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Magnetic hyperbranched polymer or magnetic hyperbranched polymer derivative blood heavy metal ion adsorbent and preparation method and application thereof

A technology of hyperbranched polymers and heavy metal ions, which is applied in the field of biomedical materials and its preparation, can solve the problems of heavy metal ion adsorbents that cannot be directly applied and low ion concentration, avoid non-specific adsorption, simple process, and mild synthesis conditions Effect

Active Publication Date: 2017-06-30
NANJING NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The challenges of absorbing heavy metal ions in the blood include: 1. Low ion concentration: The content of heavy metal ions in blood is much lower than that in sewage. According to the data analysis in the National Occupational Health Standard of the People's Republic of China "Diagnostic Criteria for Occupational Chronic Lead Poisoning" , blood lead content exceeding 0.6ppm is the starting point for the diagnosis of lead poisoning, while the concentration of lead ions in common sewage is 10-100ppm; 2. Competitive adsorption: because heavy metal ions are distributed in blood in two ways: i. Mainly with hemoglobin and white Complexation of proteins, etc.; ii. Part of it exists in the form of free state, and there is also a dynamic balance between the two forms of existence. The foreign adsorbent must not only be able to quickly chelate free heavy metal ions, but also need to compete with the protein for adsorption and complexation. The ability of heavy metal ions; 3. Blood compatibility requirements: heavy metal ion adsorbents in blood must have excellent blood compatibility, and have no destructive effect on red blood cells, platelets and other components; 4. Selective adsorption: only selectively adsorb heavy metal ions, It has no adsorption effect on normal metal ions (such as sodium, potassium, etc.) in blood
The above challenges prevent heavy metal ion adsorbents commonly used in water from being directly applied to blood

Method used

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  • Magnetic hyperbranched polymer or magnetic hyperbranched polymer derivative blood heavy metal ion adsorbent and preparation method and application thereof
  • Magnetic hyperbranched polymer or magnetic hyperbranched polymer derivative blood heavy metal ion adsorbent and preparation method and application thereof
  • Magnetic hyperbranched polymer or magnetic hyperbranched polymer derivative blood heavy metal ion adsorbent and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Preparation of magnetic Fe3O4 nanoparticles

[0022] Weigh 3.4g of hexahydrate and ferric chloride and 1.5g of tetrahydrate and ferrous chloride, and dissolve them in 33.6ml of water to obtain a mixed aqueous solution of ferric chloride and ferrous chloride. Continuously feed N into the mixed aqueous solution of ferric chloride and ferrous chloride 2 After heating up to 25°C, quickly add 13.8ml of ammonia water (ammonia water 26%), stir vigorously, heat up to 80°C and continue to react for 1h, add 1.5g of oleic acid dropwise, and continue to react at 80°C for 1h. After naturally cooling to room temperature, magnetically separate, pour out the water, ultrasonically wash with ethanol and acetone, magnetically separate, collect the solid product, and vacuum dry at 70°C for 3 hours to obtain magnetic Fe3O4 nanoparticles. The transmission electron microscope picture of the obtained magnetic ferroferric oxide nanoparticles is as follows figure 2 As shown in A, by fig...

Embodiment 2

[0032] (1) Preparation of ferric oxide-dopamine nanoparticles

[0033] Prepare 10mg ml with the magnetic iron ferric oxide nanoparticles prepared in Example 1 step (1) -1 Magnetic ferric oxide-chloroform solution, take 5ml of the 10mg·ml -1 of ferric oxide-chloroform solution with 20ml25mg·ml -1 The dopamine Tris-HCl buffer solution was mixed and stirred, and reacted for 6 hours at a reaction temperature of 80° C. to obtain ferric oxide-dopamine nanoparticles.

[0034] (2) Modification of hyperbranched polymers

[0035] Disperse the ferric iron tetroxide-dopamine nanoparticles prepared in step (2) in water to prepare 10 mg ml -1 For the dispersion of ferric oxide-dopamine nanoparticles in water, take 5ml of the 10mg ml -1 The dispersion of ferriferric oxide-dopamine nanoparticles in water was mixed with 5 ml of glutaraldehyde aqueous solution with a mass fraction of 6% at room temperature, stirred and reacted for 12 hours, and the reaction temperature was 4°C. After the r...

Embodiment 3

[0037] (1) Preparation of ferric oxide-dopamine nanoparticles

[0038] Prepare 10mg ml with the magnetic iron ferric oxide nanoparticles prepared in Example 1 step (1) -1 Fe3O4-chloroform solution, take 5ml of the 10mg·ml -1 of ferric oxide-chloroform solution with 1ml 50mg·ml -1 The dopamine Tris-HCl buffer solution was mixed and stirred, and reacted for 6 hours at a reaction temperature of 60° C. to obtain ferric oxide-dopamine nanoparticles.

[0039] (2) Modification of hyperbranched polymers

[0040] Disperse the ferric iron tetroxide-dopamine nanoparticles prepared in step (2) in water to prepare 10 mg ml -1 For the dispersion of ferric oxide-dopamine nanoparticles in water, take 5ml of the 10mg ml -1 The dispersion of ferriferric oxide-dopamine nanoparticles in water was mixed with 5 ml of glutaraldehyde aqueous solution with a mass fraction of 6% at room temperature, stirred and reacted for 12 hours, and the reaction temperature was 50°C. After the reaction, adjust...

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Abstract

The invention provides a magnetic hyperbranched polymer or magnetic hyperbranched polymer derivative blood heavy metal ion adsorbent and a preparation method thereof. The preparation method includes: 1) modifying the surfaces of magnetic ferroferric oxide nanoparticles with polydopamine layers to obtain magnetic ferroferric oxide-polydopamine; and 2) mixing the obtained magnetic ferroferric oxide-polydopamine with a cross-linking agent in a solvent for a reaction, adjusting pH of the solution to 7.5-9, adding hyperbranched polymer, and carrying out a reaction while performing stirring to prepare the magnetic hyperbranched polymer or magnetic hyperbranched polymer derivative blood heavy metal ion adsorbent. The adsorbent can effectively capture trace heavy metal ion in blood, is high in biocompatibility, can selectively adsorb heavy metal ions, and prevents nonspecific adsorption of other elements in blood and the adsorbent itself from affecting blood components. The method is simple in process, mild in synthetic condition, short in production cycle, and suitable for industrial production and has bright application prospects in the medical field.

Description

technical field [0001] The invention relates to a biomedical material and its preparation method and application, in particular to a magnetic hyperbranched polymer or its derivative heavy metal ion adsorbent and its preparation method and application. Background technique [0002] With the rapid development of industrialization and the intensification of human destructive activities, pollutants containing heavy metal ions are increasingly diffused into the atmosphere, water, and soil (food chain), and thus enter the human body for deposition. In addition, drug therapy also has the risk of accumulation of heavy metal ions in the body, such as platinum in chemotherapy and bismuth often contained in gastric medicine. Studies have shown that heavy metals can change the structure of proteins, thereby affecting the normal function of tissue cells. When the deposition of heavy metals in the body exceeds a certain amount, due to their high toxicity, non-biodegradability, bioaccumul...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/28B01J20/30
CPCB01J20/26B01J20/28009
Inventor 毛春陈焕万密密周倩孙佳佳
Owner NANJING NORMAL UNIVERSITY
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