The invention belongs to the technical field of infrastructures of marine engineering, and discloses a multi-cylinder combination infrastructure with a supporting structure and a construction method of the multi-cylinder combination infrastructure. The multi-cylinder combination infrastructure comprises a plurality of steel cylinders which are annularly arranged and mutually welded, the upper parts of the multiple steel cylinders are connected with a steel top plate, a concrete plate is arranged on the steel top plate, the top face of the concrete plate is provided with an outer ring beam, a middle ring beam, an inner ring beam, a concrete main beam, a first concrete secondary beam and a second concrete secondary beam, the upper part of the middle ring beam is connected with a concrete transition section, and the supporting structure is arranged in the concrete transition section. The construction method of the multi-cylinder combination infrastructure comprises the steps such as landprefabrication, shore hoisting, water towage, negative pressure sinking and negative pressure reinforcement. The multi-cylinder combination infrastructure has the advantages of a gravity-type foundation and a cylinder-type foundation, is wide in application range, convenient to transport and mount, recyclable, and high in carrying capacity, can serve as a top-bearing-type structure, can also convert an upper fan load into structure-controlled pulling and pressing stress, and can also serve as a gravity-type structure to resist the upper load through the own gravity.