40 results about "Heart transplants" patented technology

A highly purified and heat stable cross-linked nonpolymeric tetrameric hemoglobin suitable for use in mammals without causing renal injury and vasoconstriction is provided. A high temperature and short time (HTST) heat processing step is performed to remove undesired dimeric form of hemoglobin, uncross-linked tetrameric hemoglobin, and plasma protein impurities effectively. Addition of N-acetyl cysteine after heat treatment and optionally before heat treatment maintains a low level of met-hemoglobin. The heat stable cross-linked tetrameric hemoglobin can improve and prolong oxygenation in normal and hypoxic tissue. In another aspect, the product is used in the treatment of various types of cancer such as leukemia, colorectal cancer, lung cancer, breast cancer, liver cancer, nasopharyngeal carcinoma and esophageal cancer. Another application is heart preservation in situations where there is a lack of oxygen supply in vivo, such as in heart transplant or oxygen-deprived heart.

A percutaneous implanted device for temporarily sustaining a patient awaiting a heart transplant. The device includes a radially expandable stent mounted upon the balloon section of a balloon catheter. A venous biological valve is mounted at each end of the stent and an inflatable annular-shaped diaphragm is secured to the stent between the valves, which permit the flow of blood in one direction and prevent the flow of blood in the opposite direction. The diaphragm is attached to a pump which inflates the diaphragm after the stent is implanted in a blood vessel in relation to the heart's rhythm to assist the heart in moving blood through the patient's circulatory system.

Gene expression is measured in a sample of peripheral blood mononuclear cells (PBMCs) obtained from a subject and used to predict organ function recovery. A Function Recovery Potential (FRP) score is assigned to a sample that reflects the measured expression level of the genes identified herein in a direction associated with recovery from organ failure. Treatment of the subject with optimal medical management (OMM) and / or palliative care (PC) is advised when the FRP score is lower than the reference value, and referring the subject for treatment with therapies including—but not limited to—mechanical circulatory support (MCS) surgery, heart transplant (HTx) surgery, or other intervention for advanced heart failure is advised when the FRP score is greater than the reference value. A method for developing an FRP scoring algorithm that predicts a subject's ability to recover from medical intervention for organ failure is also described.

Improved methods for heart transplant are described. The methods utilize an allograft comprising a layer of amnion to improve the performance and reduce complications of the heart transplant surgery and the allograft has a pre-made size and shape suitable for the application.

The present disclosure provides methods involving use of BIN1 expression levels, in heart tissue, in evaluating the risk of a poor outcome in a patient diagnosed with congestive heart failure. The methods finds use in evaluating patients who are heart transplant candidates as well as in assessing therapy options and efficacy of treatment in congestive heart failure patients.

The invention discloses a new use of an aryl urea derivative in the preparation of a medicine for treating transplant rejection. The aryl urea derivative is 1-(3-(trifluoromethyl)-4-chloro-phenyl)-3-(3-(6-(1-methyl-4-pyrazolyl)-4-oxypyrimidine)-6-fluorine-phenyl) urea. The compound disclosed by the invention can obviously relieve the rejection reaction of the body to transplanted organs and improve the functions of transplanted organs and can be used for preparing the medicine for preventing and curing organ transplant rejection reaction, in particular the medicine for preventing immune rejection reaction after kidney, liver or heart transplant.

The invention relates to a mycophenolic acid derivative as shown in a formula V and a pharmaceutically acceptable salt thereof, wherein L is -O-R2, -QCOOR2 or -QCONR2R3, Q is alkylene of C1 to C10 or alkenylene of C1 to C6, and -O-R1, or -O-*M+. The invention further relates to a pharmaceutical composition containing the mycophenolic acid derivative, the pharmaceutically acceptable salt and pharmaceutical adjuvants, a preparation method of the mycophenolic acid derivative and the pharmaceutically acceptable salt, and an application of the mycophenolic acid derivative and the pharmaceutically acceptable salt in immunosuppressant drugs, especially in preparing drugs for treating organ transplants such as skin transplant, liver transplant and heart transplant, and autoimmune diseases such as psoriasis, rheumatoid arthritis, systemic lupus erythematosus, vasculitis, lupus nephritis, IgA nephritis, glomerulus nephritis, etc.

