Composite scaffold for hip articular cartilage repair and preparation method of composite scaffold

A technology of cartilage repair and composite scaffold, applied in the direction of hip joints, joint implants, joint implants, etc., can solve the problem of high product brittleness, mechanical strength that cannot meet clinical mechanical support requirements, and difficulty in achieving cartilage microenvironment and osteogenesis Effective isolation of microenvironment and other problems to prevent cartilage ossification and maintain stability

Active Publication Date: 2020-07-17
赵德伟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, some researchers tried to simulate the calcified interface layer through structural bionics by using hydrogel materials through ionic cross-linking, but the mechanical properties of pure hydrogel could not meet the mechanical support requirements of the calcified interface layer and subchondral bone layer; The ceramic calcified interface layer was prepared by sintering the inorganic material through preliminary structural design and 3D integrated printing technology, but the product is highly brittle and difficult

Method used

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  • Composite scaffold for hip articular cartilage repair and preparation method of composite scaffold
  • Composite scaffold for hip articular cartilage repair and preparation method of composite scaffold
  • Composite scaffold for hip articular cartilage repair and preparation method of composite scaffold

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Example steps for preparing porous magnesium stents by infiltration casting method: put spherical sodium chloride crystal particles with a size of 700-800 μm into a mold with an inner diameter of 50 mm and a height of 50 mm, put the mold into a vacuum heat treatment furnace and sinter at a constant temperature of 700 ° C for 12 hours, Cooling with the furnace to obtain the open-pore porous sodium chloride preform; pour the Mg-3wt.%Nd-0.2wt.%Zn-0.5wt.%Zr alloy melt into the mold cavity with the open-pore porous sodium chloride preform , under the pressure of 2MPa, the pressure seepage casting is carried out; the outer skin of the sodium chloride-magnesium alloy composite structure is removed by a lathe, and the open-pore porous magnesium alloy can be obtained by washing with tap water for 1 hour, which is further processed into a pot-shaped porous magnesium alloy by mechanical processing.

[0034] Example steps of calcium phosphorus coating on the surface of porous magnes...

Embodiment 2

[0043] Example steps for preparing porous magnesium stents by 3D printing method: 3D printing process parameters are: magnesium powder is spherical powder, particle size is 15-45 μm, powder coating thickness is 30 μm, laser power is 80W, exposure time is 20 μs, laser scanning point spacing 30μm, the line spacing is 30μm, and the printing process is carried out under the protection of argon.

[0044] Example steps of calcium phosphorus coating on the surface of porous magnesium stent: put the porous magnesium alloy prepared above into KH containing 0.025M 2 PO 4 and 0.025M Ca(NO 3 ) 2 The reaction solution was put into a drying oven and reacted at 80°C for 12 hours; the residual reaction solution was removed by cleaning with ultrapure water in an ultrasonic cleaner for 10 minutes, and a porous magnesium alloy with a uniform calcium-phosphorus coating on the surface was obtained.

[0045] The nano-hydroxyapatite powder was prepared into a slurry, and about 2.5 grams was evenl...

Embodiment 3

[0054] Example steps for preparing porous magnesium stents by infiltration casting method: put spherical sodium chloride crystal particles with a size of 700-800 μm into a mold with an inner diameter of 50 mm and a height of 50 mm, put the mold into a vacuum heat treatment furnace and sinter at a constant temperature of 700 ° C for 12 hours, Cooling with the furnace to obtain the open-pore porous sodium chloride preform; pour the Mg-3wt.%Nd-0.2wt.%Zn-0.5wt.%Zr alloy melt into the mold cavity with the open-pore porous sodium chloride preform , under the pressure of 2MPa, the pressure seepage casting is carried out; the outer skin of the sodium chloride-magnesium alloy composite structure is removed by a lathe, and the open-pore porous magnesium alloy can be obtained by washing with tap water for 1 hour, which is further processed into a pot-shaped porous magnesium alloy by mechanical processing.

[0055] Example steps of calcium phosphorus coating on the surface of porous magnes...

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Abstract

The invention relates to the technical field of tissue engineering articular cartilage repair, and in particular relates to a composite scaffold for hip articular cartilage repair and a preparation method of the composite scaffold. The scaffold is provided with a porous magnesium scaffold layer wrapped by bioceramics and a polymer hydrogel layer from the bottom to the top in sequence, the hydrogellayer is loaded with chondrocytes, and a three-layer structure including a subchondral bone layer and a calcification interface layer and a cartilage layer is formed after chondrocytes are implantedin a body. After the composite scaffold provided by the invention encounters a body fluid in the microenvironment of in-vivo tissue, the porous magnesium component in the scaffold is oxidized to generate hydrogen, the generated gas cannot be immediately diffused due to the limitation of a surface ceramic membrane, a gas film is formed locally, a stable isolation layer is formed, and an osteogenicmicroenvironment is isolated from a cartilage microenvironment, so that cells and cytokines in the osteogenic microenvironment below the cartilage microenvironment are prevented from entering the cartilage microenvironment, cartilage ossification can be prevented, the stability of the cartilage microenvironment is effectively maintained, and the composite scaffold is suitable for large-area cartilage repair, wherein the diameter of the repaired area is greater than 1 cm.

Description

technical field [0001] The invention relates to the technical field of tissue engineering articular cartilage repair, in particular to a composite bracket for hip articular cartilage repair and a preparation method. Background technique [0002] In recent years, the incidence of articular cartilage damage caused by osteoarthritis and exercise has gradually increased. Because cartilage tissue has no blood supply and innervation, and the low metabolic activity of chondrocytes and high-density extracellular matrix restrict the migration of chondrocytes to the defect area, and the ability of self-repair after damage is limited, tissue engineering plays an important role in cartilage repair. Great application prospects. [0003] The ideal state of articular cartilage repair is that the damaged cartilage can continue to generate hyaline cartilage, the new tissue can fuse with the surrounding tissue, and can meet the biological and mechanical characteristics of articular cartilage...

Claims

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Application Information

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IPC IPC(8): A61F2/32
CPCA61F2/32
Inventor 赵德伟于炜婷程亮亮袁广银李军雷郑国爽
Owner 赵德伟
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