22 results about "Intra peritoneal" patented technology

A sensor (e.g., an optical sensor) that may be implanted within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a sensor housing, an analyte indicator covering at least a portion of the sensor housing, and one or more compounds containing boronate or boronic acid moieties that reduce degradation of the analyte indicator.

The present invention relates to a protective agent selected from the group consisting of L-glutamine, L-alanyl-L-glutamine, L-glutamyl-L-alanine, L-glutamyl-L-glycine, L-glycyl-L-glutamine, or a mixture thereof, and to a method for preparing the protective agent, the present invention relates to a protective agent for use in the prevention and / or treatment of diseases associated with end-stage nephropathy (ESKD) mediated by liver dysfunction induced by peritoneal dialysis treatment, specifically for the prevention and / or treatment during peritoneal dialysis treatment: (A) liver diseases induced by said peritoneal dialysis treatment and / or (B) diseases associated with ESKD mediated by liver dysfunction induced by said peritoneal dialysis treatment, wherein said protective agent is administered by intraperitoneal administration.

The utility model relates to a puncture hole suturing device for laparoscopic surgery. The device includes a stapling body and a sleeve. The suturing body is used for suturing a puncture hole of a patient. The hollow-cylinder-shaped sleeve is provided with a hollow-cylinder-shaped guide sleeve piece which is fixedly connected with the sleeve in the mode that the axes are not collinear or staggered, so that the guide sleeve piece and the sleeve do not move relative to each other. The front suture section and the guide kit enter the body of a patient through a puncture hole of the patient in a mutually embedded mode. The front suture section can be embedded with the guide kit so as to avoid operation injury before, during and after implantation, suture direction deviation caused by rotation of the suture body can be avoided, operation stability is effectively improved, and the front suture section can be conveniently implanted into an abdominal cavity through a laparoscope puncture hole and sutured from an intraperitoneal line to the subcutaneous direction.

Viruses, bacteria, and parasites frequently cause infections in the gastrointestinal (GI) tract, but traditional vaccination strategies typically elicit little or no mucosal antibody responses. Disclosed herein is a vaccine comprising a nanoemulsion and an immunogen non-covalently conjugated to the surface of the nanoemulsion by an amphiphilic linker, wherein the vaccine is suitable for inducing a mucosal antibody response in the gastrointestinal tract. Also disclosed are methods of using the vaccine to immunize a subject by intraperitoneal administration of an effective amount of the vaccine, alone or with an adjuvant.

Techniques for monitoring intraperitoneal volume (IPV) during a dwell period of a peritoneal dialysis patient include monitoring intraperitoneal pressure (IPP) during the dwell period using a pressure sensor, monitoring the density of the dialysate during the dwell period, and determining a change in IPV based at least on a change in IPP and a change in the density of the dialysate during the dwell period.

A sensor (e.g., an analyte sensor) that may be implanted partially or fully within a living animal (e.g., a human) and may be used to measure an analyte (e.g., glucose or oxygen) in a medium (e.g., interstitial fluid, blood, or intraperitoneal fluid) within the animal. The sensor may include a housing, a first polymer that includes analyte indicator molecules and covers at least a portion of the housing, and a second polymer that forms an interpenetrating network with the first polymer. The second polymer may prevent biological or protein interference of the sensor.

Trocar assemblies and methods of use are described in which trocar assemblies are configured to provide access to an intraperitoneal space through a rectal uterine recess to a surgical tool, optionally including one or more surgical robotic components. The diameter of the surgical tool is optionally 5 mm or greater. In some embodiments, the cannula portion has a lumen sized to provide access to a plurality of surgical tools via a rectal uterine recess while transvaginal access to an intraperitoneal space. In some embodiments, one or two dilators are optionally used to form an incision sized to receive the distal bore of the cannula. The dilator may be sized to form a rectangular hole (optionally beginning with puncturing by a needle having a diameter of 2 mm or less). In some embodiments, the rectangular aperture has a width on the major axis that is at least twice the width on the minor axis.

The present disclosure provides a use of a liposomal suspension comprising transmembrane pH-gradient liposomes, for the treatment of an acute hyperammonemia episode (HAC) associated with inborn errors of metabolism (IEM) in a subject, wherein the treatment comprises intraperitoneally administering the liposomal suspension to the subject and removing a dialysate containing ammonia-loaded liposomes from the subject.