The invention discloses a new use of an aryl urea derivative in the preparation of a medicine for treating transplant rejection. The aryl urea derivative is 1-(3-(trifluoromethyl)-4-chloro-phenyl)-3-(3-(6-(1-methyl-4-pyrazolyl)-4-oxypyrimidine)-phenyl) urea. The compound disclosed by the invention can obviously relieve the rejection reaction of the body to transplanted organs and improve the functions of transplanted organs and can be used for preparing the medicine for preventing and curing organ transplant rejection reaction, in particular the medicine for preventing immune rejection reaction after kidney, liver or heart transplant.

The invention provides targeting micro-bubbles which comprise a casing and micro-bubbles, wherein the micro-bubbles consist of gases wrapped with the casing; the casing is connected with a C4d antibody or a C3d antibody. The targeting micro-bubbles are adopted as a contrast agent for ultrasonic developing upon C4d or C3d deposited in kidney and heart transplant, and through qualitative and quantitative analysis, AMR (Antibody-Mediated Rejection) can be accurately diagnosed.

The invention discloses a miRNA-182 inhibitor.The sequence of the inhibitor is as follows: 5'-CGGUGUGAGUUCUACCAUUGCCAAA-3', wherein each nucleotide is modified by 2'-OMe, first two basic groups of the 5' end and first 4 basic groups of the 3' end are modified by phosphorus sulfuryl bonds, and the 3' end is modified with a cholesterol group.The miRNA-182 inhibitor can be used for preparing a drug for preventing and treating immunological rejection of heart transplantation.The miRNA-182 specific targeting inhibitor can be beneficial for reducing an allogeneic immune response and prolonging the graft survival time by inhibiting expression of miRNA-182 in a targeted mode after heart transplant surgery and can supply a basis to preparation of the drug for preventing heart graft dysfunction and protecting the heart graft functions.

The invention specifically discloses applications of stem cells in a heart transplantation model. The process comprises the following steps: S1, culturing cardiosphere-derived cells (CDCs); S2, preparing a platelet-rich fibrin scaffold; S3, observing the platelet-rich fibrin scaffold; and S4, carrying out combined transplantation of the cardiosphere-derived cells and the platelet-rich fibrin scaffold. The result shows that the cardiac function after myocardial infarction can be well corrected after the CDCs are combined in the platelet-rich fibrin scaffold, meanwhile, the platelet-rich fibrinscaffold and the CDCs can realize the mutual promotion effect, after combined transplantation, more vascular endothelial cells and myocardial cells can be regenerated, the blood vessel density at theinfarction part can be increased, more stem cells are gathered to enter the infarction area for achieving the regeneration function, thus the negative cardiac remodeling is reversed, and the cardiac function is improved.

The current invention relates to an implantable device, system, method, and computer readable medium comprising computer executable components for detection of rejection of a cardiac allograft. Acute rejection and chronic rejection are the leading cause of death in heart transplant recipients post transplant. The current invention seeks to address this problem by providing methods, devices, systems and computer readable media comprising computer executable components to monitor the efficacy of immunosuppressant therapy and evaluate the degree of rejection in a cardiac allograft. To provide this functionality, an implantable device comprises sensors which measure physiologic parameters at specified intervals after the transplant procedure. These measured parameters are subsequently compared with baseline parameter data to detect rejection of the cardiac allograft.

The invention relates to a hemolysis-free continuous isolated heart transfer device which comprises a box body and a box cover, a circulating liquid cavity and a heart placing cover are arranged in the box body, the heart placing cover is of a solid net-shaped structure similar to the shape of the heart, two blood vessel penetrating-out connectors are arranged on the heart placing cover, a displacement pump circulating device is arranged in the circulating liquid cavity, a liquid inlet pipe and a liquid outlet pipe are connected to the displacement pump circulating device, the liquid inlet pipe and the liquid outlet pipe are aligned to the two blood vessel penetrating-out connectors respectively, and elastic ribbons are arranged on the blood vessel penetrating-out connectors. In the heart transfer process, the heart can be kept in a circulating state, meanwhile, blood cell damage is effectively reduced, damage to the heart caused by in-vitro transfer is reduced, and the heart transplantation success rate is increased.

