Method for preparing coating with nitric oxide (NO) catalytic activity

Abstract

The invention discloses a method for preparing a coating with nitric oxide catalytic activity. The method comprises the following steps: mixing a selenium-containing compound, a sulfur-containing compound and a soluble copper salt with the NO catalytic activity with a compound of an o-phenol structure, a flavone compound and a flavonol compound or a flavanone compound in a buffer solution for polymerizing. The coating with the nitric oxide catalytic activity can be applied to surface modification of matrix materials of almost all the materials, geometrical shapes and topological structures. The double selenium bonds, double sulfur bonds, copper ions and phenolic hydroxyl group in the prepared coating with the nitric oxide (NO) catalytic activity have excellent free radical scavenging functions; and the selenium bonds, sulfur bonds and chelated copper ions contained in the material have the response functions on reduced glutathione (GSH). In addition, the copper ions contained in the coating have antibacterial functions. The coating is used for catalyzing NO release and also can be applied to all the fields related to free radical scavenging and GSH response functions.

Description

technical field [0001] The invention relates to a preparation technology for preparing a coating with catalytic activity of nitrogen monoxide. Background technique [0002] Nobel Prize winners Murad and Ignarro discovered more than 30 years ago that the cell signaling factor NO is a key factor in maintaining the balance of the cardiovascular system. NO is mainly produced by endothelial cells through the action of nitric oxide synthase secreted by endothelial cells and arginine. The sustained release of NO is an important factor in maintaining cardiovascular homeostasis and regulating vasodilation. In addition, the researchers also found that NO has many important biological effects, such as: inhibition of platelet activation, smooth muscle proliferation and leukocyte activation. It also has important biological functions in immune response, anticancer, antibacterial and atherosclerotic treatment. It is worth mentioning that the study found that NO also plays an important r...

AI Technical Summary

Problems solved by technology

However, there are many shortcomings in the application of NO catalytically active materials reported so far, such as: (1) The catalytically active materials with GPx are usually grafted on the surface, and the amount of grafting is limited, resulting in the amount of NO catalytically released Small, it is difficult to apply to the environment where large doses of NO are required; (2) Since the synthesized NO catalytic active material has no strong binding site with the material substrate, its stability is poor, and it is difficult to maintain long-term NO catalytic release