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High-bonding-strength coating based on ion slow release and shape retention design as well as preparation method and application of high-bonding-strength coating

A technology of bonding strength and shape retention, applied in the direction of coating, metal material coating process, prosthesis, etc., can solve the problems of research inconsistency, peeling, single coating function, etc., to solve the problem of weak bonding strength and promote angiogenesis , The effect of simple preparation process

Active Publication Date: 2022-07-01
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The main reasons are: (1) The bonding force between the coating and the substrate is weak, and it is easy to wear and peel off during the whole implantation process, resulting in the failure of the coating
More seriously, the debris and tiny particles produced by the peeling of the coating may cause aseptic loosening, thereby significantly shortening the life of the implant; (2) the coating has a single function, and the traditional biological principle of developing bone implants is to directly Stimulation of osteogenic differentiation of mesenchymal stem cells
The neglect of other types of cells (such as endothelial cells, immune cells, neuronal fibers, etc.) in the complex system of bone and its surrounding microenvironment has resulted in general inconsistencies between in vitro and in vivo studies, restricting the possibility of further clinical applications (3) Insufficient stability of the coating's own structure and chemical properties
For example, at present, many implants with surface topological configurations inevitably undergo physical / chemical reactions with the surrounding microenvironment after implantation, resulting in dissolution, degradation, configuration collapse, etc. regulation

Method used

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  • High-bonding-strength coating based on ion slow release and shape retention design as well as preparation method and application of high-bonding-strength coating
  • High-bonding-strength coating based on ion slow release and shape retention design as well as preparation method and application of high-bonding-strength coating
  • High-bonding-strength coating based on ion slow release and shape retention design as well as preparation method and application of high-bonding-strength coating

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preparation example Construction

[0035] A second aspect of the present application provides a method for preparing a high-bonding strength coating based on ion sustained-release and shape-preserving design, comprising the following steps:

[0036] 1) The surface of the base titanium sheet is subjected to acid etching treatment, and the preparation process is as follows: first, after the base titanium sheet is polished with 400-mesh and 1500-mesh sandpaper in turn, put into deionized water, acetone, anhydrous ethanol, and deionized water. Ultrasonic cleaning was performed for 15 minutes, and then dried at 60°C. Next, 10 ml of concentrated nitric acid: hydrofluoric acid: deionized water in a volume ratio of 1:1:8 was used as an acid etching solution to clean and dry the The base titanium sheets are placed one by one, and the acid etching time is 5 minutes, so that pits with a diameter of 10-15 microns are formed on the surface of the base titanium sheet; rinse the acid-etched base with a large amount of deionize...

Embodiment 1

[0047] After polishing the base titanium sheet with 400-mesh and 1500-mesh sandpaper in turn, put it in deionized water, acetone, absolute ethanol, and deionized water, ultrasonically cleaned for 15 minutes in turn, and then dried at 60 °C; Concentrated nitric acid: hydrofluoric acid: deionized aqueous solution with a volume ratio of 1:1:8 in milliliters was used as an acid etching solution, and the cleaned and dried substrate titanium sheets were placed one by one, and the etching time was 5 minutes; The acid-etched base titanium sheet was rinsed with ionized water, and then dried at 60°C. The base titanium sheet without acid etching and acid etching was placed in a hydrothermal reactor, and 1M NaOH solution was used as the primary hydrothermal solution to react at 100 ° C for 1.5 hours to obtain dense titanate crystal nucleus; next , take out the sample after the first hydrothermal treatment, rinse it with a large amount of deionized water, and dry it at 60 °C; finally, put ...

Embodiment 2

[0049] After polishing the base titanium sheet with 400-mesh and 1500-mesh sandpaper in turn, put it in deionized water, acetone, absolute ethanol, and deionized water, ultrasonically cleaned for 15 minutes in turn, and then dried at 60 °C; Concentrated nitric acid: hydrofluoric acid: deionized aqueous solution with a volume ratio of 1:1:8 in milliliters was used as an acid etching solution, and the cleaned and dried substrate titanium sheets were placed one by one, and the etching time was 5 minutes; The acid-etched base titanium sheet was rinsed with ionized water, and then dried at 60°C. The base titanium sheet without acid etching and acid etching was placed in a hydrothermal reactor, and 1M NaOH solution was used as the primary hydrothermal solution to react at 100 ° C for 1.5 hours to obtain dense titanate crystal nucleus; next , take out the sample after the first hydrothermal treatment, rinse it with a large amount of deionized water, and dry it at 60 °C; finally, put ...

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Abstract

The invention discloses a high-bonding-strength coating based on ion slow release and shape retention design and a preparation method and application thereof, and belongs to the field of titanium-based surface treatment technology and biomedical application, and the mechanical embedding force of the coating and a substrate is increased through acid etching treatment to achieve high bonding strength; meanwhile, according to the characteristics of the crystal structure of the titanate, on the premise that the configuration of the titanate is basically unchanged, through ion exchange doping and Co < 2 + > release, and in combination with the nanorod topological configuration of the bone-imitating matrix, triple functions of inducing phagocytosis of macrophages to remove bacteria, promoting angiogenesis and promoting osteogenic differentiation of mesenchymal stem cells can be realized. The coating is simple in preparation method and wide in raw material source, and has a certain application prospect.

Description

technical field [0001] The invention belongs to the field of titanium-based surface treatment technology and biomedical application, and particularly relates to a high-bonding strength coating based on ion sustained-release and shape-preserving design, and a preparation method and application thereof. Background technique [0002] Bone defects due to tumor resection, traumatic fractures, sterile necrosis, osteolysis, osteomyelitis, periodontitis, and spinal fusion, etc., usually require artificial implants for functional reconstruction. Pure titanium and its alloys, as traditional hard tissue and substitute materials, due to their insufficient antibacterial ability and biocompatibility, can easily cause a large number of bacteria to adhere to form bacterial membranes and a strong immune rejection response of the host in the early stage of implantation. Eventually, good osseointegration cannot be formed and the implantation fails, and even complications such as osteomyelitis ...

Claims

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Application Information

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IPC IPC(8): C23C26/00C23F1/26A61L27/06A61L27/30A61L27/50A61L27/54
CPCC23C26/00C23F1/26A61L27/06A61L27/306A61L27/50A61L27/54A61L2430/02A61L2400/12A61L2300/102A61L2300/606A61L2300/404A61L2300/412A61L2420/06A61L2420/08A61L2300/602
Inventor 憨勇蔡心眉
Owner XI AN JIAOTONG UNIV
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