The invention is a method for treating a heart failure patient with the steps of measuring the concentration of IGFBP2 in a blood, plasma or urine sample obtained from the heart failure patient and comparing the patient's IGFBP2 level to a threshold value derived from IGFBP2 measured in samples taken from a group of patients with heart failure selected from the group consisting of stage I, stage stage III and stage IV heart failure, according to New York Heart Association (NYHA) classification system. A patient with an IGFBP2 level that exceeds the threshold value is admitted or readmitted to a hospital and treated with at least one treatment selected from the group consisting of administration of a beta-blocker, an angiotensin-converting enzyme inhibitor, an angiotensin receptor blocker, an aldosterone antagonist, an implantable cardiac defibrillator, a cardiac resynchronization therapy, an implantable left ventricular assist device and a heart transplant.

The invention discloses a fixator for a cardiac surgery transplantation operation and a using method thereof, and relates to the technical field of heart transplantation. The fixator comprises a fixator body, side sliding grooves are formed in the two corresponding sides of the fixator body, first sliding blocks are slidably connected into the two side sliding grooves, outer mounting blocks are fixedly mounted on one sides of the two first sliding blocks, first rotating grooves are formed in one sides of the outer mounting blocks, and first rotating connecting columns are rotationally connected into the first rotating grooves. The fixator for the cardiac surgery transplantation operation has the beneficial effects that the two sets of main clamping frames and an auxiliary fixing frame are used, the auxiliary fixing frame can be used for fixing a heart from the lower portion of the heart, the main clamping frames are used for fixing the heart from the two sides of the heart, therefore the heart can be more conveniently fixed, and through a multi-section type rotating mechanism of the auxiliary fixing frame, the fixator can better conform to the surface contour of the heart and is more convenient to use.

The invention relates to the technical field of Fontan postoperative adjuvant treatment apparatus, in particular to a novel auxiliary device for the treatment of Fontan circulatory failure. The novelauxiliary device for the treatment of the Fontan circulatory failure includes a balloon, the balloon is placed at the intersection of pulmonary arteries, superior vena cava and inferior vena cava after Fontan operation; the two ends of the balloon are separately located in the superior vena cava and inferior vena cava; and as the balloon is inflated and deflated, blood in the superior vena cava and the inferior vena cava is squeezed into the pulmonary arteries. Through the way, the balloon is placed at the intersection of the pulmonary arteries, the superior vena cava and the inferior vena cava, through the inflation and deflation of the balloon, the balloon expands and contracts, and then the blood in the superior vena cava and the inferior vena cava is squeezed into the pulmonary arteries. Valves coupled with the balloon are opened and closed simultaneously to prevent the blood from flowing back to the superior vena cava and the inferior vena cava, so that the blood pulsates into thepulmonary arteries to play a role of a part of a right ventricular, so that patients with the Fontan circulatory failure are treated, and strong conditions are provided for later heart transplant operation.

The invention discloses a thoracic cavity opening device and method for a heart transplantation operation, and relates to the technical field of heart transplantation. The thoracic cavity opening device comprises a fixed arm, an adjusting box is fixedly connected to the top of the fixed arm, a moving groove is formed in the bottom of the fixed arm, a fixed plate is fixedly connected to the middle of the top of an inner cavity of the moving groove, and two sides of the fixed plate are respectively and rotatably connected with a screw rod; according to the thoracic cavity opening device for the heart transplantation operation, by arranging a rotating column, the rotating rod and the screw rods, the rotating column drives the rotating rod to rotate when rotating, so that the two screw rods rotate, two moving arms can move at the same time, and the thoracic cavity is opened; and a screw and a threaded groove are arranged, when the opening position of one moving arm needs to be finely adjusted in operation, the screw above the other moving arm is screwed, the bottom end of the screw extends to the inside of the threaded groove, and the bottom end ofthe screw is in threaded connection with the thread groove, so that the other moving arm cannot be rotated, and adjustment is facilitated.

The invention discloses application of a PCSK9 inhibitor in anti-rejection after cardiac transplantation. The PCSK9 inhibitor is alirocumab, a usage mode of the PCSK9 inhibitor is of subcutaneous injection, and the dosage of use is 10mg / kg / week. According to the application of the PCSK9 inhibitor in the anti-rejection after the cardiac transplantation, provided by the invention, compared with that a rejection after cardiac transplantation is treated by purely using an immunosuppressant at present, after combined application of the PCSK9 inhibitor, the alleviation of an immunologic rejection after cardiac transplantation and the prolonging of survival time of a heart transplant are better facilitated. Furthermore, the survival cycle of the transplant can also be effectively prolonged by independently using the PCSK9 inhibitor.

