32results about "Accelarator mass spectrometers" patented technology

A method for performing accelerator mass spectrometry, includes producing a beam of positive ions having different multiple charges from a multicharged ion source; selecting positive ions having a charge state of from +2 to +4 to define a portion of the beam of positive ions; and scattering at least a portion of the portion of the beam of positive ions off a surface of a target to directly convert a portion of the positive ions in the portion of the beam of positive ions to negative ions.

This invention relates to a method and apparatus for separation of rare stable or radioactive isotopes from their atomic or molecular isobars in mass spectrometry (MS). In the present invention, the approach taken to removing atomic isobars utilizes a high transmission device for decelerating ions in combination with low energy reactions, such as ion-molecule reactions or near resonant electron transfer, in RF ion guides. The isobar is selectively depleted by electron transfer or other reactions between negative ions and gaseous targets in pressurized RF ion guides at low energies. The energy is controlled in such a way as to prevent reaction of the ion of interest while inducing reactions with the undesired isobar interference. The technique is of particular relevance to accelerator mass spectrometry (AMS) for which it allows substantial reductions in the necessary terminal voltage. The effect is to allow reductions in the size and cost of AMS installations.

The present invention provides a method of sample preparation for use in obtaining elemental isotope ratios of a material by accelerator mass spectrometry. The method comprises forming the material into a sample without any substantial chemical alteration of the material. The invention also provides a sample for use in obtaining elemental isotope ratios of a material.

The invention provides a calibrating method for use in a method of determining the quantity of an analyte labelled with an AMS isotope in a test sample, said calibrating method comprising: (i) contacting a plurality of samples contaminated with neither said analyte nor a non-labelled counterpart analyte with a known quantity of said counterpart analyte and a quantity C of analyte to afford a plurality of calibrating samples, wherein each of said calibrating samples contains a known quantity of counterpart analyte but a different quantity of C; (ii) measuring by AMS the quantity C of analyte added to each of the plurality of samples; (iii) separating the analyte and counterpart analyte from other species in the plurality of samples to afford a plurality of purified samples; (iv) measuring a quantity A of analyte in said purified samples by AMS; and (v) measuring a quantity B of counterpart analyte in said purified samples.

The analyst previously enters the mass of a fragment that desorbs in the first dissociation with other analysis conditions, as the precursor ion selection reference for the second dissociation through the input unit 25. When the automatic analysis is started, the controller unit 21 sequentially performs the MS1 analysis, MS2 analysis and MS3 analysis. In the course of these analyses, the data processing unit 23 determines the valence of each ion species corresponding to the peaks appearing in the mass spectrum obtained by the MS1 analysis. In addition, after the MS2 analysis, the data processing unit 23 searches for the ion species in conformity with the selection reference in consideration of the determined valence, among the ion species corresponding to the peaks appearing in the mass spectrum by the MS2 analysis. The selected ion is determined as the precursor ion for the second dissociation in the MS3 analysis. In this manner, regardless of the valence of the target ion, the precursor ions to be selected and dissociated in each stage of the MSn analysis are automatically selected according to the mass of the fragment desorbed in the dissociation in the previous stage. Therefore, the analytical efficiency is improved and the highly accurate chemical structure information can be obtained.

The present invention relates to improved methods for measuring the renewable bio-source carbon content and renewable bio-content in renewable bioplastic resins produced in manufacturing plants. In particular, the present invention relates to measuring the renewable bio-source carbon content in renewable bioplastic resins produced during a production run by correlating measured δ13C values are measured by iTOC-CRDS and CM-CRDS with actual renewable bio-source carbon content measurements (AMS or LSC14C) via a linear regression.

The double-injection tadem accelerator mass spectrometer is characterized by that its injection system comprises double-focussing speed analzer, static quadrupole lens and mass recombiner. On the premise of no changing detected nuclide species and accuracy said inventino can reduce its cost, and possesses the advantages of simpe structure and operation, and is applicable to detection analysis of various long-life radionuclides.

A method of treating a particle beam is disclosed, of interest in particular for mass spectrometry for 14C. A particle beam including positive ions is passed through a charge exchange cell containing a target gas. The target gas is electrically insulating at room temperature and pressure. At least some of the positive ions of the particle beam are converted to negative ions by interaction with the target gas. The particle beam incident at the charge exchange cell includes molecules and / or molecular ions which interact with the target gas to reduce the concentration of molecules as a result of repeated collisions with particles of the target gas. A corresponding mass spectrometry system is also disclosed.

