3D printed heart stent for cardiac interventional surgery

Abstract

The invention provides a 3D printed heart stent for a cardiac interventional surgery. The 3D printed heart stent for the cardiac interventional surgery comprises poly-L-lactic acid as a matrix polymerizer, and a toughening agent, starch, a filler, a lubricant and a stabilizer as auxiliary agents. The 3D printed heart stent for the cardiac interventional surgery is prepared by blending, dissolving,filtering and concentrating the poly-L-lactic acid as the matrix polymerizer, and the toughening agent, the starch, the filler, the lubricant and the stabilizer as the auxiliary agents to obtain a printing paste, and finally performing 3D printing. The 3D printed heart stent for the cardiac interventional surgery comprises the poly-L-lactic acid, is a biodegradable material, does not contain anymetal component and is not affected by a magnetic field, so that examination of nuclear magnetic resonance is not affected; meanwhile, formation of a thrombus is unlikely, long-time use of an anticoagulant medicine for preventing thrombosis is not required, and after vascular functions are restored in a body, the 3D printed heart stent can be completely dissolved by itself and the rate of restenosis is extremely low.

Description

Technical field [0001] The invention relates to the field of medical technology, in particular, the invention relates to a 3D printed cardiac stent for cardiac interventional surgery. Background technique [0002] Myocardial infarction results in the loss of heart muscle and the formation of non-contracting scar tissue. Although surgery and medical treatment improve the likelihood of survival, these interventions cannot compensate for the loss of cardiomyocytes. Therefore, there is a continuing need to seek new strategies to restore the structural and functional features of the damaged heart. [0003] Traditional metal stents play an important role in the process of restoring the damaged heart. Metal stent wires permanently exist in blood vessels, and complications such as in-stent thrombosis and in-stent restenosis may occur, manifested as intimal hyperplasia, a large number of smooth muscle cells Increased proliferation and extracellular matrix secretion may cause angina...

AI Technical Summary

Problems solved by technology

[0003] Traditional metal stents play an important role in the process of restoring the damaged heart. Metal stent wires permanently exist in blood vessels, and complications such as in-stent thrombosis and in-stent restenosis may occur, manifested as intimal hyperplasia, a large number of smooth muscle cells Increased proliferation and extracellular matrix secretion may cause angina pectoris and myocardial infarction. About 20% of patients may have acute myocardial enzyme positive. Once it occurs, patients generally need to undergo interventional therapy again. Due to the influence of stent wire, it is more difficult to deal with. Difficult, often need to cover the stent within the stent, which itself increases the risk of thrombosis in the stent, and there are rare occurrences such as stent wire breakage

[0004] Therefore, the field needs to develop a cardiac stent with higher mechanical strength, better biocompatibility and reliable expansion performance, so as to avoid the damage of intradermal cell structure and function, thrombosis in the stent and The emergence of internal restenosis, angina pectoris, myocardial infarction and other problems, and solve the limitations of poor support force in the use of common cardiac stent materials

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