The invention discloses a fixer for cardiac surgery transplantation and a method for using the same, relating to the technical field of heart transplantation, comprising a fixer main body, side sliding grooves are provided on both sides corresponding to the main body of the fixer, and two side sliding grooves The first sliders are slidably connected inside, one side of the two first sliders is fixedly installed with an outer mounting block, one side of the outer mounting block is provided with a first rotating groove, and the inner rotation of the first rotating groove is connected with a second A rotating connecting column, the beneficial effect of the present invention is: the fixer for heart surgery transplantation, by using two sets of main clamping frames and an auxiliary fixing frame, the heart can be fixed from the bottom of the heart by using the auxiliary fixing frame, and The heart can be fixed from both sides of the heart by using the main clamping frame, so that the heart can be fixed more conveniently, and the multi-stage rotating mechanism of the auxiliary fixing frame can better conform to the surface contour of the heart, and the use is more convenient.

The current invention relates to an implantable device, system, method, and computer readable medium comprising computer executable components for detection of rejection of a cardiac allograft. Acute rejection and chronic rejection are the leading cause of death in heart transplant recipients post transplant. The current invention seeks to address this problem by providing methods, devices, systems and computer readable media comprising computer executable components to monitor the efficacy of immunosuppressant therapy and evaluate the degree of rejection in a cardiac allograft. To provide this functionality, an implantable device comprises sensors which measure physiologic parameters at specified intervals after the transplant procedure. These measured parameters are subsequently compared with baseline parameter data to detect rejection of the cardiac allograft.

The invention discloses an electrosurgical knife for heart transplantation and a method for using the same, and relates to the technical field of heart transplantation. Electric knife assembly, the electric knife for heart transplantation, is equipped with the second electromagnet, the first electromagnet and the push button. When the doctor accidentally releases the protective shell when packing up the operation, causing the protective shell to fall, the connecting spring Push the push button to move up, so that the push button drives the detection board to move, so that one side of the detection board is out of contact with the detection end of the trigger switch. At this time, the first electromagnet and the second electromagnet are turned on, so that the first electromagnet and the second electromagnet Mutually repulsive magnetic fields are generated between the two electromagnets, so that the moving plate pushes one end of the protective cover to move out of the protective cover to wrap the working end of the second electrosurgical assembly, thereby protecting doctors and patients.

The invention discloses an auxiliary device for heart transplantation and a method of use thereof, relating to the technical field of heart transplantation, comprising a top mounting plate, the bottom of the top mounting plate is provided with a first sliding groove, and the inside of the first sliding groove is Two first sliding blocks are slidably connected, the bottom of the first sliding block is fixedly installed with a bottom mounting block, and one side of the inner wall of the bottom mounting block is provided with a blood storage cavity, and the bottom of the bottom mounting block is located at the storage A blood vessel is fixedly installed below the blood chamber, and an outer installation box is fixedly installed on the side of the bottom installation block close to the blood chamber: the beneficial effect of the present invention is that the auxiliary device for heart transplantation is installed by using a top-mounted installation structure, it can be installed on the top of the operating room and above the medical bed when in use, so as to avoid occupying the internal space of the operating room as much as possible, and the device on the top can be more convenient for doctors to use and improve the operation efficiency. efficiency.

The invention discloses a surgical retractor for heart transplantation and a method for using the same, and relates to the technical field of medical devices, in particular to a surgical retractor for heart transplantation, including a retractor rod, a retractor box is snapped on the surface of the retractor rod, and the One end of the hook rod is fixedly connected with an adjustment box, and a storage room is opened inside the adjustment box, and a second screw rod is movably sleeved in the inner cavity of the storage room, and a second servo motor is fixedly installed on the top of the adjustment box . The retractor for heart transplantation is used in conjunction with the adjustment box, the second screw rod, the first retractor and the toothed connection block. During the heart transplant operation, first observe the thickness of the skin and fat of the patient's chest cavity, and then start the second The servo motor drives the second screw to rotate, and the meshing transmission between the second screw and the toothed connection block drives the first retractor to move up and down, realizing the function of adjusting the length of the first retractor and improving the stability of the surgical retractor for heart transplantation .

The present disclosure relates to methods of diagnosing acute rejection of a cardiac allograft in a subject using genomic expression profiling, proteomic expression profiling, or both on panels of nucleic acid markers and proteomic markers.