The embodiment of the application provides an accelerator mass spectrometry system and relates to the technical field of AMS. The accelerator mass spectrometry system comprises an ECR strong current positive ion source subsystem, an injector subsystem, a strong current accelerator subsystem, a high-energy analysis subsystem and a high-resolution detector subsystem which are successively connected.The ECR strong current positive ion source subsystem is configured to generate strong current positive ions in multiple charge states. The strong current accelerator subsystem is configured to directly accelerate the strong current positive ions. The accelerator mass spectrometry system has the advantages of strong beam current, high total efficiency, and good background lowering capability, andcan greatly improve the abundance sensitivity of the spectrometry.

The invention discloses a rapid online analyzer for <14>C-AMS (Accelerator Mass Spectrometry). The rapid online analyzer comprises a solid-sample treating module, an atmosphere-sample collecting and treating module, a micro-flow control module, an AMS module and an automatic control module. The rapid online analyzer disclosed by the invention has the beneficial effects that sample preparation andAMS measurement are fused, not only can <14>C samples (including solid samples and atmosphere samples) be analyzed in a rapid and high-efficiency manner and can the possibility that the samples are polluted be reduced, but also the capabilities of analyzing and testing the <14>C samples can be greatly improved for an AMS laboratory in a limited machine hour, and meanwhile another scheme with faster speed and stronger anti-pollution capability also can be provided for measuring extremely-trace samples (the content is a few of micrograms); the solid original samples are directly transformed intoCO2 gas to be subjected to AMS measurement without being specially treated by a chemical laboratory, the atmosphere samples can be collected in real time for AMS analysis, so that the process of firstly preparing the samples and then carrying out <14>C-AMS measurement in the original special chemical laboratory is completely changed.

An accelerator mass spectrometry system for measuring an isotopic ratio of a chemical element in a sample. The system includes an ion source generating a beam of negative ions of the chemical element containing ions of first and second isotopes of the chemical element, a first analyzer section, comprising a first mass analyzer; a tandem accelerator comprising a first accelerating section, a charge stripping section for converting the negative ions into positive ions, and a second accelerating section behind the charge stripping section. A second analyzer section includes a second mass analyzer and an electrostatic analyzer; a particle detector; and a controller system configured to control the first mass analyzer section and the second analyzer section such that the ions of the first and second isotopes traverse the tandem accelerator and ions of only one of the first and second isotopes enter the particle detector. An additional analyzer is located in between the charge stripping section and the second accelerating section and is configured to receive positive ions that have exited the charge stripping section and to separate positive ions having a charge state corresponding to a predetermined charge-state value from positive ions having a charge state not corresponding to the predetermined charge-state value, so as to transmit ions with different charge states in mutually different directions such that only ions having a charge state corresponding to the predetermined charge-state value are transmitted towards the particle detector.

The invention discloses an inorganic mass spectrometer, which is an inorganic mass spectrometer based on a multi-charge-state ion source, and the specific structure of the inorganic mass spectrometer comprises a multi-charge-state ion source, a front-end analysis system, a rear-end subsystem and an ion detector. The multi-charge-state ion source is connected with the front-end analysis system, the front-end analysis system is connected with the rear-end analysis system, and the rear-end analysis system is connected with the ion detector. The instrument has the capabilities of eliminating molecular backgrounds and lowering isotopic element backgrounds, and also has the advantages of strong beam current, high transmission efficiency and the like, so that the measurement sensitivity and the measurement precision of the inorganic mass spectrometer are remarkably improved.

An object of the present invention is to provide a mass spectrometer and a mass separator whose design and performance are less restricted by problems arising from the principle of operation, and which have in principle no limitation on the mass-to-charge ratio range to be able to deal with and are each capable of repeatedly analyzing or extracting plural ionic species of different mass-to-charge ratios in a short time.A mass spectrometer (10) is configured from an ion source (1), an ion introduction unit (2), a mass analyzer (3), an ion detection unit (4), and the like. Crude ions are introduced into a separation space (5) at a predetermined acceleration voltage as a pulse synchronized with the phase of a one-dimensional high-frequency electric field. In the separation space (5), each ion travels in an incident direction by inertia, and besides they are displaced by force received from the one-dimensional high-frequency electric field which acts in the y-direction crossing the incident direction. Ionic species having different mass-to-charge ratios with each other are separated by the difference in displacement magnitude. At this time, the acceleration voltage and the period of the one-dimensional high-frequency electric field are set in order that the measured ionic species may exit from the separation space (5) having received the action of the electric field for one period.

