid value is normally found to be around 10° C. or less. Cool the reaction mass to 60° C. and the molten mass are converted into off white flakes (610 ...

example 2

[0073]Preparation of Preservative Blends:

[0074]General procedure for making the Preservative Blends: A mixture of components [A], [B] and [C] were stirred in the desired ratio of weight % under nitrogen blanket at 40° C. till a clear solution was obtained. It was then cooled to room temperature.

[0075]Preservative Blend No 1:

[0076][A] N-decylenic acid MEA amide: 10%

[0077][B] N-octanoyl glycine: 10%

[0078][C] 2-phenoxy ethanol: 80%

[0079]Preservative Blend No 2:

[0080][A] N-decylenic acid MEA amide: 10%

[0081][B] N-octanoyl monoethanol amide: 10%

[0082][C] 2-phenoxy ethanol: 80%

[0083]Preservative Blend No 3:

[0084][A] N-decylenic acid MEA amide: 15%

[0085][B] N-octanoyl glycine: 15%

[0086][C] 2-phenoxy ethanol: 70%

[0087]Preservative Blend No 4:

[0088][A] N-undecylenic acid MEA amide: 4%

[0089][B] N-octanoyl monoethanol amide: 4%

[0090][C] 2-Phenoxy ethanol: 92%

[0091]Preservative Blend No 5:

[0092][A] N-undecylenic acid MEA amide: 25%

[0093][B] N-octanoyl monoethanol amide: 25%

[0094][C] 2-Phenoxy e...

example 3

[0101]The minimum inhibitory concentration of individual cosmetic ingredients against different microorganism is shown in table 1.

TABLE IMINIMUM INHIBITORY CONCENTRATION OF INDIVIDUALCOSMETIC INGREDIENTS IN PPMOctanoylPhenoxyOctanoylUndecylenoylMEAOrganismethanolGlycineMEA amideamideStaphylococcus85003000>10000>10000aureus ATCC6538S.Pseudomonas40003000>10000>10000aeruginosa Immunotype IVEscherichia coli60003000>10000>10000ATCC 10142Bacillus subtilis40003000>10000>10000ATCC 9372Malassezia furfur40003000>10000>10000MTCC 1374Aspergillus niger90004000>10000>10000Propionibacterium40003000>10000>10000acnes MTCC 1951Candida albicans60004000>10000>10000ATCC 10231

[0102]The surfactant undecelenoyl MEA amide (Formula I, wherein M=NH—CH2CH2—OH), the component [A] is reported to have antifungal activity (Istvan Laczko, HU 9800933 A2), but the activity is too weak to be used as a preservative as shown in Table I, let alone the broad spectrum of activity. The said compound is not reported to posse...

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Abstract

A personal product antimicrobial preservative composition for preservation of topical personal care formulations is provided comprising [A] one or more undecylenic acid derivatives depicted by Formula (I),
[B] one or more octanoic acid derivatives depicted by Formula (II),
and [C] 2-phenoxy ethanol or 2-ethyl hexyl glyceryl ether or mixture of these two ‘liquid alcohol ethers’; wherein, each of the two components [A] and [B] is present in the range of 5 to 20% by weight and together [A] and [B] constitute 10 to 30% by weight and the ‘liquid alcohol ether’, component [C], is present 70 to 90% by weight of the total preservative composition. A method for preserving personal care product from microbial attack is provided containing an aqueous phase comprising three component composition from about 0.5 to 2.5% by weight of the total personal care formulation.

Description

FIELD OF THE INVENTION[0001]The present invention relates to the preservation of personal care formulations with synergistic blends of three types of ingredients that offer a broad spectrum of activity against the microbes namely, an undecylenic acid derivative of Formula (I), an octanoic acid component of Formula (II) and a liquid alcohol ether, 2-phenoxy ethanol or 2-ethyl hexyl glyceryl ether or blend of the two. Further, the invention relates to the use of the combinations of three types of cosmetic ingredients.BACKGROUND AND PRIOR ART OF THE INVENTION[0002]Preservation of personal care products from microbial contamination has become a difficult task since the available approved antimicrobials are very few and those which have good antimicrobial activity are quite toxic. Consumers want products meant for topical applications to be free from toxic antimicrobials that are used as preservatives. This situation is partly addressed by exploiting the synergy between disparate of anti...

Claims

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Application Information

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IPC IPC(8): A61K8/92A01N37/20A61Q19/00A61Q5/02A61Q17/04A01N37/46A01P1/00
CPCA61K8/33A01N37/20A61K8/42A61K8/44A61Q5/02A61Q9/02A61Q17/005A61Q17/04A61Q19/00A61Q19/10A61K2800/5922A61K8/34A01N31/14A61K8/345A01N37/46A01N37/44A01N2300/00
Inventor KOSHTI, NIRMALRATNAPARKHE, SHRADDHA KIRANMALI, DEVYANI ASHOKSAWANT, BHAGYESHVAIDYA, POOJA DINKAR
Owner GALAXY SURFACTANTS
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