The invention belongs to the technical field of network communication and computers, particularly relates to an intelligent interactive question and answer method, system and device based on a Markovlogic network, and aims to solve the problems that an intelligent question and answer system cannot effectively combine context and background in practical application, cannot feed back in real time and is low in efficiency. The method comprises the following steps: analyzing input information, extracting a structured tuple, and performing semantic expansion by adopting a domain knowledge map; Activating related rules in the domain knowledge map, assigning values to the evidence tuples by adopting an approximate reasoning and/or information input mode, and calculating the posterior probabilityof the candidate response information; And outputting a preset number of pieces of response information with high posterior probability. According to the method, context operation and domain uncertainty knowledge can be effectively fused, approximate deduction and user interaction are powerfully combined, an effective solution is truly provided, meanwhile, automatic induction of knowledge can beachieved, and labor and data cost is reduced.