The embodiment of the invention provides an accelerator mass spectrum device for isotope measurement. The device comprises an ion source, an injection system, an accelerating tube, a gas stripping system, an analysis system and a detection system; the ion source is connected with the injection system, the output end of the injection system is connected with the accelerating tube, the output end ofthe accelerating tube is connected with the gas stripping system, the output end of the gas stripping system is connected with the analysis system, and the analysis system is connected to the detection system; the ion source is used for generating isotope anions; the injection system separates isotope anions and injects the isotope anions into the accelerating tube alternately; the accelerating tube accelerates the anions separated by the injection system; the gas stripping system converts the accelerated negative ions into positive ions and disintegrates molecular ions; the analysis system analyzes the positive ions and then sends the positive ions to the detection system, and the detection system measures the positive ions. The device is compact in structure, and the related operation process is simple.

The present invention provides an accelerator mass spectrometry device for simultaneously measuring isotopes. In one embodiment, the device comprises a sputtering negative ion source for generating negative ions; the sputtering negative ion source being connected to an accelerating tube for simultaneously accelerating a plurality of isotopic ions; an output end of the accelerating tube being connected to an isotope mass resolution system; the isotope mass resolution system being connected to a charge conversion analysis and multi-receiving measurement system; the charge conversion analysis and multi-receiving measurement system being connected to an ion detection system. The present invention is capable of accelerating a plurality of isotopic negative ions simultaneously. The accelerated isotopic negative ions are separated. Stable isotopic negative ions are measured by a stable isotope receiver. Unstable isotope negative ions are converted to positive ions and then measured by a detector.

A shielding plate 6 having a forward-side slit opening 61 and return-side slit opening 62 is placed in a free flight space 3 with no electric field. Ions which significantly deviate from a reference path are removed by the shielding plate 6 on both the forward-side and return-side paths. The opening width of the forward-side slit opening 61 is smaller than that of the return-side slit opening 62. Those opening widths and the placement position of the shielding plate 6 are determined based on the result of an ion trajectory calculation by accurate simulation. As compared to a conventional device with a shielding plate placed only on the return side, the present configuration allows for an increase in the opening width of the return-side slit opening while achieving the same level of resolving power. The ion transmission ratio is thereby improved, and the analytical sensitivity is enhanced.

A method of treating a particle beam is disclosed, of interest in particular for mass spectrometry for 14C. A particle beam including positive ions is passed through a charge exchange cell containing a target gas. The target gas is electrically insulating at room temperature and pressure. At least some of the positive ions of the particle beam are converted to negative ions by interaction with the target gas. The particle beam incident at the charge exchange cell includes molecules and / or molecular ions which interact with the target gas to reduce the concentration of molecules as a result of repeated collisions with particles of the target gas. A corresponding mass spectrometry system is also disclosed.

The invention provides a mass spectrum system and a measurement method thereof. The mass spectrum system comprises an ion source subsystem, an ion accelerator subsystem, a high-energy analyzer subsystem and a particle identification and detector subsystem which are connected in sequence. The ion source subsystem comprises a sample injector component and a super-strong ionization ion source component connected with the sample injector component; the high-energy analyzer subsystem comprises an analyzer component connected with the ion accelerator subsystem and a beam measurement component connected with the analyzer component; and the detector subsystem comprises a thin film connected with the beam measurement component and a detector connected with the thin film. Interference of molecular ions is eliminated by adopting a super-strong ionization technology; the size of the atomic number Z can be detected by adopting a particle identification technology, so that the same amount of ectopic ions and the information of ions with different mass numbers but the same M / q, namely ZM / q information, are obtained, and finally, the real mass spectrum measurement is realized.

The invention relates to a multi-mass-to-charge-ratio ion beam mass spectrometry device and method. The multi-mass-to-charge-ratio ion beam mass spectrometry device comprises an ion source, a focusingmodule, a magnetic separation module, an acquisition module and a data processing module. The ion source is used for emitting an ion beam comprising ions with multiple mass-to-charge ratios; the focusing module is used for focusing the ion beam; the magnetic separation module is used for separating ions with different mass-to-charge ratios in the focused ion beam along different curvature radiuses according to the magnetic stiffness; the acquisition module is arranged at the ion beam imaging end of the magnetic separation module and is used for receiving the ions with different mass-to-chargeratios corresponding to the curvature radiuses and generating corresponding electric signals; and the data processing module is connected with the acquisition module, and is used for determining thetypes and proportions of ions with different mass-to-charge ratios according to the curvature radius and the electric signals generated by the acquisition module. The device solves the problems that in the prior art, the device is long in distinguishing time, and the application range is narrow due to the fact that the sample component proportion distinguishing capacity is insufficient.