This invention relates to pharmaceutical compositions and methods for treating or preventing autoimmune diseases in patients or subjects in need, said pharmaceutical compositions comprising: a 5-benzylaminosalicylic acid compound represented by chemical formula (I) or a pharmaceutically acceptable salt thereof; and, for example, a pharmaceutically acceptable carrier suitable for oral, intraperitoneal, or intravenous administration. Compositions comprising a 5-benzylaminosalicylic acid compound of chemical formula (I) or a pharmaceutically acceptable salt thereof can be used to treat autoimmune diseases.

The application provides a new crown vaccine carrier and application thereof. Composed of SARS-CoV-2 RBD as an antigen and STING agonist diABZI coupled with yeast beta-glucan particles. Compared with the diABZI-RBD vaccine alone, the GP-diABZI-RBD vaccine shows sustained vaccine release and elicits a more persistent immune response in mice. Intraperitoneal injection of GP-diABZI-RBD in mice can cause significant cellular and humoral immune responses. Using a replicable virus-like particle system based on pseudovirus particles, we determined that this vaccine can effectively induce effective and persistent neutralizing antibodies against the prototype and VOC, respectively. In particular, the prototype RBD antigen provided by the GP-diABZI-RBD vaccine shows a stronger and longer humoral immune response and antiviral protection.

Described herein is a hydrophobic anti-cancer drug encapsulated into poly(alkyl cyanoacrylate) nanoparticles and their use in cancer treatments by intracavitary rout of administration such as intraperitoneal administration.

Disclosed are: a system comprising a gas circulation device capable of circulating hyperthermic gas in the peritoneal cavity and a temperature control device; and a system comprising a drug spray device for effectively spraying a drug in the peritoneal cavity together with gas. The systems of the present invention are used as systems for hyperthermic intraperitoneal chemotherapy and can maximize the anticancer therapy effect by more effectively delivering a small amount of an anticancer drug to cancer cells while maintaining the temperature of gas in the peritoneal cavity at a predetermined temperature.

A method of treating metabolic dysfunction-associated steatotic liver disease in a patient, reducing hepatic fat accumulation in a patient, and / or eliminating hepatic fat in a patient can include administering a therapeutically effective amount of Pam3CysSerLys4 (Pam3CSK4) to the patient in need thereof. The therapeutically effective amount of Pam3CysSerLys4 may be administered via an Intraperitoneal (IP) injection.

A surgical device or a portion of a surgical device places a purse string suture in tissue within a body (e.g., an intraperitoneal space). The surgical device includes or a distal end effector for a surgical device includes a jaw assembly, a staple cartridge, and a suture.

The invention relates to an implantable artificial kidney and a use method thereof, and the implantable artificial kidney comprises an implantable micro pump, a suction tube piece, a percolate conveying tube, a flow sensor, a pressure sensor, a creatinine urea online detection module, a control chip, a battery, a charging induction coil, an in-vitro charger and a mobile phone APP or a computer terminal, and continuous or intermittent micro-suction is performed on the outer side of the peritoneum for 24 hours to form negative pressure of the outer side of the peritoneum to the inner side of the peritoneum, so that liquid, water and solute (including toxins) on the inner side of the peritoneum convect to the outer side of the peritoneum to form percolate, and the percolate is guided into the bladder through the percolate conveying pipe and is discharged out of the body through normal urination of the human body. According to the implantable artificial kidney and the use method thereof, the design is reasonable, a more effective treatment effect is brought to a renal failure patient, the life quality of the patient can be obviously improved, the life cycle of the patient can be prolonged, and the treatment cost of the patient can be reduced.

The present invention relates to a composition for preventing or treating inflammatory diseases induced by an autoimmune response, the composition comprising a peptide or peptide mixture as an active ingredient. More specifically, a composition comprising peptides P1 to P5 or a mixture thereof as an active ingredient can be provided as a therapeutic agent for inflammatory diseases induced by an autoimmune response. This is because, as a result of intraperitoneal injection or external application of peptides P1 to P5 or a mixture thereof to mouse animal models of psoriasis and inflammatory bowel disease (inflammatory diseases induced by an autoimmune response), it was confirmed that skin ulcers and skin inflammation in the mouse model of psoriasis and inflammatory bowel disease were alleviated, and inflammatory symptoms in the model of bowel inflammation were alleviated.

