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Preparation method of organic/inorganic hybrid nano fiber drug carrying microsphere

A drug-loaded microsphere and inorganic technology, which is applied in the field of preparation of drug-loaded porous microspheres, can solve the problems of increasing the amount of drug-loaded therapeutic drugs on the spheres, achieve drug delivery and long-term release, simple experimental equipment, and simple synthesis process Effect

Inactive Publication Date: 2014-05-21
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] In addition, porous microspheres need to be improved in terms of improving the stability of drugs, ensuring that drugs do not leak in advance during the preparation process, increasing the drug loading of spheres or slowing down the burst release of therapeutic drugs.

Method used

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  • Preparation method of organic/inorganic hybrid nano fiber drug carrying microsphere
  • Preparation method of organic/inorganic hybrid nano fiber drug carrying microsphere

Examples

Experimental program
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Effect test

Embodiment 1

[0029] Preparation of composite hybrid porous microspheres loaded with doxorubicin hydrochloride mesoporous silica nanoparticles / poly(lactic-co-glycolic acid) for tumor therapy.

[0030] (1) Prepare mesoporous silica nanoparticles and load them with doxorubicin hydrochloride (mesoporous silica nanoparticles can be purchased or synthesized by yourself, taking the reported mesoporous silica nanoparticles as an example. Drug-loaded media Pore ​​silica nanoparticle preparation process is as follows.Step 1: prepare mesoporous silicon nanoparticle.The cetyltrimethylammonium bromide of 1.8 grams and the ammonium fluoride of 3.0 grams are dissolved in 500 milliliters of deionized water, Stir at 80°C for 1 hour, add 9 ml of tetraethyl orthosilicate dropwise, stir at 80°C for 2 hours, centrifuge, wash with water and ethanol, collect and put in 4 ml of hydrochloric acid and 200 ml of anhydrous In the mixed solution of ethanol, reflux at 90°C for 20 hours, dry and load the drug. Step 2: P...

Embodiment 2

[0036] Preparation of composite hybrid porous microspheres loaded with gentamicin hydroxyapatite nanoparticles / polylactic acid copolymer for antibacterial application.

[0037] (1) Preparation of hydroxyapatite nanoparticles loaded with gentamicin. (Wherein, hydroxyapatite nanoparticles can be purchased, or can be synthesized according to literature reports, taking the reported hydroxyapatite synthesis as an example. The preparation process of drug-loaded hydroxyapatite nanoparticles is as follows. Step 1: take calcium oxide Add the powder into a beaker filled with distilled water, stir to form a calcium hydroxide suspension with a concentration of 0.5 mol / liter, and add phosphoric acid with a concentration of 2.5 mol / liter dropwise at a temperature of 50°C, and add phosphoric acid solution The molar ratio to calcium hydroxide is 6:10, and the hydroxyapatite sol is obtained by standing for 48 hours. After that, the gel is collected, dried at 120°C for 6 hours, and then calcine...

Embodiment 3

[0043] Preparation of composite hybrid porous microspheres of hollow silica nanospheres / poly(lactic-co-glycolic acid) loaded with recombinant human bone morphogenetic protein for antibacterial application.

[0044] (1) Preparation of hollow silica nanospheres loaded with recombinant human bone morphogenetic protein. (Wherein, hollow silica nanoparticles can be purchased or synthesized by oneself, taking the reported hollow silica nanospheres as an example. The preparation process of drug-loaded hollow silica nanospheres nanospheres is as follows. Step 1: Weigh respectively 1.0 grams of tetraethyl orthosilicate, 5 milliliters of ammonia water, 40 milliliters of ethanol, and 5.0 grams of polystyrene balls were reacted at 50°C for 1.5 hours, and the precipitate was collected and calcined at 550°C for 10 hours to obtain hollow silica nanoparticles. Ball. Step 2: Prepare an aqueous solution of 10 mg / ml recombinant human bone morphogenetic protein-2, add 1 gram of hollow silicon dio...

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Abstract

The invention relates to a preparation method of organic / inorganic hybrid nano fiber drug carrying microspheres. The preparation method comprises the following steps of (1) preparing drug carrying nano particles, preparing a high-molecular polymer solution; (2) adding the drug carrying nano particles into the polymer solution, dispersing with ultrasonic wave, stirring, to prepare a homogeneous mixed solution; (3) adding hydrogen peroxide into the mixed solution, oscillating with ultrasonic wave under an ice bath condition, to obtain a water-in-oil primary emulsion; and (4) preparing an external water phase solution, adding the external water phase solution into the water-in-oil primary emulsion drop by drop, oscillating with ultrasonic wave or homogenizing mechanically, to form an oil-in-water-in-oil secondary emulsion, stirring until the residual organic solvent is volatilized completely, collecting microspheres, and drying by freezing, so as to obtain products. The hybrid nano fiber drug carrying microspheres prepared by the preparation method have low density, large specific surface area, high surface infiltration capacity, are safe and nontoxic, are degradable, have excellent biocompatibility and can be controlled to release for a long time, and therefore, the application prospect is wide.

Description

technical field [0001] The invention belongs to the field of preparation of drug-loaded porous microspheres, in particular to a method for preparing organic / inorganic hybrid drug-loaded porous microspheres. Background technique [0002] As a new type of drug delivery carrier, microspheres have the characteristics of small size, diverse carrier materials, good biocompatibility, and are suitable for a variety of drug delivery methods. Has certain advantages. Among them, porous microspheres, as a kind of tiny spherical entities with special surface morphology, have gradually been widely studied. Porous microspheres have some unique advantages while maintaining the characteristics of traditional microspheres. For example, the porous structure reduces the density of the microspheres themselves, improves the aerodynamic properties of the spheres, facilitates inhalation drug delivery, and improves the absorption of target drug molecules in the lungs and other organs. Distribution...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K9/51B82Y30/00B82Y40/00
Inventor 何创龙冯炜陈良周小军聂伟仇可新
Owner DONGHUA UNIV
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