An accelerator mass spectrometry measuring system is disclosed, including: an ECR high-current positive ion source subsystem; an injector subsystem; a high-current accelerator subsystem; a high-energy analysis subsystem; and a high-resolution detector subsystem; of which, the ECR high-current positive ion source subsystem, the injector subsystem, the high-current accelerator subsystem, high-energy analysis subsystem and a high-resolution detector subsystem are connected sequentially; the ECR high-current positive ion source subsystem is configured for generating high-current positive ions of multi-charge states; the high-current accelerator subsystem is configured for accelerating the high-current positive ions. The AMS system is high in beam, high in overall efficiency, and strong in how-down capability, and can greatly improve the abundance sensitivity of measurement.

An accelerator mass spectrometry system for measuring an isotopic ratio of a chemical element in a sample. The system includes an ion source generating a beam of negative ions of the chemical element containing ions of first and second isotopes of the chemical element, a first analyzer section, comprising a first mass analyzer; a tandem accelerator comprising a first accelerating section, a charge stripping section for converting the negative ions into positive ions, and a second accelerating section behind the charge stripping section. A second analyzer section includes a second mass analyzer and an electrostatic analyzer; a particle detector; and a controller system configured to control the first mass analyzer section and the second analyzer section such that the ions of the first and second isotopes traverse the tandem accelerator and ions of only one of the first and second isotopes enter the particle detector. An additional analyzer is located in between the charge stripping section and the second accelerating section and is configured to receive positive ions that have exited the charge stripping section and to separate positive ions having a charge state corresponding to a predetermined charge-state value from positive ions having a charge state not corresponding to the predetermined charge-state value, so as to transmit ions with different charge states in mutually different directions such that only ions having a charge state corresponding to the predetermined charge-state value are transmitted towards the particle detector.

The double-injection tadem accelerator mass spectrometer is characterized by that its injection system comprises double-focussing speed analzer, static quadrupole lens and mass recombiner. On the premise of no changing detected nuclide species and accuracy said inventino can reduce its cost, and possesses the advantages of simpe structure and operation, and is applicable to detection analysis of various long-life radionuclides.

A shielding plate 6 having a forward-side slit opening 61 and return-side slit opening 62 is placed in a free flight space 3 with no electric field. Ions which significantly deviate from a reference path are removed by the shielding plate 6 on both the forward-side and return-side paths. The opening width of the forward-side slit opening 61 is smaller than that of the return-side slit opening 62. Those opening widths and the placement position of the shielding plate 6 are determined based on the result of an ion trajectory calculation by accurate simulation. As compared to a conventional device with a shielding plate placed only on the return side, the present configuration allows for an increase in the opening width of the return-side slit opening while achieving the same level of resolving power. The ion transmission ratio is thereby improved, and the analytical sensitivity is enhanced.

A method for discriminating a polyvinyl alcohol resin film containing a polyvinyl alcohol resin in which all or a part of carbon is derived from bio-derived ethylene from a polyvinyl alcohol resin film containing only a polyvinyl alcohol resin derived only from fossil fuel-derived ethylene by measuring an abundance ratio 14C / C of carbon 14 (14C) in total carbon.

Disclosed herein is a method for evaluating and measuring the performance, efficacy and safety of candidate new chemical entities. This method comprises employing a target compound having one or more 12C atoms in the molecule wherein at least one of the 12C atoms is substituted with a 13C atom, The stable labelled target compound is then administered to a test subject following which the target compound and / or one or more of its metabolites are recovered using conventional separation techniques and purified. The resulting isolated material of interest is then combusted in the presence of a petrochemical based carrier, the 12C content of such carrier with respect to naturally occurring 13C being in excess of 99.9 percent. The CO2 resulting from such combustion is then graphitized and the graphitized material is analyzed employing techniques, such as Accelerator Mass Spectrometry (“AMS”), capable of differentiating and counting the carbon atom isotopes (13C vs. 12C), thus allowing quantification of the compound / metabolite of interest.