Techniques for monitoring fluid volume during peritoneal analysis include: continuously calculating lower abdominal fluid volume during a dwell time of a peritoneal dialysis treatment based at least on bioimpedance data from electrodes located on the patient's upper thigh; and continuously calculating intraperitoneal volume during a dwell time of a peritoneal dialysis treatment based at least on bioimpedance data from electrodes located on the patient's upper thigh and electrodes located on the patient's torso.

An Umbilical cord derived mesenchymal stem cell (UC-MSC) conditioned media (UC- MSC-CM) composition of the range from 5%-100% possessing immunomodulatory effect inhibiting tumour growth when administered intraperitoneally and intravenously. MSC- CM arrests cell cycle in leukaemia cells (K-562 and HL-60), lung cancer cells (A549 and HOP-62), breast cancer cells (MDA-MB-231 and MCF-7) and cervical cancer cells (HeLa). Elevated levels of IL-6, TIM3 and TIMP2 in MSC-CM confer to its immunomodulatory function by leading to an increase in expression of activation markers, cytotoxic granules, mucosal associated invariant T cells and decreasing the inflammasome pathway activation, consequently decreasing the levels of innate immune inflammasome pathway molecules in treated xenograft tumor tissues. MSC-CM as an adjunct with IL-12 augments cytotoxic potential against cancer cell lines. Tumor inhibition effect of MSC-CM is shown by significant reduction of relative tumor volume which is expressed by fold change of genes involved in various pathways affecting xenograft tumor growth.

Improvements in fluid volume measurement systems are disclosed for a pneumatically actuated diaphragm pump in general, and a peritoneal dialysis cycler using a pump cassette in particular. Pump fluid volume measurements are based on pressure measurements in a pump control chamber and a reference chamber in a two-chamber model, with different sections being modeled using a combination of adiabatic, isothermal and polytropic processes. Real time or instantaneous fluid flow measurements in a pump chamber of the diaphragm pump are also disclosed, in this case using a one-chamber ideal gas model and using a high speed processor to obtain and process pump control chamber pressures during fluid flow into or out of the pump chamber. Improved heater control circuitry is also disclosed, to provide added or redundant safety measures, or to reduce current leakage from a heater element during pulse width modulation control of the heater element. Improvements are also disclosed in an application of negative pressure during a drain phase in peritoneal dialysis therapy, and to control an amount of intraperitoneal fluid accumulation during the therapy. Improvements in efficiency are also disclosed in movement of fluid into and out of a two-pump cassette and a heater bag of the peritoneal dialysis cycler, and in synchronization of operation of two or more pumps in the peritoneal dialysis cycler or other fluid handling devices using a multi-pump arrangement.

The invention discloses an auxiliary purse-string suturing device for peritoneal dialysis catheterization, and relates to the field of peritoneal dialysis catheterization, the auxiliary purse-string suturing device comprises a mounting mechanism, the mounting mechanism comprises a mounting main rod, the surface of the mounting main rod is provided with an adjusting groove, the surface of the adjusting groove is provided with an adjusting mechanism, the adjusting mechanism comprises an adjusting ring and a fixing ring, and the fixing ring is provided with a fixing groove. The adjusting ring and the fixing ring are both sleeved with an adjusting groove in the surface of the mounting main rod, the fixing ring is fixedly connected with the adjusting groove, and the adjusting ring is slidably connected with the adjusting groove. According to the auxiliary purse-string suturing device for the peritoneal dialysis catheterization, the edge of the flexible protective skin is tightly buckled on the inner surface of the peritoneum, so that an intestinal canal and the omentum majus are isolated outside a suturing area, a closed compartment is established, medical staff can conveniently conduct peritoneal purse-string suturing in the protection area of the flexible protective skin, the risk of secondary injury is reduced, and the operation is convenient. And the opening size of the flexible protective leather can be flexibly adjusted, so that the device is suitable for auxiliary work of purse-string suture with different opening sizes.

The present disclosure provides a combination of a liposomal suspension, and of albumin, for use as bile acid sequestrants, wherein the use comprises (a) intraperitoneally administering the liposomal suspension to a subject in need thereof; and (b) intravenously or intraperitoneally administering the albumin to the subject; and (c) removing a dialysate containing liposomes and at least one bile acid from the subject, wherein the at least one bile acid comprises cholic acid, glycocholic acid, glycochenodeoxycholic acid or a combination of at least two thereof.