The present invention relates to a pruning and measuring device for the left atrium of a transplanted heart, and a use method of the pruning and measuring device. The pruning and measuring device comprises an elliptical measuring plate, and an operating rod vertically passing through the measuring plate, wherein the edge of the measuring plate is connected with an adjustment airbag, a sealed inflation cavity is formed between the measuring plate and the adjustment airbag, one end of the operating rod penetrates through the adjustment airbag and is connected with a positioning airbag, the otherend of the operating rod is provided with a hand-pinch type airbag, a ventilation groove is arranged in the operating rod, a section, located in the adjustment airbag, of the operating rod is provided with ventilation holes, the hand-pinch airbag, the positioning airbag and the adjustment airbag communicate with each other through the ventilation groove and the ventilation holes, and the hand-pinch airbag is provided with a one-way air inlet valve. The pruning and measuring device is used for pruning the left atrium of a transplanted heart before a heart transplantation operation, and can measure and mark a size of an incision to be pruned and a tissue removal amount according to needs, so that the accurate pruning is ensured, and the operation difficulty is reduced.

The invention discloses a preservation device for heart transplantation and a method of use thereof, relating to the technical field of heart transplantation, comprising a protection box, the top of the protection box is rotatably connected with a cover plate, and the top of the protection box is located below the cover plate A storage chamber is provided. The storage device for heart transplantation is equipped with an air bag, a connecting piece and a moving column. When the operator closes the cover, he pushes the moving column to move down, so that the rack drives the transmission gear to rotate, thereby driving the piston through the transmission mechanism. Move to the direction of the connecting pipe, so that the piston pushes the gas inside the storage cylinder into the airbag through the connecting pipe, so that the airbag expands, so that the airbag pushes the connecting piece to move towards the direction of the storage box, so that the connecting piece pushes the pressure plate to limit the storage box, so that this The device can not only limit the position of the storage box, but when the device is hit, the air bag buffers the force received by the storage box, so that the heart tissue inside the storage box will not be damaged.

The invention discloses a new use of an aryl urea derivative in the preparation of a medicine for treating transplant rejection. The aryl urea derivative is 1-(3-(trifluoromethyl)-4-chloro-phenyl)-3-(3-(6-(1-methyl-4-pyrazolyl)-4-oxypyrimidine)-6-fluorine-phenyl) urea. The compound disclosed by the invention can obviously relieve the rejection reaction of the body to transplanted organs and improve the functions of transplanted organs and can be used for preparing the medicine for preventing and curing organ transplant rejection reaction, in particular the medicine for preventing immune rejection reaction after kidney, liver or heart transplant.

The present invention relates to the field of molecular detection, more specifically, to molecular probes targeting CXCR4. The present invention claims a molecular probe targeting CXCR4, and the molecular probe is a compound having the following sequence, or a pharmaceutically acceptable salt or lipid thereof: cyclic peptide (Arg-Nal-Gly-D-Tyr-Tyr- (N-Me)D-Lys)-R n , wherein, R is selected from the group consisting of a linking group, a chelating agent, a radionuclide, another targeting polypeptide or a monoclonal antibody, a monoclonal antibody fragment, and a small molecule inhibitor; wherein, n represents the number of R, and n=0 -4. The probe has good stability in vitro, can be clearly visualized in acute rejection after tumor and heart transplantation, and has good specificity.

The invention discloses a surgical retractor for heart transplantation and a using method thereof, and relates to the technical field of medical instruments, in particular to a surgical retractor for heart transplantation. Thesurgical retractor comprises a retractor rod, a retractor box is clamped on the surface of the retractor rod, an adjusting box is fixedly connected to one end of the retractor rod, and a storage chamber is formed in the adjusting box. And a second lead screw is movably connected to an inner cavity of the storage chamber in a sleeving mode, and a second servo motor is fixedly mounted at the top of the adjusting box. According to the operation retractor for heart transplantation, through cooperative use of an adjusting box, a second lead screw, a first retractor body and a tooth-shaped connecting block, in the heart transplantation operation process, the thickness of the skin and fat of the thoracic cavity of a patient is observed firstly, and then the second servo motor is started to drive the second lead screw to rotate; and a first retractor is driven to move up and down through meshing transmission of the second lead screw and the tooth-shaped connecting block, the function of adjusting the length of the first retractor is achieved, and the stability of the surgical retractor for heart transplantation is improved.